Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | 0.3931994 |
| Normalized Enrichment Score (NES) | 0.9927793 |
| Nominal p-value | 0.43434343 |
| FDR q-value | 0.4751598 |
| FWER p-Value | 0.979 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 362 | 3.299 | 0.0202 | Yes |
| 2 | MAP2K3 | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] | 558 | 2.886 | 0.0412 | Yes |
| 3 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 676 | 2.697 | 0.0625 | Yes |
| 4 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 696 | 2.644 | 0.0861 | Yes |
| 5 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 756 | 2.543 | 0.1076 | Yes |
| 6 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 780 | 2.501 | 0.1297 | Yes |
| 7 | TIAM1 | TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805] | 891 | 2.292 | 0.1476 | Yes |
| 8 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1024 | 2.169 | 0.1637 | Yes |
| 9 | ADCY2 | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] | 1211 | 1.938 | 0.1763 | Yes |
| 10 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 1220 | 1.934 | 0.1937 | Yes |
| 11 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 1464 | 1.710 | 0.2027 | Yes |
| 12 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 1520 | 1.670 | 0.2164 | Yes |
| 13 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 1551 | 1.650 | 0.2306 | Yes |
| 14 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] | 1640 | 1.579 | 0.2426 | Yes |
| 15 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1689 | 1.542 | 0.2553 | Yes |
| 16 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 1898 | 1.427 | 0.2626 | Yes |
| 17 | PRKCB | protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] | 2138 | 1.376 | 0.2687 | Yes |
| 18 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2413 | 1.208 | 0.2723 | Yes |
| 19 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 2470 | 1.185 | 0.2815 | Yes |
| 20 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] | 2537 | 1.145 | 0.2901 | Yes |
| 21 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303] | 2641 | 1.094 | 0.2973 | Yes |
| 22 | RPTOR | regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] | 2657 | 1.086 | 0.3068 | Yes |
| 23 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 2812 | 1.018 | 0.3119 | Yes |
| 24 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2946 | 0.955 | 0.3170 | Yes |
| 25 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 3033 | 0.929 | 0.3231 | Yes |
| 26 | FGF17 | fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673] | 3034 | 0.928 | 0.3315 | Yes |
| 27 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 3047 | 0.922 | 0.3396 | Yes |
| 28 | PPP1CA | protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281] | 3276 | 0.844 | 0.3411 | Yes |
| 29 | RIT1 | Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023] | 3288 | 0.840 | 0.3484 | Yes |
| 30 | PAK4 | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | 3351 | 0.818 | 0.3542 | Yes |
| 31 | ARHGDIA | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] | 3381 | 0.809 | 0.3608 | Yes |
| 32 | DDIT3 | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | 3382 | 0.809 | 0.3681 | Yes |
| 33 | YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] | 3491 | 0.772 | 0.3722 | Yes |
| 34 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 3827 | 0.668 | 0.3692 | Yes |
| 35 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 3984 | 0.613 | 0.3706 | Yes |
| 36 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 4019 | 0.602 | 0.3751 | Yes |
| 37 | ARPC3 | actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706] | 4072 | 0.585 | 0.3791 | Yes |
| 38 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 4276 | 0.524 | 0.3783 | Yes |
| 39 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 4353 | 0.509 | 0.3809 | Yes |
| 40 | SLA | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] | 4385 | 0.499 | 0.3846 | Yes |
| 41 | CAB39 | calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292] | 4387 | 0.498 | 0.3891 | Yes |
| 42 | CSNK2B | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] | 4425 | 0.490 | 0.3926 | Yes |
| 43 | ATF1 | activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] | 4555 | 0.454 | 0.3932 | Yes |
| 44 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 5176 | 0.291 | 0.3791 | No |
| 45 | GSK3B | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] | 5178 | 0.291 | 0.3817 | No |
| 46 | RALB | RAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840] | 5595 | 0.194 | 0.3722 | No |
| 47 | SMAD2 | SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] | 5615 | 0.187 | 0.3734 | No |
| 48 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 5768 | 0.148 | 0.3706 | No |
| 49 | AKT1 | AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] | 5863 | 0.130 | 0.3693 | No |
| 50 | MKNK1 | MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110] | 5991 | 0.100 | 0.3668 | No |
| 51 | AKT1S1 | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] | 6022 | 0.092 | 0.3668 | No |
| 52 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 6167 | 0.054 | 0.3634 | No |
