Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.49794558 |
| Normalized Enrichment Score (NES) | -1.0741715 |
| Nominal p-value | 0.3063291 |
| FDR q-value | 0.57928526 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 131 | 4.307 | 0.0464 | No |
| 2 | DST | dystonin [Source:HGNC Symbol;Acc:HGNC:1090] | 678 | 2.694 | 0.0629 | No |
| 3 | CTSC | cathepsin C [Source:HGNC Symbol;Acc:HGNC:2528] | 985 | 2.230 | 0.0805 | No |
| 4 | M6PR | mannose-6-phosphate receptor, cation dependent [Source:HGNC Symbol;Acc:HGNC:6752] | 1853 | 1.449 | 0.0739 | No |
| 5 | ATP6V1H | ATPase H+ transporting V1 subunit H [Source:HGNC Symbol;Acc:HGNC:18303] | 1886 | 1.433 | 0.0896 | No |
| 6 | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1 [Source:HGNC Symbol;Acc:HGNC:10831] | 2130 | 1.376 | 0.0990 | No |
| 7 | STX12 | syntaxin 12 [Source:HGNC Symbol;Acc:HGNC:11430] | 2203 | 1.338 | 0.1126 | No |
| 8 | YKT6 | YKT6 v-SNARE homolog [Source:HGNC Symbol;Acc:HGNC:16959] | 2688 | 1.071 | 0.1120 | No |
| 9 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 3033 | 0.929 | 0.1134 | No |
| 10 | TMX1 | thioredoxin related transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:15487] | 3064 | 0.917 | 0.1233 | No |
| 11 | AP2B1 | adaptor related protein complex 2 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:563] | 3447 | 0.784 | 0.1220 | No |
| 12 | ATP7A | ATPase copper transporting alpha [Source:HGNC Symbol;Acc:HGNC:869] | 3801 | 0.673 | 0.1203 | No |
| 13 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 4019 | 0.602 | 0.1214 | No |
| 14 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 4092 | 0.579 | 0.1262 | No |
| 15 | IGF2R | insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] | 4144 | 0.564 | 0.1314 | No |
| 16 | TPD52 | tumor protein D52 [Source:HGNC Symbol;Acc:HGNC:12005] | 4436 | 0.486 | 0.1291 | No |
| 17 | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] | 4460 | 0.481 | 0.1341 | No |
| 18 | OCRL | OCRL inositol polyphosphate-5-phosphatase [Source:HGNC Symbol;Acc:HGNC:8108] | 4679 | 0.418 | 0.1330 | No |
| 19 | SCAMP3 | secretory carrier membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:10565] | 4687 | 0.417 | 0.1377 | No |
| 20 | GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4181] | 4836 | 0.385 | 0.1382 | No |
| 21 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:799] | 5184 | 0.289 | 0.1321 | No |
| 22 | RAB2A | RAB2A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9763] | 5461 | 0.226 | 0.1273 | No |
| 23 | RER1 | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 5510 | 0.215 | 0.1285 | No |
| 24 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 5596 | 0.194 | 0.1284 | No |
| 25 | AP1G1 | adaptor related protein complex 1 subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:555] | 5660 | 0.174 | 0.1288 | No |
| 26 | ARFGEF1 | ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:15772] | 5670 | 0.172 | 0.1305 | No |
| 27 | RAB22A | RAB22A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9764] | 5695 | 0.168 | 0.1318 | No |
| 28 | ARCN1 | archain 1 [Source:HGNC Symbol;Acc:HGNC:649] | 5971 | 0.105 | 0.1256 | No |
| 29 | AP2S1 | adaptor related protein complex 2 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:565] | 5973 | 0.104 | 0.1268 | No |
| 30 | USO1 | USO1 vesicle transport factor [Source:HGNC Symbol;Acc:HGNC:30904] | 6040 | 0.088 | 0.1260 | No |
| 31 | TMED2 | transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] | 6071 | 0.077 | 0.1261 | No |
