Fig 1: Enrichment plot: IRF2_01
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | IRF2_01 |
| Enrichment Score (ES) | 0.49795446 |
| Normalized Enrichment Score (NES) | 1.3087944 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 15 | 4.981 | 0.0314 | Yes |
| 2 | IL27 | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 17 | 4.972 | 0.0631 | Yes |
| 3 | PGM5 | phosphoglucomutase 5 [Source:HGNC Symbol;Acc:HGNC:8908] | 95 | 4.692 | 0.0910 | Yes |
| 4 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 102 | 4.637 | 0.1204 | Yes |
| 5 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 106 | 4.607 | 0.1498 | Yes |
| 6 | OSM | oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] | 162 | 4.325 | 0.1759 | Yes |
| 7 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 213 | 4.127 | 0.2009 | Yes |
| 8 | SYNE2 | spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol;Acc:HGNC:17084] | 261 | 3.955 | 0.2249 | Yes |
| 9 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 371 | 3.546 | 0.2446 | Yes |
| 10 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 383 | 3.515 | 0.2667 | Yes |
| 11 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 435 | 3.396 | 0.2871 | Yes |
| 12 | NT5C3A | 5'-nucleotidase, cytosolic IIIA [Source:HGNC Symbol;Acc:HGNC:17820] | 507 | 3.190 | 0.3055 | Yes |
| 13 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 533 | 3.106 | 0.3247 | Yes |
| 14 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 597 | 2.997 | 0.3421 | Yes |
| 15 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 752 | 2.696 | 0.3551 | Yes |
| 16 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 846 | 2.601 | 0.3692 | Yes |
| 17 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 852 | 2.588 | 0.3856 | Yes |
| 18 | MED13 | mediator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:22474] | 853 | 2.587 | 0.4021 | Yes |
| 19 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 977 | 2.389 | 0.4141 | Yes |
| 20 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 1071 | 2.234 | 0.4258 | Yes |
| 21 | PIGV | phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol;Acc:HGNC:26031] | 1192 | 2.070 | 0.4358 | Yes |
| 22 | LRATD2 | LRAT domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24166] | 1228 | 2.026 | 0.4478 | Yes |
| 23 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] | 1345 | 1.906 | 0.4568 | Yes |
| 24 | TCIRG1 | T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol;Acc:HGNC:11647] | 1428 | 1.808 | 0.4661 | Yes |
| 25 | TMBIM4 | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] | 1572 | 1.787 | 0.4737 | Yes |
| 26 | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17017] | 2069 | 1.386 | 0.4691 | Yes |
| 27 | DNASE1L3 | deoxyribonuclease 1 like 3 [Source:HGNC Symbol;Acc:HGNC:2959] | 2076 | 1.380 | 0.4778 | Yes |
| 28 | IL11 | interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] | 2119 | 1.343 | 0.4852 | Yes |
| 29 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 2262 | 1.259 | 0.4894 | Yes |
| 30 | PCGF5 | polycomb group ring finger 5 [Source:HGNC Symbol;Acc:HGNC:28264] | 2356 | 1.200 | 0.4946 | Yes |
| 31 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] | 2791 | 0.989 | 0.4891 | Yes |
| 32 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 2897 | 0.945 | 0.4923 | Yes |
| 33 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 2911 | 0.938 | 0.4980 | Yes |
| 34 | SLC38A2 | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] | 3619 | 0.663 | 0.4831 | No |
| 35 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] | 3749 | 0.620 | 0.4835 | No |
| 36 | PRKD3 | protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] | 4050 | 0.519 | 0.4787 | No |
| 37 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 4320 | 0.421 | 0.4741 | No |
| 38 | CASZ1 | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] | 4385 | 0.398 | 0.4750 | No |
| 39 | UPF2 | UPF2 regulator of nonsense mediated mRNA decay [Source:HGNC Symbol;Acc:HGNC:17854] | 5013 | 0.225 | 0.4594 | No |
| 40 | DLX1 | distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] | 5311 | 0.153 | 0.4524 | No |
| 41 | DUSP10 | dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065] | 5658 | 0.151 | 0.4440 | No |
| 42 | TMEM229B | transmembrane protein 229B [Source:HGNC Symbol;Acc:HGNC:20130] | 5784 | 0.108 | 0.4413 | No |
| 43 | PRKD2 | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] | 5887 | 0.077 | 0.4390 | No |
