Fig 1: Enrichment plot: HALLMARK_PEROXISOME
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_PEROXISOME |
| Enrichment Score (ES) | -0.4947518 |
| Normalized Enrichment Score (NES) | -1.0656366 |
| Nominal p-value | 0.33292535 |
| FDR q-value | 0.5752373 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CACNA1B | calcium voltage-gated channel subunit alpha1 B [Source:HGNC Symbol;Acc:HGNC:1389] | 108 | 4.409 | 0.0341 | No |
| 2 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 328 | 3.403 | 0.0568 | No |
| 3 | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:3433] | 465 | 3.117 | 0.0792 | No |
| 4 | SOD2 | superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180] | 635 | 2.763 | 0.0979 | No |
| 5 | NUDT19 | nudix hydrolase 19 [Source:HGNC Symbol;Acc:HGNC:32036] | 675 | 2.697 | 0.1195 | No |
| 6 | SLC25A19 | solute carrier family 25 member 19 [Source:HGNC Symbol;Acc:HGNC:14409] | 1221 | 1.933 | 0.1210 | No |
| 7 | ACSL4 | acyl-CoA synthetase long chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] | 1335 | 1.834 | 0.1333 | No |
| 8 | ABCB9 | ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50] | 1404 | 1.763 | 0.1463 | No |
| 9 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 1706 | 1.532 | 0.1510 | No |
| 10 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 1730 | 1.518 | 0.1631 | No |
| 11 | DHRS3 | dehydrogenase/reductase 3 [Source:HGNC Symbol;Acc:HGNC:17693] | 1786 | 1.484 | 0.1741 | No |
| 12 | TSPO | translocator protein [Source:HGNC Symbol;Acc:HGNC:1158] | 2280 | 1.286 | 0.1716 | No |
| 13 | MVP | major vault protein [Source:HGNC Symbol;Acc:HGNC:7531] | 2390 | 1.222 | 0.1789 | No |
| 14 | CNBP | CCHC-type zinc finger nucleic acid binding protein [Source:HGNC Symbol;Acc:HGNC:13164] | 2437 | 1.199 | 0.1877 | No |
| 15 | PRDX1 | peroxiredoxin 1 [Source:HGNC Symbol;Acc:HGNC:9352] | 2580 | 1.125 | 0.1933 | No |
| 16 | CDK7 | cyclin dependent kinase 7 [Source:HGNC Symbol;Acc:HGNC:1778] | 2595 | 1.115 | 0.2023 | No |
| 17 | CRABP2 | cellular retinoic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2339] | 2955 | 0.949 | 0.2006 | No |
| 18 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 3280 | 0.842 | 0.1989 | No |
| 19 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 4092 | 0.579 | 0.1818 | No |
| 20 | YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [Source:HGNC Symbol;Acc:HGNC:12853] | 4196 | 0.548 | 0.1836 | No |
| 21 | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3435] | 4611 | 0.438 | 0.1761 | No |
| 22 | PEX5 | peroxisomal biogenesis factor 5 [Source:HGNC Symbol;Acc:HGNC:9719] | 4658 | 0.426 | 0.1784 | No |
| 23 | PEX14 | peroxisomal biogenesis factor 14 [Source:HGNC Symbol;Acc:HGNC:8856] | 4677 | 0.419 | 0.1815 | No |
| 24 | ACOT8 | acyl-CoA thioesterase 8 [Source:HGNC Symbol;Acc:HGNC:15919] | 5051 | 0.324 | 0.1741 | No |
| 25 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 5121 | 0.307 | 0.1748 | No |
| 26 | FIS1 | fission, mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:21689] | 5252 | 0.277 | 0.1736 | No |
| 27 | BCL10 | BCL10 immune signaling adaptor [Source:HGNC Symbol;Acc:HGNC:989] | 5460 | 0.226 | 0.1699 | No |
| 28 | CLN8 | CLN8 transmembrane ER and ERGIC protein [Source:HGNC Symbol;Acc:HGNC:2079] | 5569 | 0.202 | 0.1687 | No |
| 29 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 5618 | 0.186 | 0.1690 | No |
| 30 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 6167 | 0.054 | 0.1546 | No |
| 31 | ACOX1 | acyl-CoA oxidase 1 [Source:HGNC Symbol;Acc:HGNC:119] | 6219 | 0.039 | 0.1536 | No |
| 32 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8026 | 0.000 | 0.1047 | No |
| 33 | EHHADH | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3247] | 8045 | 0.000 | 0.1043 | No |
