Fig 1: Enrichment plot: HALLMARK_MYC_TARGETS_V2
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | HALLMARK_MYC_TARGETS_V2 |
| Enrichment Score (ES) | 0.37044325 |
| Normalized Enrichment Score (NES) | 0.86458784 |
| Nominal p-value | 0.8194444 |
| FDR q-value | 0.87900674 |
| FWER p-Value | 0.995 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | DUSP2 | dual specificity phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:3068] | 101 | 4.641 | 0.0548 | Yes |
| 2 | MYC | MYC proto-oncogene, bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] | 134 | 4.461 | 0.1093 | Yes |
| 3 | GRWD1 | glutamate rich WD repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:21270] | 906 | 2.504 | 0.1195 | Yes |
| 4 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 1089 | 2.212 | 0.1421 | Yes |
| 5 | IPO4 | importin 4 [Source:HGNC Symbol;Acc:HGNC:19426] | 1133 | 2.147 | 0.1675 | Yes |
| 6 | UTP20 | UTP20 small subunit processome component [Source:HGNC Symbol;Acc:HGNC:17897] | 1627 | 1.731 | 0.1757 | Yes |
| 7 | RRP12 | ribosomal RNA processing 12 homolog [Source:HGNC Symbol;Acc:HGNC:29100] | 1781 | 1.584 | 0.1912 | Yes |
| 8 | NOP2 | NOP2 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:7867] | 1849 | 1.539 | 0.2085 | Yes |
| 9 | HSPE1 | heat shock protein family E (Hsp10) member 1 [Source:HGNC Symbol;Acc:HGNC:5269] | 1913 | 1.501 | 0.2254 | Yes |
| 10 | NOP16 | NOP16 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:26934] | 2022 | 1.408 | 0.2400 | Yes |
| 11 | FARSA | phenylalanyl-tRNA synthetase subunit alpha [Source:HGNC Symbol;Acc:HGNC:3592] | 2034 | 1.401 | 0.2571 | Yes |
| 12 | HK2 | hexokinase 2 [Source:HGNC Symbol;Acc:HGNC:4923] | 2126 | 1.338 | 0.2712 | Yes |
| 13 | MRTO4 | MRT4 homolog, ribosome maturation factor [Source:HGNC Symbol;Acc:HGNC:18477] | 2156 | 1.321 | 0.2868 | Yes |
| 14 | WDR43 | WD repeat domain 43 [Source:HGNC Symbol;Acc:HGNC:28945] | 2378 | 1.190 | 0.2956 | Yes |
| 15 | PUS1 | pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:15508] | 2379 | 1.189 | 0.3103 | Yes |
| 16 | NIP7 | nucleolar pre-rRNA processing protein NIP7 [Source:HGNC Symbol;Acc:HGNC:24328] | 2394 | 1.181 | 0.3246 | Yes |
| 17 | PPRC1 | PPARG related coactivator 1 [Source:HGNC Symbol;Acc:HGNC:30025] | 2760 | 1.005 | 0.3272 | Yes |
| 18 | BYSL | bystin like [Source:HGNC Symbol;Acc:HGNC:1157] | 2895 | 0.946 | 0.3353 | Yes |
| 19 | TCOF1 | treacle ribosome biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:11654] | 3124 | 0.858 | 0.3398 | Yes |
| 20 | MYBBP1A | MYB binding protein 1a [Source:HGNC Symbol;Acc:HGNC:7546] | 3155 | 0.844 | 0.3495 | Yes |
| 21 | PA2G4 | proliferation-associated 2G4 [Source:HGNC Symbol;Acc:HGNC:8550] | 3331 | 0.769 | 0.3543 | Yes |
| 22 | PHB | prohibitin [Source:HGNC Symbol;Acc:HGNC:8912] | 3555 | 0.685 | 0.3568 | Yes |
| 23 | HSPD1 | heat shock protein family D (Hsp60) member 1 [Source:HGNC Symbol;Acc:HGNC:5261] | 3600 | 0.670 | 0.3639 | Yes |
| 24 | IMP4 | IMP U3 small nucleolar ribonucleoprotein 4 [Source:HGNC Symbol;Acc:HGNC:30856] | 3657 | 0.650 | 0.3704 | Yes |
| 25 | DDX18 | DEAD-box helicase 18 [Source:HGNC Symbol;Acc:HGNC:2741] | 3936 | 0.559 | 0.3699 | No |
| 26 | PES1 | pescadillo ribosomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8848] | 4635 | 0.330 | 0.3551 | No |
| 27 | RCL1 | RNA terminal phosphate cyclase like 1 [Source:HGNC Symbol;Acc:HGNC:17687] | 4670 | 0.322 | 0.3582 | No |
