Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.52246326 |
| Normalized Enrichment Score (NES) | 1.3260236 |
| Nominal p-value | 0.028735632 |
| FDR q-value | 0.07980111 |
| FWER p-Value | 0.196 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 119 | 4.357 | 0.0381 | Yes |
| 2 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 682 | 2.684 | 0.0484 | Yes |
| 3 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 770 | 2.525 | 0.0699 | Yes |
| 4 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 776 | 2.508 | 0.0936 | Yes |
| 5 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 977 | 2.236 | 0.1094 | Yes |
| 6 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 1021 | 2.176 | 0.1289 | Yes |
| 7 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 1034 | 2.153 | 0.1489 | Yes |
| 8 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 1039 | 2.146 | 0.1692 | Yes |
| 9 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 1137 | 2.017 | 0.1857 | Yes |
| 10 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1139 | 2.016 | 0.2048 | Yes |
| 11 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 1257 | 1.895 | 0.2196 | Yes |
| 12 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 1324 | 1.850 | 0.2353 | Yes |
| 13 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 1420 | 1.741 | 0.2493 | Yes |
| 14 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 1480 | 1.695 | 0.2638 | Yes |
| 15 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 1569 | 1.639 | 0.2769 | Yes |
| 16 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 1574 | 1.634 | 0.2923 | Yes |
| 17 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 1695 | 1.540 | 0.3037 | Yes |
| 18 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 1878 | 1.438 | 0.3124 | Yes |
| 19 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 1911 | 1.419 | 0.3250 | Yes |
| 20 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 2239 | 1.319 | 0.3286 | Yes |
| 21 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 2244 | 1.314 | 0.3410 | Yes |
| 22 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 2263 | 1.302 | 0.3529 | Yes |
| 23 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 2296 | 1.276 | 0.3641 | Yes |
| 24 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 2371 | 1.230 | 0.3738 | Yes |
| 25 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 2388 | 1.222 | 0.3849 | Yes |
| 26 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2413 | 1.208 | 0.3957 | Yes |
| 27 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 2474 | 1.182 | 0.4053 | Yes |
| 28 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 2585 | 1.122 | 0.4130 | Yes |
| 29 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 2680 | 1.075 | 0.4206 | Yes |
| 30 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 2700 | 1.063 | 0.4302 | Yes |
| 31 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 2845 | 1.006 | 0.4358 | Yes |
| 32 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 2847 | 1.004 | 0.4453 | Yes |
| 33 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 3042 | 0.925 | 0.4489 | Yes |
| 34 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 3167 | 0.881 | 0.4539 | Yes |
| 35 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 3231 | 0.857 | 0.4603 | Yes |
| 36 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 3363 | 0.815 | 0.4645 | Yes |
| 37 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 3434 | 0.789 | 0.4701 | Yes |
| 38 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 3510 | 0.765 | 0.4753 | Yes |
| 39 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 3522 | 0.758 | 0.4822 | Yes |
| 40 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 3536 | 0.754 | 0.4890 | Yes |
| 41 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 3597 | 0.731 | 0.4943 | Yes |
| 42 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 3712 | 0.689 | 0.4977 | Yes |
| 43 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 3804 | 0.673 | 0.5017 | Yes |
| 44 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 3976 | 0.616 | 0.5029 | Yes |
| 45 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 4236 | 0.535 | 0.5009 | Yes |
| 46 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 4352 | 0.510 | 0.5027 | Yes |
| 47 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 4587 | 0.444 | 0.5005 | Yes |
| 48 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 4644 | 0.430 | 0.5031 | Yes |
| 49 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 4646 | 0.430 | 0.5072 | Yes |
| 50 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 4700 | 0.415 | 0.5097 | Yes |
| 51 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 4745 | 0.404 | 0.5123 | Yes |
| 52 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 4820 | 0.389 | 0.5140 | Yes |
| 53 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 4963 | 0.351 | 0.5135 | Yes |
| 54 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 5060 | 0.321 | 0.5139 | Yes |
| 55 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 5069 | 0.318 | 0.5167 | Yes |
| 56 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 5072 | 0.317 | 0.5197 | Yes |