| 44 | PRDM16 | PR/SET domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] | 6784 | 0.000 | 0.4148 | No |
| 45 | ASPA | aspartoacylase [Source:HGNC Symbol;Acc:HGNC:756] | 7636 | 0.000 | 0.3918 | No |
| 46 | BHLHE22 | basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] | 8072 | 0.000 | 0.3800 | No |
| 47 | PROX1 | prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] | 8266 | 0.000 | 0.3748 | No |
| 48 | HOXA6 | homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] | 8676 | 0.000 | 0.3637 | No |
| 49 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] | 9660 | 0.000 | 0.3371 | No |
| 50 | H4C7 | H4 clustered histone 7 [Source:HGNC Symbol;Acc:HGNC:4792] | 10082 | 0.000 | 0.3257 | No |
| 51 | RTL9 | retrotransposon Gag like 9 [Source:HGNC Symbol;Acc:HGNC:29245] | 10372 | 0.000 | 0.3179 | No |
| 52 | LDB2 | LIM domain binding 2 [Source:HGNC Symbol;Acc:HGNC:6533] | 10980 | 0.000 | 0.3015 | No |
| 53 | TMPRSS5 | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] | 11479 | 0.000 | 0.2880 | No |
| 54 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12349 | 0.000 | 0.2645 | No |
| 55 | MSX1 | msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] | 12386 | 0.000 | 0.2635 | No |
| 56 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12679 | 0.000 | 0.2556 | No |
| 57 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12819 | 0.000 | 0.2519 | No |
| 58 | TMEM108 | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] | 13390 | 0.000 | 0.2364 | No |
| 59 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13428 | 0.000 | 0.2354 | No |
| 60 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14076 | 0.000 | 0.2179 | No |
| 61 | FLT3LG | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] | 14090 | 0.000 | 0.2176 | No |
| 62 | RFX4 | regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] | 14312 | 0.000 | 0.2116 | No |
| 63 | BLK | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] | 15469 | 0.000 | 0.1803 | No |
| 64 | TGFB3 | transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] | 16596 | 0.000 | 0.1499 | No |
| 65 | DLX4 | distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] | 16711 | 0.000 | 0.1468 | No |
| 66 | IKZF2 | IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] | 18234 | 0.000 | 0.1056 | No |
| 67 | ME3 | malic enzyme 3 [Source:HGNC Symbol;Acc:HGNC:6985] | 18924 | 0.000 | 0.0870 | No |
| 68 | NDN | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] | 19278 | 0.000 | 0.0774 | No |
| 69 | BNC2 | basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] | 19285 | 0.000 | 0.0773 | No |
| 70 | OTX1 | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] | 19445 | 0.000 | 0.0730 | No |
| 71 | TBX1 | T-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11592] | 19742 | 0.000 | 0.0649 | No |
| 72 | NPR3 | natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] | 20720 | 0.000 | 0.0385 | No |
| 73 | EGFL6 | EGF like domain multiple 6 [Source:HGNC Symbol;Acc:HGNC:3235] | 21011 | 0.000 | 0.0307 | No |
| 74 | CCDC68 | coiled-coil domain containing 68 [Source:HGNC Symbol;Acc:HGNC:24350] | 21687 | 0.000 | 0.0124 | No |
| 75 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21793 | 0.000 | 0.0096 | No |
| 76 | IFNL2 | interferon lambda 2 [Source:HGNC Symbol;Acc:HGNC:18364] | 21894 | 0.000 | 0.0069 | No |
| 77 | IFNL3 | interferon lambda 3 [Source:HGNC Symbol;Acc:HGNC:18365] | 21905 | 0.000 | 0.0066 | No |
| 78 | KCNMB3 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6287] | 21952 | 0.000 | 0.0053 | No |
| 79 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24519 | 0.000 | -0.0641 | No |
| 80 | AGBL2 | ATP/GTP binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:26296] | 25264 | 0.000 | -0.0842 | No |
| 81 | BCL11A | BAF chromatin remodeling complex subunit BCL11A [Source:HGNC Symbol;Acc:HGNC:13221] | 25372 | 0.000 | -0.0871 | No |
| 82 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 27684 | 0.000 | -0.1496 | No |
| 83 | ASH1L | ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] | 28526 | -0.103 | -0.1717 | No |
| 84 | CAPRIN1 | cell cycle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:6743] | 28578 | -0.120 | -0.1723 | No |
| 85 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] | 28659 | -0.141 | -0.1736 | No |
| 86 | CUL2 | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] | 28665 | -0.143 | -0.1728 | No |
