Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.503513 |
| Normalized Enrichment Score (NES) | 1.3058662 |
| Nominal p-value | 0.009090909 |
| FDR q-value | 0.06875604 |
| FWER p-Value | 0.173 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 23 | 4.965 | 0.0346 | Yes |
| 2 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 42 | 4.905 | 0.0689 | Yes |
| 3 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 61 | 4.853 | 0.1028 | Yes |
| 4 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 69 | 4.814 | 0.1368 | Yes |
| 5 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 111 | 4.590 | 0.1682 | Yes |
| 6 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 122 | 4.520 | 0.2000 | Yes |
| 7 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 215 | 4.119 | 0.2267 | Yes |
| 8 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 227 | 4.065 | 0.2552 | Yes |
| 9 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 258 | 3.964 | 0.2825 | Yes |
| 10 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 313 | 3.750 | 0.3077 | Yes |
| 11 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 488 | 3.237 | 0.3259 | Yes |
| 12 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 564 | 3.084 | 0.3457 | Yes |
| 13 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 606 | 2.983 | 0.3658 | Yes |
| 14 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 610 | 2.974 | 0.3868 | Yes |
| 15 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 689 | 2.819 | 0.4047 | Yes |
| 16 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 721 | 2.746 | 0.4233 | Yes |
| 17 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 727 | 2.739 | 0.4426 | Yes |
| 18 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 1085 | 2.219 | 0.4487 | Yes |
| 19 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 1157 | 2.127 | 0.4618 | Yes |
| 20 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 1170 | 2.118 | 0.4765 | Yes |
| 21 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 1264 | 1.986 | 0.4881 | Yes |
| 22 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1848 | 1.539 | 0.4832 | Yes |
| 23 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 1985 | 1.438 | 0.4897 | Yes |
| 24 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 2294 | 1.243 | 0.4902 | Yes |
| 25 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2374 | 1.192 | 0.4965 | Yes |
| 26 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 2422 | 1.162 | 0.5035 | Yes |
| 27 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 3018 | 0.888 | 0.4937 | No |
| 28 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 3167 | 0.837 | 0.4956 | No |
| 29 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 3246 | 0.803 | 0.4992 | No |
| 30 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 3735 | 0.624 | 0.4904 | No |
| 31 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 4458 | 0.378 | 0.4736 | No |
| 32 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 4472 | 0.373 | 0.4759 | No |
| 33 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 4489 | 0.370 | 0.4781 | No |
| 34 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 4566 | 0.348 | 0.4785 | No |
| 35 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 4955 | 0.243 | 0.4697 | No |
| 36 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 4977 | 0.237 | 0.4708 | No |
| 37 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 5021 | 0.223 | 0.4712 | No |
| 38 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 5812 | 0.100 | 0.4506 | No |
| 39 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 6140 | 0.002 | 0.4417 | No |
| 40 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 6146 | 0.000 | 0.4416 | No |
| 41 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 6495 | 0.000 | 0.4322 | No |
| 42 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 9800 | 0.000 | 0.3428 | No |
| 43 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10021 | 0.000 | 0.3368 | No |
| 44 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10036 | 0.000 | 0.3364 | No |
| 45 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10038 | 0.000 | 0.3364 | No |
| 46 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10039 | 0.000 | 0.3364 | No |
| 47 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 10777 | 0.000 | 0.3165 | No |
| 48 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11059 | 0.000 | 0.3089 | No |
| 49 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11480 | 0.000 | 0.2975 | No |
| 50 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11529 | 0.000 | 0.2962 | No |
| 51 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11546 | 0.000 | 0.2958 | No |
| 52 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 12373 | 0.000 | 0.2734 | No |
| 53 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 12572 | 0.000 | 0.2681 | No |
| 54 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14034 | 0.000 | 0.2285 | No |
| 55 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15498 | 0.000 | 0.1889 | No |
| 56 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15566 | 0.000 | 0.1871 | No |
| 57 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15567 | 0.000 | 0.1871 | No |
| 58 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15569 | 0.000 | 0.1871 | No |
| 59 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15594 | 0.000 | 0.1864 | No |
| 60 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15674 | 0.000 | 0.1843 | No |
| 61 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15675 | 0.000 | 0.1843 | No |
| 62 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 15932 | 0.000 | 0.1774 | No |
| 63 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16008 | 0.000 | 0.1754 | No |
| 64 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16013 | 0.000 | 0.1752 | No |
| 65 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16057 | 0.000 | 0.1741 | No |
| 66 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 16368 | 0.000 | 0.1657 | No |
| 67 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16369 | 0.000 | 0.1657 | No |
| 68 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16370 | 0.000 | 0.1657 | No |
