Datasetgreenberg_collapsed_to_symbols.Nof1.cls
#WT_LPS_versus_WT_NA.Nof1.cls
#WT_LPS_versus_WT_NA_repos
PhenotypeNof1.cls#WT_LPS_versus_WT_NA_repos
Upregulated in classWT_LPS
GeneSetHALLMARK_PI3K_AKT_MTOR_SIGNALING
Enrichment Score (ES)0.3539744
Normalized Enrichment Score (NES)0.89430034
Nominal p-value0.79310346
FDR q-value0.85888964
FWER p-Value0.992
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_PI3K_AKT_MTOR_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1STAT2signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363]3083.7770.0236Yes
2NFKBIBNFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798]4373.3930.0488Yes
3SQSTM1sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280]5393.0980.0722Yes
4MYD88MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562]6072.9820.0956Yes
5MAP2K3mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843]6722.8610.1180Yes
6LCKLCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524]6922.8120.1412Yes
7IL2RGinterleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010]9352.4520.1554Yes
8NOD1nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390]11282.1540.1684Yes
9TNFRSF1ATNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916]12372.0200.1825Yes
10TRIB3tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228]17541.6040.1821Yes
11PAK4p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059]18121.5650.1938Yes
12CFL1cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874]19121.5020.2038Yes
13SLC2A1solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005]19451.4760.2154Yes
14ACTR3actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170]19511.4690.2276Yes
15CDKN1Acyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784]19701.4560.2395Yes
16UBE2D3ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476]20931.3680.2477Yes
17TRAF2TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032]21011.3640.2590Yes
18PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988]21321.3350.2695Yes
19ACTR2actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169]21461.3310.2804Yes
20CALRcalreticulin [Source:HGNC Symbol;Acc:HGNC:1455]21521.3270.2915Yes
21PFN1profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881]26351.0690.2874Yes
22PTPN11protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644]30610.8660.2833Yes
23RIT1Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023]30640.8650.2905Yes
24AP2M1adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564]31270.8560.2961Yes
25PPP2R1Bprotein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303]31320.8540.3032Yes
26IRAK4interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967]32030.8200.3082Yes
27YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849]32880.7860.3126Yes
28TBK1TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584]33020.7810.3188Yes
29DDIT3DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726]33480.7590.3240Yes
30ARPC3actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706]33930.7430.3291Yes
31ARF1ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652]34560.7180.3335Yes
32PPP1CAprotein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281]36300.6580.3344Yes
33ECSITECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548]37100.6310.3376Yes
34AKT1S1AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426]37590.6170.3415Yes
35TSC2TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363]37630.6160.3466Yes
36UBE2Nubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492]39140.5650.3473Yes
37ARHGDIARho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678]39800.5440.3501Yes
38ADCY2adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233]40650.5130.3522Yes
39RPTORregulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287]42050.4660.3524Yes
40CSNK2Bcasein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460]42840.4380.3540Yes
41RAC1Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801]44720.3730.3521No
42CAB39calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292]47270.3060.3478No
43GSK3Bglycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617]48140.2820.3478No
44GRB2growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566]49510.2450.3462No
45RIPK1receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019]52420.1600.3397No
46CLTCclathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092]56970.1390.3286No
47NCK1NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664]57960.1040.3269No
48RALBRAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840]58800.0790.3253No
49PRKAA2protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377]66130.0000.3055No
50FGF22fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679]67310.0000.3023No
51FGF17fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673]67340.0000.3023No
52PITX2paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005]71840.0000.2901No
53CAMK4calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464]89630.0000.2421No
54GNGT1G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411]161820.0000.0469No
55IL4interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014]176810.0000.0064No
56NGFnerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808]192950.000-0.0372No
57FGF6fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684]225770.000-0.1259No
58PLCB1phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917]232580.000-0.1443No
59GNA14G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382]240260.000-0.1650No
60FASLGFas ligand [Source:HGNC Symbol;Acc:HGNC:11936]249470.000-0.1899No
61EGFRepidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]270210.000-0.2460No
62THEM4thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947]277730.000-0.2663No
63CAB39Lcalcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290]28200-0.009-0.2777No
64ATF1activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783]28503-0.096-0.2851No
65MAP3K7mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859]28758-0.169-0.2905No
66RAF1Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829]28820-0.184-0.2906No
67SMAD2SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768]29005-0.233-0.2936No
68PRKCBprotein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395]29215-0.291-0.2968No
69EIF4Eeukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287]29458-0.350-0.3004No
70HSP90B1heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028]29633-0.398-0.3017No
71AKT1AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391]29811-0.434-0.3029No
72TIAM1TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805]29900-0.455-0.3014No
73PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385]30123-0.517-0.3030No
74MAPK8mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881]30160-0.529-0.2995No
75PIKFYVEphosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785]30591-0.631-0.3058No
76SLASrc like adaptor [Source:HGNC Symbol;Acc:HGNC:10902]30678-0.653-0.3027No
77MAPKAP1MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752]30685-0.655-0.2973No
78HRASHRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173]30836-0.689-0.2955No
79SFNstratifin [Source:HGNC Symbol;Acc:HGNC:10773]30897-0.712-0.2911No
80MKNK1MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110]30954-0.728-0.2865No
81PTENphosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]30988-0.737-0.2812No
82MAPK9mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886]31542-0.908-0.2885No
83RPS6KA3ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432]31563-0.914-0.2813No
84MAPK1mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871]31615-0.933-0.2748No
85CDK1cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722]32153-1.113-0.2799No
86RPS6KA1ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430]32479-1.240-0.2782No
87GRK2G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289]32525-1.262-0.2688No
88ACACAacetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84]33063-1.493-0.2707No
89PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391]33394-1.552-0.2665No
90DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500]33527-1.611-0.2565No
91DUSP3dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069]33558-1.624-0.2436No
92MKNK2MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111]33682-1.682-0.2327No
93CDK4cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773]33985-1.823-0.2255No
94MAPK10mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872]34098-1.874-0.2127No
95CDKN1Bcyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785]34171-1.915-0.1984No
96VAV3vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659]34193-1.927-0.1827No
97ITPR2inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181]34774-2.260-0.1793No
98CDK2cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771]34829-2.298-0.1614No
99CXCR4C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561]35311-2.596-0.1525No
100PIK3R3phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981]35586-2.831-0.1360No
101PLA2G12Aphospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554]36210-3.410-0.1240No
102E2F1E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113]36631-3.907-0.1024No
103PLCG1phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065]36915-4.395-0.0729No
104PDK1pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809]36947-4.472-0.0360No
105MAP2K6mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]37027-4.7200.0017No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_PI3K_AKT_MTOR_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_PI3K_AKT_MTOR_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_PI3K_AKT_MTOR_SIGNALING