Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.8703367 |
| Normalized Enrichment Score (NES) | 2.155417 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 19 | 4.971 | 0.0392 | Yes |
| 2 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 36 | 4.945 | 0.0783 | Yes |
| 3 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 51 | 4.875 | 0.1168 | Yes |
| 4 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 53 | 4.874 | 0.1557 | Yes |
| 5 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 54 | 4.870 | 0.1946 | Yes |
| 6 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 63 | 4.848 | 0.2331 | Yes |
| 7 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 73 | 4.798 | 0.2712 | Yes |
| 8 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 96 | 4.689 | 0.3080 | Yes |
| 9 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 105 | 4.608 | 0.3446 | Yes |
| 10 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 106 | 4.607 | 0.3814 | Yes |
| 11 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 123 | 4.514 | 0.4170 | Yes |
| 12 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 217 | 4.103 | 0.4473 | Yes |
| 13 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 252 | 3.978 | 0.4781 | Yes |
| 14 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 301 | 3.811 | 0.5073 | Yes |
| 15 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 308 | 3.777 | 0.5373 | Yes |
| 16 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 310 | 3.764 | 0.5673 | Yes |
| 17 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 484 | 3.259 | 0.5887 | Yes |
| 18 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 497 | 3.222 | 0.6141 | Yes |
| 19 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 579 | 3.054 | 0.6363 | Yes |
| 20 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 635 | 2.926 | 0.6582 | Yes |
| 21 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 690 | 2.816 | 0.6792 | Yes |
| 22 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 830 | 2.613 | 0.6963 | Yes |
| 23 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 977 | 2.389 | 0.7115 | Yes |
| 24 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 1008 | 2.327 | 0.7292 | Yes |
| 25 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1030 | 2.281 | 0.7469 | Yes |
| 26 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1076 | 2.229 | 0.7635 | Yes |
| 27 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 1142 | 2.136 | 0.7788 | Yes |
| 28 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1236 | 2.021 | 0.7924 | Yes |
| 29 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1338 | 1.913 | 0.8049 | Yes |
| 30 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 1587 | 1.775 | 0.8124 | Yes |
| 31 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 1782 | 1.584 | 0.8198 | Yes |
| 32 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 1809 | 1.567 | 0.8316 | Yes |
| 33 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 2181 | 1.308 | 0.8321 | Yes |
| 34 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 2241 | 1.274 | 0.8406 | Yes |
| 35 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 2347 | 1.205 | 0.8474 | Yes |
| 36 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 2405 | 1.174 | 0.8553 | Yes |
| 37 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2591 | 1.095 | 0.8590 | Yes |
| 38 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 2630 | 1.073 | 0.8665 | Yes |
| 39 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 2884 | 0.952 | 0.8673 | Yes |
| 40 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 3061 | 0.866 | 0.8695 | Yes |
| 41 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 3266 | 0.797 | 0.8703 | Yes |
| 42 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 3718 | 0.628 | 0.8632 | No |
| 43 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 4920 | 0.255 | 0.8328 | No |
| 44 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 5246 | 0.159 | 0.8252 | No |
| 45 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 5454 | 0.153 | 0.8209 | No |
| 46 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12349 | 0.000 | 0.6346 | No |
| 47 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18156 | 0.000 | 0.4778 | No |
| 48 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18157 | 0.000 | 0.4778 | No |
| 49 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18159 | 0.000 | 0.4778 | No |
| 50 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18161 | 0.000 | 0.4778 | No |
| 51 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18168 | 0.000 | 0.4776 | No |
| 52 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18176 | 0.000 | 0.4774 | No |
| 53 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18446 | 0.000 | 0.4701 | No |
| 54 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18455 | 0.000 | 0.4699 | No |
| 55 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 20260 | 0.000 | 0.4212 | No |
| 56 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 21754 | 0.000 | 0.3809 | No |
| 57 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 21755 | 0.000 | 0.3809 | No |
| 58 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 21757 | 0.000 | 0.3808 | No |
| 59 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 21759 | 0.000 | 0.3808 | No |
| 60 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 21760 | 0.000 | 0.3808 | No |
| 61 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 21761 | 0.000 | 0.3808 | No |
| 62 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 21763 | 0.000 | 0.3808 | No |
| 63 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21793 | 0.000 | 0.3800 | No |
| 64 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24519 | 0.000 | 0.3064 | No |
| 65 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 25400 | 0.000 | 0.2826 | No |
| 66 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 28545 | -0.108 | 0.1985 | No |
| 67 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 28816 | -0.182 | 0.1927 | No |
| 68 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 29057 | -0.248 | 0.1882 | No |
| 69 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 29070 | -0.251 | 0.1899 | No |
| 70 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 29526 | -0.370 | 0.1805 | No |
| 71 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 30853 | -0.696 | 0.1503 | No |
| 72 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 32214 | -1.134 | 0.1226 | No |
| 73 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 32231 | -1.140 | 0.1313 | No |
