Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.76045734 |
| Normalized Enrichment Score (NES) | 1.8989921 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 16 | 4.973 | 0.0432 | Yes |
| 2 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 45 | 4.889 | 0.0854 | Yes |
| 3 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 102 | 4.637 | 0.1246 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 116 | 4.554 | 0.1643 | Yes |
| 5 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 123 | 4.514 | 0.2037 | Yes |
| 6 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 150 | 4.382 | 0.2415 | Yes |
| 7 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 242 | 4.026 | 0.2744 | Yes |
| 8 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 252 | 3.978 | 0.3091 | Yes |
| 9 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 308 | 3.777 | 0.3408 | Yes |
| 10 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 351 | 3.623 | 0.3714 | Yes |
| 11 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 434 | 3.401 | 0.3991 | Yes |
| 12 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 501 | 3.205 | 0.4254 | Yes |
| 13 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 571 | 3.068 | 0.4505 | Yes |
| 14 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 607 | 2.982 | 0.4758 | Yes |
| 15 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 707 | 2.773 | 0.4974 | Yes |
| 16 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 715 | 2.761 | 0.5215 | Yes |
| 17 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 773 | 2.648 | 0.5432 | Yes |
| 18 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 830 | 2.613 | 0.5646 | Yes |
| 19 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 935 | 2.452 | 0.5834 | Yes |
| 20 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 1010 | 2.323 | 0.6018 | Yes |
| 21 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 1127 | 2.155 | 0.6176 | Yes |
| 22 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 1184 | 2.092 | 0.6344 | Yes |
| 23 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1236 | 2.021 | 0.6508 | Yes |
| 24 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1237 | 2.020 | 0.6685 | Yes |
| 25 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 1275 | 1.977 | 0.6849 | Yes |
| 26 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1313 | 1.940 | 0.7009 | Yes |
| 27 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 1319 | 1.930 | 0.7177 | Yes |
| 28 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1338 | 1.913 | 0.7340 | Yes |
| 29 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 1476 | 1.802 | 0.7462 | Yes |
| 30 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1848 | 1.539 | 0.7496 | Yes |
| 31 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 2596 | 1.091 | 0.7390 | Yes |
| 32 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 2630 | 1.073 | 0.7476 | Yes |
| 33 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 2850 | 0.966 | 0.7501 | Yes |
| 34 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 2884 | 0.952 | 0.7576 | Yes |
| 35 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 3061 | 0.866 | 0.7605 | Yes |
| 36 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 3890 | 0.569 | 0.7431 | No |
| 37 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 4176 | 0.478 | 0.7396 | No |
| 38 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 4192 | 0.471 | 0.7433 | No |
| 39 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 4738 | 0.303 | 0.7312 | No |
| 40 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 4951 | 0.245 | 0.7277 | No |
| 41 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 5232 | 0.162 | 0.7215 | No |
| 42 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 5820 | 0.099 | 0.7065 | No |
| 43 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 6146 | 0.000 | 0.6977 | No |
| 44 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 7830 | 0.000 | 0.6523 | No |
| 45 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 8667 | 0.000 | 0.6297 | No |
| 46 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9152 | 0.000 | 0.6166 | No |
| 47 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 10822 | 0.000 | 0.5715 | No |
| 48 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 11352 | 0.000 | 0.5572 | No |
| 49 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11593 | 0.000 | 0.5507 | No |
| 50 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 11902 | 0.000 | 0.5424 | No |
| 51 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13428 | 0.000 | 0.5012 | No |
| 52 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13756 | 0.000 | 0.4923 | No |
| 53 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 13828 | 0.000 | 0.4904 | No |
| 54 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14076 | 0.000 | 0.4837 | No |
| 55 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 14954 | 0.000 | 0.4600 | No |
| 56 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15011 | 0.000 | 0.4585 | No |
| 57 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15516 | 0.000 | 0.4449 | No |
| 58 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15797 | 0.000 | 0.4373 | No |
| 59 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15798 | 0.000 | 0.4373 | No |
| 60 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16441 | 0.000 | 0.4200 | No |
| 61 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18455 | 0.000 | 0.3656 | No |
| 62 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18877 | 0.000 | 0.3542 | No |
| 63 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18917 | 0.000 | 0.3531 | No |
| 64 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19007 | 0.000 | 0.3507 | No |
| 65 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19465 | 0.000 | 0.3384 | No |
| 66 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19477 | 0.000 | 0.3381 | No |
| 67 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19479 | 0.000 | 0.3381 | No |
| 68 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19643 | 0.000 | 0.3337 | No |
| 69 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20024 | 0.000 | 0.3234 | No |
| 70 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 21576 | 0.000 | 0.2815 | No |
| 71 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 23592 | 0.000 | 0.2270 | No |
| 72 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24230 | 0.000 | 0.2098 | No |
| 73 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 25045 | 0.000 | 0.1878 | No |
| 74 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 25201 | 0.000 | 0.1836 | No |
| 75 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 25203 | 0.000 | 0.1836 | No |
| 76 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 27832 | 0.000 | 0.1126 | No |
| 77 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 27933 | 0.000 | 0.1099 | No |
| 78 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 29657 | -0.403 | 0.0669 | No |
| 79 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 30277 | -0.561 | 0.0551 | No |
| 80 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 31252 | -0.833 | 0.0361 | No |
| 81 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 31717 | -0.967 | 0.0320 | No |
| 82 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 33124 | -1.518 | 0.0073 | No |
| 83 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 33526 | -1.610 | 0.0106 | No |
| 84 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 34060 | -1.864 | 0.0126 | No |
| 85 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 34202 | -1.930 | 0.0257 | No |
| 86 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 34631 | -2.169 | 0.0332 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 36545 | -3.782 | 0.0147 | No |
