Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | SANA_TNF_SIGNALING_UP |
| Enrichment Score (ES) | 0.81966454 |
| Normalized Enrichment Score (NES) | 2.0129726 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.566497E-4 |
| FWER p-Value | 0.002 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 36 | 4.945 | 0.0302 | Yes |
| 2 | GBP1 | guanylate binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4182] | 47 | 4.882 | 0.0606 | Yes |
| 3 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 51 | 4.875 | 0.0913 | Yes |
| 4 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 54 | 4.870 | 0.1219 | Yes |
| 5 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 59 | 4.856 | 0.1524 | Yes |
| 6 | SLC15A3 | solute carrier family 15 member 3 [Source:HGNC Symbol;Acc:HGNC:18068] | 90 | 4.724 | 0.1813 | Yes |
| 7 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 102 | 4.637 | 0.2102 | Yes |
| 8 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 117 | 4.553 | 0.2385 | Yes |
| 9 | LGALS9 | galectin 9 [Source:HGNC Symbol;Acc:HGNC:6570] | 124 | 4.510 | 0.2667 | Yes |
| 10 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 150 | 4.382 | 0.2937 | Yes |
| 11 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 182 | 4.222 | 0.3194 | Yes |
| 12 | PLA1A | phospholipase A1 member A [Source:HGNC Symbol;Acc:HGNC:17661] | 189 | 4.200 | 0.3457 | Yes |
| 13 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 227 | 4.065 | 0.3703 | Yes |
| 14 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 270 | 3.926 | 0.3939 | Yes |
| 15 | TNFAIP3 | TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] | 271 | 3.923 | 0.4186 | Yes |
| 16 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 301 | 3.811 | 0.4418 | Yes |
| 17 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 310 | 3.764 | 0.4653 | Yes |
| 18 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 320 | 3.719 | 0.4885 | Yes |
| 19 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 326 | 3.698 | 0.5116 | Yes |
| 20 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 330 | 3.672 | 0.5347 | Yes |
| 21 | LIPG | lipase G, endothelial type [Source:HGNC Symbol;Acc:HGNC:6623] | 353 | 3.618 | 0.5569 | Yes |
| 22 | ITGAV | integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] | 401 | 3.458 | 0.5774 | Yes |
| 23 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 435 | 3.396 | 0.5979 | Yes |
| 24 | TNIP1 | TNFAIP3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16903] | 444 | 3.352 | 0.6188 | Yes |
| 25 | SOD2 | superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180] | 460 | 3.318 | 0.6393 | Yes |
| 26 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 484 | 3.259 | 0.6592 | Yes |
| 27 | IL7R | interleukin 7 receptor [Source:HGNC Symbol;Acc:HGNC:6024] | 569 | 3.069 | 0.6762 | Yes |
| 28 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 579 | 3.054 | 0.6952 | Yes |
| 29 | INHBA | inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066] | 603 | 2.990 | 0.7134 | Yes |
| 30 | TNFAIP2 | TNF alpha induced protein 2 [Source:HGNC Symbol;Acc:HGNC:11895] | 763 | 2.669 | 0.7259 | Yes |
| 31 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 778 | 2.636 | 0.7422 | Yes |
| 32 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 1076 | 2.229 | 0.7482 | Yes |
| 33 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1313 | 1.940 | 0.7540 | Yes |
| 34 | DNAJA1 | DnaJ heat shock protein family (Hsp40) member A1 [Source:HGNC Symbol;Acc:HGNC:5229] | 1359 | 1.888 | 0.7647 | Yes |
| 35 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 1587 | 1.775 | 0.7697 | Yes |
| 36 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 1668 | 1.672 | 0.7781 | Yes |
| 37 | FTH1 | ferritin heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:3976] | 1772 | 1.593 | 0.7853 | Yes |
| 38 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 1782 | 1.584 | 0.7951 | Yes |
| 39 | SAT1 | spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540] | 1877 | 1.518 | 0.8021 | Yes |
| 40 | CASP1 | caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499] | 2025 | 1.407 | 0.8070 | Yes |
| 41 | BIRC3 | baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591] | 2131 | 1.335 | 0.8126 | Yes |