| 69 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16608 | 0.000 | 0.1593 | No |
| 70 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16609 | 0.000 | 0.1593 | No |
| 71 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 16655 | 0.000 | 0.1581 | No |
| 72 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16666 | 0.000 | 0.1578 | No |
| 73 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17063 | 0.000 | 0.1471 | No |
| 74 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17072 | 0.000 | 0.1469 | No |
| 75 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17435 | 0.000 | 0.1371 | No |
| 76 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17614 | 0.000 | 0.1322 | No |
| 77 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17738 | 0.000 | 0.1289 | No |
| 78 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17751 | 0.000 | 0.1286 | No |
| 79 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17911 | 0.000 | 0.1243 | No |
| 80 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19110 | 0.000 | 0.0919 | No |
| 81 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19113 | 0.000 | 0.0918 | No |
| 82 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19117 | 0.000 | 0.0917 | No |
| 83 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19123 | 0.000 | 0.0916 | No |
| 84 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20024 | 0.000 | 0.0672 | No |
| 85 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 20055 | 0.000 | 0.0664 | No |
| 86 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 20243 | 0.000 | 0.0614 | No |
| 87 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 20305 | 0.000 | 0.0597 | No |
| 88 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 20502 | 0.000 | 0.0544 | No |
| 89 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 20679 | 0.000 | 0.0497 | No |
| 90 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 22048 | 0.000 | 0.0126 | No |
| 91 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 22140 | 0.000 | 0.0102 | No |
| 92 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 22332 | 0.000 | 0.0050 | No |
| 93 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 23642 | 0.000 | -0.0304 | No |
| 94 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24230 | 0.000 | -0.0463 | No |
| 95 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 24603 | 0.000 | -0.0564 | No |
| 96 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 24703 | 0.000 | -0.0590 | No |
| 97 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 24736 | 0.000 | -0.0599 | No |
| 98 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 24795 | 0.000 | -0.0615 | No |
| 99 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 24913 | 0.000 | -0.0646 | No |
| 100 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 25221 | 0.000 | -0.0730 | No |
| 101 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 25368 | 0.000 | -0.0769 | No |
| 102 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 25600 | 0.000 | -0.0832 | No |
| 103 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 25604 | 0.000 | -0.0832 | No |
| 104 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 25609 | 0.000 | -0.0833 | No |
| 105 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 25993 | 0.000 | -0.0937 | No |
| 106 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 28655 | -0.141 | -0.1647 | No |
| 107 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 29649 | -0.401 | -0.1887 | No |
| 108 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 29862 | -0.443 | -0.1913 | No |
| 109 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 30128 | -0.518 | -0.1948 | No |
| 110 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 30464 | -0.596 | -0.1997 | No |
| 111 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 31226 | -0.822 | -0.2144 | No |
| 112 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 31235 | -0.824 | -0.2088 | No |
| 113 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 31521 | -0.904 | -0.2101 | No |
| 114 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 31853 | -1.008 | -0.2119 | No |
| 115 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 31865 | -1.011 | -0.2051 | No |
| 116 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 31949 | -1.042 | -0.1999 | No |
| 117 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 32624 | -1.298 | -0.2090 | No |
| 118 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 32815 | -1.378 | -0.2043 | No |
| 119 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 32849 | -1.399 | -0.1953 | No |
| 120 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 32954 | -1.445 | -0.1879 | No |
| 121 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 33367 | -1.535 | -0.1881 | No |
| 122 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 33542 | -1.617 | -0.1814 | No |
| 123 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 33687 | -1.684 | -0.1733 | No |
| 124 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 33735 | -1.703 | -0.1625 | No |
| 125 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 34192 | -1.927 | -0.1612 | No |
| 126 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 34327 | -2.007 | -0.1506 | No |
| 127 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 34436 | -2.055 | -0.1389 | No |
| 128 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 34530 | -2.111 | -0.1265 | No |
| 129 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 34720 | -2.232 | -0.1158 | No |
| 130 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 34740 | -2.247 | -0.1003 | No |
| 131 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 34792 | -2.274 | -0.0856 | No |
| 132 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35824 | -3.007 | -0.0922 | No |
| 133 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 35909 | -3.083 | -0.0726 | No |
| 134 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 36136 | -3.337 | -0.0550 | No |
| 135 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36283 | -3.494 | -0.0342 | No |
| 136 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 36334 | -3.526 | -0.0106 | No |
| 137 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 36904 | -4.371 | 0.0050 | No |
