Fig 1: Enrichment plot: ZHONG_PFC_C8_ORG_PROLIFERATING
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | ZHONG_PFC_C8_ORG_PROLIFERATING |
| Enrichment Score (ES) | -0.7914304 |
| Normalized Enrichment Score (NES) | -1.5765427 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.003286956 |
| FWER p-Value | 0.078 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MT2A | metallothionein 2A [Source:HGNC Symbol;Acc:HGNC:7406] | 322 | 3.713 | 0.0177 | No |
| 2 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 1668 | 1.672 | -0.0068 | No |
| 3 | CKS2 | CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000] | 3147 | 0.848 | -0.0407 | No |
| 4 | GAS2L3 | growth arrest specific 2 like 3 [Source:HGNC Symbol;Acc:HGNC:27475] | 3570 | 0.680 | -0.0472 | No |
| 5 | EMP3 | epithelial membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:3335] | 4206 | 0.466 | -0.0611 | No |
| 6 | NOTCH2NLA | notch 2 N-terminal like A [Source:HGNC Symbol;Acc:HGNC:31862] | 4832 | 0.278 | -0.0760 | No |
| 7 | PRR11 | proline rich 11 [Source:HGNC Symbol;Acc:HGNC:25619] | 4938 | 0.248 | -0.0771 | No |
| 8 | UNC50 | unc-50 inner nuclear membrane RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16046] | 5920 | 0.066 | -0.1031 | No |
| 9 | CCNA1 | cyclin A1 [Source:HGNC Symbol;Acc:HGNC:1577] | 7410 | 0.000 | -0.1433 | No |
| 10 | CRNDE | colorectal neoplasia differentially expressed [Source:HGNC Symbol;Acc:HGNC:37078] | 11366 | 0.000 | -0.2501 | No |
| 11 | NMU | neuromedin U [Source:HGNC Symbol;Acc:HGNC:7859] | 19347 | 0.000 | -0.4656 | No |
| 12 | SFRP2 | secreted frizzled related protein 2 [Source:HGNC Symbol;Acc:HGNC:10777] | 20632 | 0.000 | -0.5003 | No |
| 13 | ITGB1BP1 | integrin subunit beta 1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23927] | 28514 | -0.098 | -0.7124 | No |
| 14 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 30207 | -0.543 | -0.7543 | No |
| 15 | ANXA2 | annexin A2 [Source:HGNC Symbol;Acc:HGNC:537] | 30384 | -0.575 | -0.7549 | No |
| 16 | TUBB6 | tubulin beta 6 class V [Source:HGNC Symbol;Acc:HGNC:20776] | 30877 | -0.704 | -0.7632 | No |
| 17 | TXNDC12 | thioredoxin domain containing 12 [Source:HGNC Symbol;Acc:HGNC:24626] | 31922 | -1.032 | -0.7841 | Yes |
| 18 | TUBB4B | tubulin beta 4B class IVb [Source:HGNC Symbol;Acc:HGNC:20771] | 31976 | -1.055 | -0.7780 | Yes |
| 19 | PLIN3 | perilipin 3 [Source:HGNC Symbol;Acc:HGNC:16893] | 32127 | -1.105 | -0.7742 | Yes |
| 20 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 32379 | -1.207 | -0.7725 | Yes |
| 21 | TROAP | trophinin associated protein [Source:HGNC Symbol;Acc:HGNC:12327] | 33022 | -1.475 | -0.7793 | Yes |
| 22 | LGALS1 | galectin 1 [Source:HGNC Symbol;Acc:HGNC:6561] | 33426 | -1.566 | -0.7791 | Yes |
| 23 | TMEM256 | transmembrane protein 256 [Source:HGNC Symbol;Acc:HGNC:28618] | 33752 | -1.710 | -0.7757 | Yes |
| 24 | TACC3 | transforming acidic coiled-coil containing protein 3 [Source:HGNC Symbol;Acc:HGNC:11524] | 33842 | -1.752 | -0.7657 | Yes |
| 25 | CRYZ | crystallin zeta [Source:HGNC Symbol;Acc:HGNC:2419] | 34342 | -2.014 | -0.7649 | Yes |
| 26 | CCNB1 | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] | 34381 | -2.017 | -0.7516 | Yes |
| 27 | TUBA1C | tubulin alpha 1c [Source:HGNC Symbol;Acc:HGNC:20768] | 34385 | -2.024 | -0.7373 | Yes |
| 28 | ARL6IP1 | ADP ribosylation factor like GTPase 6 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:697] | 34578 | -2.137 | -0.7273 | Yes |
| 29 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 34617 | -2.156 | -0.7130 | Yes |