| 32 | CD63 | CD63 molecule [Source:HGNC Symbol;Acc:HGNC:1692] | 6192 | 0.047 | 0.1234 | No |
| 33 | TSPAN8 | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] | 11610 | 0.000 | -0.0230 | No |
| 34 | SCRN1 | secernin 1 [Source:HGNC Symbol;Acc:HGNC:22192] | 14176 | 0.000 | -0.0924 | No |
| 35 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 24505 | 0.000 | -0.3715 | No |
| 36 | KRT18 | keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430] | 26969 | 0.000 | -0.4381 | No |
| 37 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 27144 | 0.000 | -0.4428 | No |
| 38 | STAM | signal transducing adaptor molecule [Source:HGNC Symbol;Acc:HGNC:11357] | 28445 | -0.021 | -0.4777 | No |
| 39 | RAB14 | RAB14, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16524] | 28591 | -0.061 | -0.4809 | No |
| 40 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 28618 | -0.069 | -0.4808 | No |
| 41 | LMAN1 | lectin, mannose binding 1 [Source:HGNC Symbol;Acc:HGNC:6631] | 28685 | -0.088 | -0.4816 | No |
| 42 | BET1 | Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562] | 28883 | -0.144 | -0.4852 | No |
| 43 | NAPA | NSF attachment protein alpha [Source:HGNC Symbol;Acc:HGNC:7641] | 28897 | -0.148 | -0.4839 | No |
| 44 | ANP32E | acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol;Acc:HGNC:16673] | 28920 | -0.154 | -0.4827 | No |
| 45 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 29309 | -0.245 | -0.4903 | No |
| 46 | VAMP7 | vesicle associated membrane protein 7 [Source:HGNC Symbol;Acc:HGNC:11486] | 29450 | -0.285 | -0.4908 | No |
| 47 | TSG101 | tumor susceptibility 101 [Source:HGNC Symbol;Acc:HGNC:15971] | 29578 | -0.316 | -0.4906 | No |
| 48 | SEC24D | SEC24 homolog D, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10706] | 29596 | -0.319 | -0.4873 | No |
| 49 | RAB5A | RAB5A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9783] | 29990 | -0.321 | -0.4942 | Yes |
| 50 | STX16 | syntaxin 16 [Source:HGNC Symbol;Acc:HGNC:11431] | 29999 | -0.322 | -0.4907 | Yes |
| 51 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30116 | -0.350 | -0.4898 | Yes |
| 52 | TMED10 | transmembrane p24 trafficking protein 10 [Source:HGNC Symbol;Acc:HGNC:16998] | 30214 | -0.374 | -0.4881 | Yes |
| 53 | AP3S1 | adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013] | 30216 | -0.374 | -0.4837 | Yes |
| 54 | SNX2 | sorting nexin 2 [Source:HGNC Symbol;Acc:HGNC:11173] | 30229 | -0.378 | -0.4797 | Yes |
| 55 | COPB2 | COPI coat complex subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:2232] | 30324 | -0.399 | -0.4776 | Yes |
| 56 | KIF1B | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 30455 | -0.434 | -0.4761 | Yes |
| 57 | COPB1 | COPI coat complex subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:2231] | 30610 | -0.477 | -0.4747 | Yes |
| 58 | ERGIC3 | ERGIC and golgi 3 [Source:HGNC Symbol;Acc:HGNC:15927] | 30848 | -0.544 | -0.4748 | Yes |
| 59 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 31017 | -0.594 | -0.4725 | Yes |
| 60 | DOP1A | DOP1 leucine zipper like protein A [Source:HGNC Symbol;Acc:HGNC:21194] | 31031 | -0.597 | -0.4659 | Yes |
| 61 | CLTA | clathrin light chain A [Source:HGNC Symbol;Acc:HGNC:2090] | 31199 | -0.641 | -0.4629 | Yes |
| 62 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 31219 | -0.647 | -0.4560 | Yes |
| 63 | CLN5 | CLN5 intracellular trafficking protein [Source:HGNC Symbol;Acc:HGNC:2076] | 31260 | -0.656 | -0.4494 | Yes |
| 64 | GNAS | GNAS complex locus [Source:HGNC Symbol;Acc:HGNC:4392] | 31262 | -0.656 | -0.4418 | Yes |