| 34 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9702 | 0.000 | 0.0595 | No |
| 35 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 10997 | 0.000 | 0.0245 | No |
| 36 | ESR2 | estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468] | 12069 | 0.000 | -0.0045 | No |
| 37 | STS | steroid sulfatase [Source:HGNC Symbol;Acc:HGNC:11425] | 12479 | 0.000 | -0.0155 | No |
| 38 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12750 | 0.000 | -0.0228 | No |
| 39 | HSD11B2 | hydroxysteroid 11-beta dehydrogenase 2 [Source:HGNC Symbol;Acc:HGNC:5209] | 14491 | 0.000 | -0.0699 | No |
| 40 | CEL | carboxyl ester lipase [Source:HGNC Symbol;Acc:HGNC:1848] | 15762 | 0.000 | -0.1042 | No |
| 41 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15822 | 0.000 | -0.1058 | No |
| 42 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17829 | 0.000 | -0.1600 | No |
| 43 | SEMA3C | semaphorin 3C [Source:HGNC Symbol;Acc:HGNC:10725] | 17902 | 0.000 | -0.1620 | No |
| 44 | UGT2B17 | UDP glucuronosyltransferase family 2 member B17 [Source:HGNC Symbol;Acc:HGNC:12547] | 18235 | 0.000 | -0.1710 | No |
| 45 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 20866 | 0.000 | -0.2421 | No |
| 46 | CRABP1 | cellular retinoic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2338] | 21159 | 0.000 | -0.2500 | No |
| 47 | SCGB1A1 | secretoglobin family 1A member 1 [Source:HGNC Symbol;Acc:HGNC:12523] | 21355 | 0.000 | -0.2552 | No |
| 48 | HAO2 | hydroxyacid oxidase 2 [Source:HGNC Symbol;Acc:HGNC:4810] | 22054 | 0.000 | -0.2741 | No |
| 49 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 23003 | 0.000 | -0.2997 | No |
| 50 | FABP6 | fatty acid binding protein 6 [Source:HGNC Symbol;Acc:HGNC:3561] | 24240 | 0.000 | -0.3331 | No |
| 51 | ALB | albumin [Source:HGNC Symbol;Acc:HGNC:399] | 24667 | 0.000 | -0.3447 | No |
| 52 | ABCC8 | ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 28338 | 0.000 | -0.4439 | No |
| 53 | PEX2 | peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717] | 28509 | -0.039 | -0.4482 | No |
| 54 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 28523 | -0.043 | -0.4481 | No |
| 55 | PABPC1 | poly(A) binding protein cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:8554] | 28538 | -0.048 | -0.4481 | No |
| 56 | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [Source:HGNC Symbol;Acc:HGNC:11104] | 29049 | -0.188 | -0.4603 | No |
| 57 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 29455 | -0.288 | -0.4689 | No |
| 58 | CTBP1 | C-terminal binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2494] | 30113 | -0.349 | -0.4837 | No |
| 59 | ITGB1BP1 | integrin subunit beta 1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23927] | 30523 | -0.455 | -0.4909 | Yes |
| 60 | CTPS1 | CTP synthase 1 [Source:HGNC Symbol;Acc:HGNC:2519] | 30537 | -0.460 | -0.4874 | Yes |
| 61 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 30616 | -0.479 | -0.4855 | Yes |
| 62 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 30700 | -0.501 | -0.4836 | Yes |
| 63 | SIAH1 | siah E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:10857] | 30861 | -0.547 | -0.4833 | Yes |
| 64 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 31017 | -0.594 | -0.4825 | Yes |
| 65 | RDH11 | retinol dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:17964] | 31071 | -0.611 | -0.4788 | Yes |
| 66 | ABCB1 | ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40] | 31270 | -0.658 | -0.4786 | Yes |
| 67 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 31311 | -0.672 | -0.4741 | Yes |
| 68 | FDPS | farnesyl diphosphate synthase [Source:HGNC Symbol;Acc:HGNC:3631] | 31610 | -0.767 | -0.4757 | Yes |