| 87 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28669 | -0.144 | -0.1720 | No |
| 88 | KARS1 | lysyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:6215] | 28745 | -0.166 | -0.1729 | No |
| 89 | TRPM3 | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] | 28752 | -0.168 | -0.1720 | No |
| 90 | DLG1 | discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900] | 28915 | -0.214 | -0.1750 | No |
| 91 | NABP2 | nucleic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28412] | 29052 | -0.246 | -0.1771 | No |
| 92 | HPCAL1 | hippocalcin like 1 [Source:HGNC Symbol;Acc:HGNC:5145] | 29075 | -0.252 | -0.1761 | No |
| 93 | YY1AP1 | YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] | 29187 | -0.283 | -0.1773 | No |
| 94 | CSAD | cysteine sulfinic acid decarboxylase [Source:HGNC Symbol;Acc:HGNC:18966] | 29301 | -0.311 | -0.1784 | No |
| 95 | HDAC4 | histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] | 29533 | -0.370 | -0.1823 | No |
| 96 | MAPK6 | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 29816 | -0.434 | -0.1871 | No |
| 97 | VGLL4 | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] | 29982 | -0.473 | -0.1886 | No |
| 98 | TRMT6 | tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] | 30248 | -0.554 | -0.1922 | No |
| 99 | USP5 | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] | 30403 | -0.581 | -0.1927 | No |
| 100 | GPR52 | G protein-coupled receptor 52 [Source:HGNC Symbol;Acc:HGNC:4508] | 30994 | -0.741 | -0.2039 | No |
| 101 | ABHD16A | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] | 31041 | -0.759 | -0.2003 | No |
| 102 | BBX | BBX high mobility group box domain containing [Source:HGNC Symbol;Acc:HGNC:14422] | 31111 | -0.787 | -0.1971 | No |
| 103 | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [Source:HGNC Symbol;Acc:HGNC:29289] | 31480 | -0.886 | -0.2014 | No |
| 104 | TERF2IP | TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] | 31600 | -0.925 | -0.1987 | No |
| 105 | MITF | melanocyte inducing transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] | 31915 | -1.030 | -0.2007 | No |
| 106 | PLXNC1 | plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] | 32544 | -1.270 | -0.2095 | No |
| 107 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 32843 | -1.394 | -0.2087 | No |
| 108 | TRMT112 | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] | 33117 | -1.512 | -0.2064 | No |
| 109 | ESR1 | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | 33482 | -1.593 | -0.2061 | No |
| 110 | RNF220 | ring finger protein 220 [Source:HGNC Symbol;Acc:HGNC:25552] | 33522 | -1.608 | -0.1969 | No |
| 111 | USF1 | upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] | 33728 | -1.701 | -0.1916 | No |
| 112 | DDX17 | DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740] | 33828 | -1.742 | -0.1831 | No |
| 113 | KDM3A | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] | 33998 | -1.828 | -0.1760 | No |
| 114 | AMER1 | APC membrane recruitment protein 1 [Source:HGNC Symbol;Acc:HGNC:26837] | 34001 | -1.830 | -0.1644 | No |
| 115 | DAP3 | death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673] | 34107 | -1.879 | -0.1552 | No |
| 116 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 34476 | -2.077 | -0.1519 | No |
| 117 | ARHGAP5 | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] | 34761 | -2.255 | -0.1452 | No |
| 118 | RIMS2 | regulating synaptic membrane exocytosis 2 [Source:HGNC Symbol;Acc:HGNC:17283] | 34810 | -2.285 | -0.1319 | No |
| 119 | FXYD5 | FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol;Acc:HGNC:4029] | 34832 | -2.300 | -0.1178 | No |
| 120 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:685] | 35353 | -2.629 | -0.1151 | No |
| 121 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147] | 35598 | -2.848 | -0.1035 | No |
| 122 | SIPA1 | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] | 35941 | -3.116 | -0.0929 | No |
| 123 | TNFSF13B | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] | 36082 | -3.256 | -0.0759 | No |
| 124 | FAM13C | family with sequence similarity 13 member C [Source:HGNC Symbol;Acc:HGNC:19371] | 36229 | -3.423 | -0.0579 | No |
| 125 | DEPDC7 | DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] | 36722 | -4.010 | -0.0456 | No |
| 126 | SORBS1 | sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] | 36778 | -4.092 | -0.0210 | No |
| 127 | GSDMD | gasdermin D [Source:HGNC Symbol;Acc:HGNC:25697] | 36987 | -4.607 | 0.0028 | No |