| 65 | YIPF6 | Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304] | 31314 | -0.674 | -0.4354 | Yes |
| 66 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 31383 | -0.698 | -0.4291 | Yes |
| 67 | COG2 | component of oligomeric golgi complex 2 [Source:HGNC Symbol;Acc:HGNC:6546] | 31549 | -0.750 | -0.4249 | Yes |
| 68 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 31593 | -0.763 | -0.4172 | Yes |
| 69 | ZW10 | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] | 31728 | -0.801 | -0.4115 | Yes |
| 70 | ARFIP1 | ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] | 32204 | -0.939 | -0.4135 | Yes |
| 71 | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:15853] | 32208 | -0.940 | -0.4027 | Yes |
| 72 | SNAP23 | synaptosome associated protein 23 [Source:HGNC Symbol;Acc:HGNC:11131] | 32356 | -0.987 | -0.3952 | Yes |
| 73 | STX7 | syntaxin 7 [Source:HGNC Symbol;Acc:HGNC:11442] | 32393 | -0.999 | -0.3846 | Yes |
| 74 | NAPG | NSF attachment protein gamma [Source:HGNC Symbol;Acc:HGNC:7642] | 32439 | -1.016 | -0.3740 | Yes |
| 75 | AP3B1 | adaptor related protein complex 3 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:566] | 32533 | -1.028 | -0.3646 | Yes |
| 76 | GOLGA4 | golgin A4 [Source:HGNC Symbol;Acc:HGNC:4427] | 32720 | -1.101 | -0.3569 | Yes |
| 77 | SGMS1 | sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] | 32733 | -1.106 | -0.3444 | Yes |
| 78 | VPS45 | vacuolar protein sorting 45 homolog [Source:HGNC Symbol;Acc:HGNC:14579] | 32821 | -1.141 | -0.3335 | Yes |
| 79 | ARFGAP3 | ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:661] | 32927 | -1.174 | -0.3227 | Yes |
| 80 | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol;Acc:HGNC:29177] | 32984 | -1.197 | -0.3103 | Yes |
| 81 | PAM | peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol;Acc:HGNC:8596] | 33079 | -1.235 | -0.2985 | Yes |
| 82 | COPE | COPI coat complex subunit epsilon [Source:HGNC Symbol;Acc:HGNC:2234] | 33327 | -1.304 | -0.2901 | Yes |
| 83 | CLCN3 | chloride voltage-gated channel 3 [Source:HGNC Symbol;Acc:HGNC:2021] | 33594 | -1.431 | -0.2807 | Yes |
| 84 | DNM1L | dynamin 1 like [Source:HGNC Symbol;Acc:HGNC:2973] | 33629 | -1.445 | -0.2648 | Yes |
| 85 | ADAM10 | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] | 33831 | -1.536 | -0.2524 | Yes |
| 86 | ATP6V1B1 | ATPase H+ transporting V1 subunit B1 [Source:HGNC Symbol;Acc:HGNC:853] | 34214 | -1.722 | -0.2428 | Yes |
| 87 | SCAMP1 | secretory carrier membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:10563] | 34986 | -2.094 | -0.2393 | Yes |
| 88 | RAB9A | RAB9A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9792] | 34990 | -2.096 | -0.2151 | Yes |
| 89 | VAMP4 | vesicle associated membrane protein 4 [Source:HGNC Symbol;Acc:HGNC:12645] | 35027 | -2.117 | -0.1915 | Yes |
| 90 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35077 | -2.152 | -0.1679 | Yes |
| 91 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 35494 | -2.440 | -0.1508 | Yes |
| 92 | VAMP3 | vesicle associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 35603 | -2.528 | -0.1244 | Yes |
| 93 | TOM1L1 | target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] | 35904 | -2.735 | -0.1008 | Yes |
| 94 | ICA1 | islet cell autoantigen 1 [Source:HGNC Symbol;Acc:HGNC:5343] | 36101 | -2.991 | -0.0714 | Yes |
| 95 | BNIP3 | BCL2 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1084] | 36886 | -4.191 | -0.0439 | Yes |
| 96 | CAV2 | caveolin 2 [Source:HGNC Symbol;Acc:HGNC:1528] | 36914 | -4.260 | 0.0048 | Yes |