| 53 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385] | 6238 | 0.034 | 0.3618 | No |
| 54 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377] | 6840 | 0.000 | 0.3456 | No |
| 55 | FGF22 | fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679] | 6960 | 0.000 | 0.3424 | No |
| 56 | PITX2 | paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] | 7418 | 0.000 | 0.3300 | No |
| 57 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 9187 | 0.000 | 0.2822 | No |
| 58 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 12666 | 0.000 | 0.1882 | No |
| 59 | GNGT1 | G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411] | 16281 | 0.000 | 0.0904 | No |
| 60 | IL4 | interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] | 17755 | 0.000 | 0.0506 | No |
| 61 | NGF | nerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808] | 19357 | 0.000 | 0.0073 | No |
| 62 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 20327 | 0.000 | -0.0189 | No |
| 63 | FGF6 | fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684] | 22718 | 0.000 | -0.0835 | No |
| 64 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 23405 | 0.000 | -0.1020 | No |
| 65 | GNA14 | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] | 24174 | 0.000 | -0.1228 | No |
| 66 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 25009 | 0.000 | -0.1453 | No |
| 67 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 27144 | 0.000 | -0.2030 | No |
| 68 | THEM4 | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] | 27892 | 0.000 | -0.2232 | No |
| 69 | ECSIT | ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548] | 28477 | -0.030 | -0.2388 | No |
| 70 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 28618 | -0.069 | -0.2419 | No |
| 71 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28769 | -0.115 | -0.2449 | No |
| 72 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 28826 | -0.131 | -0.2453 | No |
| 73 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 28843 | -0.135 | -0.2445 | No |
| 74 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 29067 | -0.195 | -0.2487 | No |
| 75 | TSC2 | TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] | 29447 | -0.284 | -0.2564 | No |
| 76 | RPS6KA1 | ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430] | 30193 | -0.371 | -0.2731 | No |
| 77 | CAB39L | calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] | 30361 | -0.408 | -0.2740 | No |
| 78 | MAPKAP1 | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] | 30485 | -0.442 | -0.2733 | No |
| 79 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 30618 | -0.479 | -0.2725 | No |
| 80 | GRK2 | G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289] | 30804 | -0.527 | -0.2727 | No |
| 81 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 30857 | -0.547 | -0.2691 | No |
| 82 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 31058 | -0.606 | -0.2690 | No |
| 83 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 31076 | -0.612 | -0.2639 | No |
| 84 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 31219 | -0.647 | -0.2619 | No |
| 85 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 31593 | -0.763 | -0.2650 | No |
| 86 | PTEN | phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] | 32059 | -0.894 | -0.2694 | No |
| 87 | ACACA | acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] | 32278 | -0.964 | -0.2666 | No |
| 88 | PIKFYVE | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] | 32531 | -1.027 | -0.2641 | No |
| 89 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 32564 | -1.037 | -0.2555 | No |
| 90 | DUSP3 | dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069] | 32633 | -1.065 | -0.2476 | No |
| 91 | SFN | stratifin [Source:HGNC Symbol;Acc:HGNC:10773] | 32913 | -1.169 | -0.2445 | No |
| 92 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181] | 33596 | -1.432 | -0.2500 | No |
| 93 | DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] | 33819 | -1.532 | -0.2420 | No |
| 94 | MKNK2 | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] | 34118 | -1.680 | -0.2348 | No |
| 95 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 34747 | -1.948 | -0.2341 | No |
| 96 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 34935 | -2.059 | -0.2204 | No |
| 97 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 34966 | -2.085 | -0.2023 | No |
| 98 | CXCR4 | C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] | 35680 | -2.596 | -0.1979 | No |
| 99 | VAV3 | vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659] | 35920 | -2.755 | -0.1794 | No |
| 100 | PLA2G12A | phospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554] | 36141 | -3.031 | -0.1577 | No |
| 101 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 36439 | -3.407 | -0.1348 | No |
| 102 | PLCG1 | phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065] | 36730 | -3.878 | -0.1074 | No |
| 103 | PDK1 | pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809] | 36816 | -4.038 | -0.0729 | No |
| 104 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 36828 | -4.064 | -0.0363 | No |
| 105 | MAP2K6 | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] | 37042 | -4.767 | 0.0013 | No |