| 28 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 4692 | 0.315 | 0.3615 | No |
| 29 | TBRG4 | transforming growth factor beta regulator 4 [Source:HGNC Symbol;Acc:HGNC:17443] | 4936 | 0.248 | 0.3580 | No |
| 30 | SRM | spermidine synthase [Source:HGNC Symbol;Acc:HGNC:11296] | 5009 | 0.226 | 0.3589 | No |
| 31 | MPHOSPH10 | M-phase phosphoprotein 10 [Source:HGNC Symbol;Acc:HGNC:7213] | 5066 | 0.209 | 0.3600 | No |
| 32 | AIMP2 | aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [Source:HGNC Symbol;Acc:HGNC:20609] | 5107 | 0.199 | 0.3614 | No |
| 33 | LAS1L | LAS1 like ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:25726] | 5111 | 0.198 | 0.3637 | No |
| 34 | NOC4L | nucleolar complex associated 4 homolog [Source:HGNC Symbol;Acc:HGNC:28461] | 5195 | 0.172 | 0.3636 | No |
| 35 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 5986 | 0.044 | 0.3428 | No |
| 36 | PPAN | peter pan homolog [Source:HGNC Symbol;Acc:HGNC:9227] | 28265 | -0.027 | -0.2584 | No |
| 37 | GNL3 | G protein nucleolar 3 [Source:HGNC Symbol;Acc:HGNC:29931] | 28345 | -0.047 | -0.2600 | No |
| 38 | WDR74 | WD repeat domain 74 [Source:HGNC Symbol;Acc:HGNC:25529] | 28359 | -0.052 | -0.2597 | No |
| 39 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 28681 | -0.147 | -0.2665 | No |
| 40 | SLC19A1 | solute carrier family 19 member 1 [Source:HGNC Symbol;Acc:HGNC:10937] | 29079 | -0.253 | -0.2741 | No |
| 41 | PRMT3 | protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163] | 31223 | -0.822 | -0.3218 | No |
| 42 | TMEM97 | transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] | 31439 | -0.871 | -0.3168 | No |
| 43 | RABEPK | Rab9 effector protein with kelch motifs [Source:HGNC Symbol;Acc:HGNC:16896] | 31617 | -0.934 | -0.3100 | No |
| 44 | DCTPP1 | dCTP pyrophosphatase 1 [Source:HGNC Symbol;Acc:HGNC:28777] | 31700 | -0.964 | -0.3002 | No |
| 45 | TFB2M | transcription factor B2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:18559] | 32109 | -1.105 | -0.2975 | No |
| 46 | SUPV3L1 | Suv3 like RNA helicase [Source:HGNC Symbol;Acc:HGNC:11471] | 32766 | -1.356 | -0.2984 | No |
| 47 | NDUFAF4 | NADH:ubiquinone oxidoreductase complex assembly factor 4 [Source:HGNC Symbol;Acc:HGNC:21034] | 33349 | -1.530 | -0.2951 | No |
| 48 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 33683 | -1.683 | -0.2833 | No |
| 49 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 33985 | -1.823 | -0.2688 | No |
| 50 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34046 | -1.854 | -0.2474 | No |
| 51 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 34248 | -1.957 | -0.2286 | No |
| 52 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35379 | -2.657 | -0.2261 | No |
| 53 | SLC29A2 | solute carrier family 29 member 2 [Source:HGNC Symbol;Acc:HGNC:11004] | 35488 | -2.732 | -0.1951 | No |
| 54 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 35969 | -3.152 | -0.1690 | No |
| 55 | SORD | sorbitol dehydrogenase [Source:HGNC Symbol;Acc:HGNC:11184] | 36354 | -3.546 | -0.1354 | No |
| 56 | CBX3 | chromobox 3 [Source:HGNC Symbol;Acc:HGNC:1553] | 36526 | -3.754 | -0.0935 | No |
| 57 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 36844 | -4.220 | -0.0497 | No |
| 58 | MAP3K6 | mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6858] | 36969 | -4.539 | 0.0033 | No |