| 42 | RABL3 | RAB, member of RAS oncogene family like 3 [Source:HGNC Symbol;Acc:HGNC:18072] | 2175 | 1.313 | 0.8197 | Yes |
| 43 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2591 | 1.095 | 0.8153 | No |
| 44 | RAC3 | Rac family small GTPase 3 [Source:HGNC Symbol;Acc:HGNC:9803] | 3432 | 0.727 | 0.7972 | No |
| 45 | SPAG9 | sperm associated antigen 9 [Source:HGNC Symbol;Acc:HGNC:14524] | 4640 | 0.328 | 0.7667 | No |
| 46 | DENND11 | DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472] | 4743 | 0.302 | 0.7658 | No |
| 47 | CCL11 | C-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10610] | 6185 | 0.000 | 0.7269 | No |
| 48 | CCL20 | C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] | 6220 | 0.000 | 0.7260 | No |
| 49 | PDGFRL | platelet derived growth factor receptor like [Source:HGNC Symbol;Acc:HGNC:8805] | 7373 | 0.000 | 0.6948 | No |
| 50 | APOL1 | apolipoprotein L1 [Source:HGNC Symbol;Acc:HGNC:618] | 9961 | 0.000 | 0.6249 | No |
| 51 | APOL3 | apolipoprotein L3 [Source:HGNC Symbol;Acc:HGNC:14868] | 9963 | 0.000 | 0.6249 | No |
| 52 | CX3CL1 | C-X3-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10647] | 10643 | 0.000 | 0.6066 | No |
| 53 | ACKR3 | atypical chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:23692] | 11010 | 0.000 | 0.5967 | No |
| 54 | ICOSLG | inducible T cell costimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087] | 11123 | 0.000 | 0.5936 | No |
| 55 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12349 | 0.000 | 0.5605 | No |
| 56 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12679 | 0.000 | 0.5517 | No |
| 57 | IL32 | interleukin 32 [Source:HGNC Symbol;Acc:HGNC:16830] | 13723 | 0.000 | 0.5235 | No |
| 58 | VCAM1 | vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] | 13781 | 0.000 | 0.5219 | No |
| 59 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18237 | 0.000 | 0.4016 | No |
| 60 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18917 | 0.000 | 0.3832 | No |
| 61 | CTHRC1 | collagen triple helix repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:18831] | 18945 | 0.000 | 0.3825 | No |
| 62 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19117 | 0.000 | 0.3779 | No |
| 63 | CXCL6 | C-X-C motif chemokine ligand 6 [Source:HGNC Symbol;Acc:HGNC:10643] | 19463 | 0.000 | 0.3685 | No |
| 64 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19468 | 0.000 | 0.3684 | No |
| 65 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19479 | 0.000 | 0.3682 | No |
| 66 | CXCL2 | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] | 19480 | 0.000 | 0.3682 | No |
| 67 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 20701 | 0.000 | 0.3352 | No |
| 68 | LAMB3 | laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] | 20770 | 0.000 | 0.3333 | No |
| 69 | ANO9 | anoctamin 9 [Source:HGNC Symbol;Acc:HGNC:20679] | 22145 | 0.000 | 0.2962 | No |
| 70 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 24355 | 0.000 | 0.2365 | No |
| 71 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 25600 | 0.000 | 0.2029 | No |
| 72 | CCL8 | C-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:10635] | 27830 | 0.000 | 0.1427 | No |
| 73 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 27832 | 0.000 | 0.1427 | No |
| 74 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 27840 | 0.000 | 0.1425 | No |
| 75 | ATP13A3 | ATPase 13A3 [Source:HGNC Symbol;Acc:HGNC:24113] | 31404 | -0.860 | 0.0516 | No |
| 76 | C1QTNF1 | C1q and TNF related 1 [Source:HGNC Symbol;Acc:HGNC:14324] | 32611 | -1.291 | 0.0272 | No |
| 77 | RHOB | ras homolog family member B [Source:HGNC Symbol;Acc:HGNC:668] | 33398 | -1.552 | 0.0157 | No |
| 78 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 33542 | -1.617 | 0.0220 | No |
| 79 | DRAM1 | DNA damage regulated autophagy modulator 1 [Source:HGNC Symbol;Acc:HGNC:25645] | 33767 | -1.717 | 0.0268 | No |
| 80 | NCEH1 | neutral cholesterol ester hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:29260] | 34118 | -1.885 | 0.0292 | No |
| 81 | OXR1 | oxidation resistance 1 [Source:HGNC Symbol;Acc:HGNC:15822] | 34522 | -2.104 | 0.0315 | No |
| 82 | BPGM | bisphosphoglycerate mutase [Source:HGNC Symbol;Acc:HGNC:1093] | 35381 | -2.658 | 0.0251 | No |
| 83 | SMAD3 | SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] | 36143 | -3.343 | 0.0256 | No |