| 69 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 31910 | -0.851 | -0.4766 | Yes |
| 70 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 31929 | -0.858 | -0.4699 | Yes |
| 71 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 32187 | -0.934 | -0.4690 | Yes |
| 72 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 32403 | -1.002 | -0.4664 | Yes |
| 73 | HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase [Source:HGNC Symbol;Acc:HGNC:5005] | 32465 | -1.022 | -0.4595 | Yes |
| 74 | IDE | insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381] | 32590 | -1.046 | -0.4540 | Yes |
| 75 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 32898 | -1.165 | -0.4526 | Yes |
| 76 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 32973 | -1.193 | -0.4445 | Yes |
| 77 | SLC25A4 | solute carrier family 25 member 4 [Source:HGNC Symbol;Acc:HGNC:10990] | 33036 | -1.217 | -0.4360 | Yes |
| 78 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 33330 | -1.305 | -0.4330 | Yes |
| 79 | SLC25A17 | solute carrier family 25 member 17 [Source:HGNC Symbol;Acc:HGNC:10987] | 33528 | -1.402 | -0.4265 | Yes |
| 80 | CADM1 | cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5951] | 33689 | -1.467 | -0.4185 | Yes |
| 81 | PEX11B | peroxisomal biogenesis factor 11 beta [Source:HGNC Symbol;Acc:HGNC:8853] | 33930 | -1.582 | -0.4117 | Yes |
| 82 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 33990 | -1.614 | -0.3998 | Yes |
| 83 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 34151 | -1.695 | -0.3899 | Yes |
| 84 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 34247 | -1.740 | -0.3778 | Yes |
| 85 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 34291 | -1.761 | -0.3642 | Yes |
| 86 | ECI2 | enoyl-CoA delta isomerase 2 [Source:HGNC Symbol;Acc:HGNC:14601] | 34527 | -1.908 | -0.3545 | Yes |
| 87 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 34541 | -1.916 | -0.3388 | Yes |
| 88 | DLG4 | discs large MAGUK scaffold protein 4 [Source:HGNC Symbol;Acc:HGNC:2903] | 34593 | -1.945 | -0.3238 | Yes |
| 89 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 34930 | -2.058 | -0.3156 | Yes |
| 90 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35009 | -2.109 | -0.3000 | Yes |
| 91 | ACAA1 | acetyl-CoA acyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:82] | 35239 | -2.263 | -0.2872 | Yes |
| 92 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 35460 | -2.410 | -0.2730 | Yes |
| 93 | ABCC5 | ATP binding cassette subfamily C member 5 [Source:HGNC Symbol;Acc:HGNC:56] | 35479 | -2.422 | -0.2531 | Yes |
| 94 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 35557 | -2.490 | -0.2343 | Yes |
| 95 | ELOVL5 | ELOVL fatty acid elongase 5 [Source:HGNC Symbol;Acc:HGNC:21308] | 35682 | -2.599 | -0.2158 | Yes |
| 96 | ABCB4 | ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45] | 35709 | -2.616 | -0.1945 | Yes |
| 97 | ECH1 | enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149] | 35741 | -2.646 | -0.1732 | Yes |
| 98 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 35761 | -2.661 | -0.1513 | Yes |
| 99 | CLN6 | CLN6 transmembrane ER protein [Source:HGNC Symbol;Acc:HGNC:2077] | 36017 | -2.891 | -0.1340 | Yes |
| 100 | CRAT | carnitine O-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:2342] | 36090 | -2.978 | -0.1109 | Yes |
| 101 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36496 | -3.487 | -0.0926 | Yes |
| 102 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36786 | -3.986 | -0.0669 | Yes |
| 103 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 36883 | -4.190 | -0.0343 | Yes |
| 104 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37040 | -4.753 | 0.0014 | Yes |