| 57 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 5231 | 0.280 | 0.5181 | Yes |
| 58 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 5234 | 0.280 | 0.5207 | Yes |
| 59 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 5465 | 0.225 | 0.5166 | Yes |
| 60 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 5468 | 0.225 | 0.5187 | Yes |
| 61 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 5527 | 0.212 | 0.5191 | Yes |
| 62 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 5596 | 0.194 | 0.5191 | Yes |
| 63 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 5605 | 0.189 | 0.5207 | Yes |
| 64 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 5612 | 0.188 | 0.5223 | Yes |
| 65 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 5746 | 0.154 | 0.5202 | Yes |
| 66 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 5759 | 0.149 | 0.5212 | Yes |
| 67 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 5767 | 0.149 | 0.5225 | Yes |
| 68 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 6032 | 0.090 | 0.5162 | No |
| 69 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 6060 | 0.081 | 0.5162 | No |
| 70 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 6148 | 0.060 | 0.5144 | No |
| 71 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 6366 | 0.003 | 0.5086 | No |
| 72 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11878 | 0.000 | 0.3596 | No |
| 73 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 18583 | 0.000 | 0.1783 | No |
| 74 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 27961 | 0.000 | -0.0753 | No |
| 75 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 28454 | -0.024 | -0.0884 | No |
| 76 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 28512 | -0.040 | -0.0896 | No |
| 77 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 28623 | -0.071 | -0.0919 | No |
| 78 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28640 | -0.077 | -0.0916 | No |
| 79 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 28671 | -0.083 | -0.0916 | No |
| 80 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 28815 | -0.125 | -0.0943 | No |
| 81 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 28863 | -0.139 | -0.0942 | No |
| 82 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 29019 | -0.181 | -0.0967 | No |
| 83 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 29067 | -0.195 | -0.0961 | No |
| 84 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 29080 | -0.198 | -0.0946 | No |
| 85 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 29189 | -0.218 | -0.0954 | No |
| 86 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 29207 | -0.222 | -0.0938 | No |
| 87 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 29210 | -0.222 | -0.0917 | No |
| 88 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 29309 | -0.245 | -0.0921 | No |
| 89 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 29520 | -0.304 | -0.0949 | No |
| 90 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 30045 | -0.333 | -0.1059 | No |
| 91 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 30232 | -0.378 | -0.1073 | No |
| 92 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 30291 | -0.390 | -0.1052 | No |
| 93 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 30347 | -0.404 | -0.1028 | No |
| 94 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 30352 | -0.405 | -0.0991 | No |
| 95 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 30618 | -0.479 | -0.1017 | No |
| 96 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 30716 | -0.505 | -0.0996 | No |
| 97 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 31607 | -0.767 | -0.1164 | No |
| 98 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 31896 | -0.847 | -0.1161 | No |
| 99 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 31998 | -0.873 | -0.1106 | No |
| 100 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 32247 | -0.953 | -0.1082 | No |
| 101 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 32618 | -1.060 | -0.1082 | No |
| 102 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 32627 | -1.064 | -0.0983 | No |
| 103 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 32728 | -1.104 | -0.0906 | No |
| 104 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 32812 | -1.136 | -0.0820 | No |
| 105 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 33458 | -1.369 | -0.0865 | No |
| 106 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 33961 | -1.598 | -0.0849 | No |
| 107 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 34115 | -1.678 | -0.0731 | No |
| 108 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 34121 | -1.681 | -0.0573 | No |
| 109 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 35298 | -2.302 | -0.0673 | No |
| 110 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 35325 | -2.321 | -0.0460 | No |
| 111 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 35649 | -2.572 | -0.0303 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 35972 | -2.829 | -0.0122 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 36977 | -4.475 | 0.0031 | No |