| 30 | MZT1 | mitotic spindle organizing protein 1 [Source:HGNC Symbol;Acc:HGNC:33830] | 34703 | -2.215 | -0.6996 | Yes |
| 31 | ODF2 | outer dense fiber of sperm tails 2 [Source:HGNC Symbol;Acc:HGNC:8114] | 34708 | -2.222 | -0.6839 | Yes |
| 32 | TPX2 | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] | 34811 | -2.286 | -0.6704 | Yes |
| 33 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 35122 | -2.440 | -0.6615 | Yes |
| 34 | KIF20A | kinesin family member 20A [Source:HGNC Symbol;Acc:HGNC:9787] | 35171 | -2.487 | -0.6451 | Yes |
| 35 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 35217 | -2.531 | -0.6284 | Yes |
| 36 | CCDC34 | coiled-coil domain containing 34 [Source:HGNC Symbol;Acc:HGNC:25079] | 35271 | -2.565 | -0.6116 | Yes |
| 37 | RP2 | RP2 activator of ARL3 GTPase [Source:HGNC Symbol;Acc:HGNC:10274] | 35490 | -2.734 | -0.5981 | Yes |
| 38 | SHCBP1 | SHC binding and spindle associated 1 [Source:HGNC Symbol;Acc:HGNC:29547] | 35789 | -2.981 | -0.5850 | Yes |
| 39 | CDCA8 | cell division cycle associated 8 [Source:HGNC Symbol;Acc:HGNC:14629] | 35792 | -2.983 | -0.5638 | Yes |
| 40 | CDCA3 | cell division cycle associated 3 [Source:HGNC Symbol;Acc:HGNC:14624] | 35805 | -2.996 | -0.5429 | Yes |
| 41 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 35809 | -2.998 | -0.5217 | Yes |
| 42 | CENPE | centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] | 35839 | -3.018 | -0.5011 | Yes |
| 43 | OIP5 | Opa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300] | 35911 | -3.088 | -0.4810 | Yes |
| 44 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 35969 | -3.152 | -0.4602 | Yes |
| 45 | SGO2 | shugoshin 2 [Source:HGNC Symbol;Acc:HGNC:30812] | 36103 | -3.290 | -0.4404 | Yes |
| 46 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 36104 | -3.290 | -0.4171 | Yes |
| 47 | CEP70 | centrosomal protein 70 [Source:HGNC Symbol;Acc:HGNC:29972] | 36114 | -3.308 | -0.3938 | Yes |
| 48 | RACGAP1 | Rac GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9804] | 36132 | -3.332 | -0.3707 | Yes |
| 49 | DCXR | dicarbonyl and L-xylulose reductase [Source:HGNC Symbol;Acc:HGNC:18985] | 36168 | -3.372 | -0.3477 | Yes |
| 50 | BIRC5 | baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] | 36250 | -3.453 | -0.3253 | Yes |
| 51 | PRC1 | protein regulator of cytokinesis 1 [Source:HGNC Symbol;Acc:HGNC:9341] | 36268 | -3.475 | -0.3011 | Yes |
| 52 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 36332 | -3.523 | -0.2778 | Yes |
| 53 | CKAP2 | cytoskeleton associated protein 2 [Source:HGNC Symbol;Acc:HGNC:1990] | 36464 | -3.673 | -0.2553 | Yes |
| 54 | KIF18A | kinesin family member 18A [Source:HGNC Symbol;Acc:HGNC:29441] | 36514 | -3.722 | -0.2302 | Yes |
| 55 | NEK2 | NIMA related kinase 2 [Source:HGNC Symbol;Acc:HGNC:7745] | 36597 | -3.856 | -0.2050 | Yes |
| 56 | NUSAP1 | nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] | 36602 | -3.862 | -0.1777 | Yes |
| 57 | DEPDC1B | DEP domain containing 1B [Source:HGNC Symbol;Acc:HGNC:24902] | 36832 | -4.186 | -0.1542 | Yes |
| 58 | CENPF | centromere protein F [Source:HGNC Symbol;Acc:HGNC:1857] | 36884 | -4.334 | -0.1248 | Yes |
| 59 | KNSTRN | kinetochore localized astrin (SPAG5) binding protein [Source:HGNC Symbol;Acc:HGNC:30767] | 36938 | -4.452 | -0.0946 | Yes |
| 60 | ASPM | assembly factor for spindle microtubules [Source:HGNC Symbol;Acc:HGNC:19048] | 36959 | -4.497 | -0.0632 | Yes |
| 61 | SMTN | smoothelin [Source:HGNC Symbol;Acc:HGNC:11126] | 37014 | -4.689 | -0.0314 | Yes |
| 62 | PSRC1 | proline and serine rich coiled-coil 1 [Source:HGNC Symbol;Acc:HGNC:24472] | 37022 | -4.704 | 0.0018 | Yes |
