Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.5158883 |
| Normalized Enrichment Score (NES) | -1.0709131 |
| Nominal p-value | 0.32336017 |
| FDR q-value | 0.6930744 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 154 | 4.370 | 0.0427 | No |
| 2 | M6PR | mannose-6-phosphate receptor, cation dependent [Source:HGNC Symbol;Acc:HGNC:6752] | 1210 | 2.049 | 0.0362 | No |
| 3 | DST | dystonin [Source:HGNC Symbol;Acc:HGNC:1090] | 1250 | 2.005 | 0.0566 | No |
| 4 | CTSC | cathepsin C [Source:HGNC Symbol;Acc:HGNC:2528] | 1411 | 1.824 | 0.0719 | No |
| 5 | VAMP3 | vesicle associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 1733 | 1.616 | 0.0805 | No |
| 6 | STX12 | syntaxin 12 [Source:HGNC Symbol;Acc:HGNC:11430] | 1799 | 1.570 | 0.0956 | No |
| 7 | ATP6V1H | ATPase H+ transporting V1 subunit H [Source:HGNC Symbol;Acc:HGNC:18303] | 2270 | 1.255 | 0.0964 | No |
| 8 | YKT6 | YKT6 v-SNARE homolog [Source:HGNC Symbol;Acc:HGNC:16959] | 2727 | 1.018 | 0.0950 | No |
| 9 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 2894 | 0.947 | 0.1006 | No |
| 10 | RAB22A | RAB22A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9764] | 2994 | 0.897 | 0.1076 | No |
| 11 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 3127 | 0.856 | 0.1132 | No |
| 12 | ARFGEF1 | ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:15772] | 3299 | 0.782 | 0.1170 | No |
| 13 | AP2B1 | adaptor related protein complex 2 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:563] | 3402 | 0.739 | 0.1221 | No |
| 14 | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] | 3448 | 0.721 | 0.1287 | No |
| 15 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 3456 | 0.718 | 0.1362 | No |
| 16 | ATP7A | ATPase copper transporting alpha [Source:HGNC Symbol;Acc:HGNC:869] | 3546 | 0.692 | 0.1412 | No |
| 17 | RAB2A | RAB2A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9763] | 3971 | 0.546 | 0.1356 | No |
| 18 | TMX1 | thioredoxin related transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:15487] | 4300 | 0.428 | 0.1313 | No |
| 19 | SNX2 | sorting nexin 2 [Source:HGNC Symbol;Acc:HGNC:11173] | 4719 | 0.309 | 0.1233 | No |
| 20 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 4955 | 0.243 | 0.1196 | No |
| 21 | LMAN1 | lectin, mannose binding 1 [Source:HGNC Symbol;Acc:HGNC:6631] | 4986 | 0.234 | 0.1213 | No |
| 22 | RER1 | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 5056 | 0.213 | 0.1217 | No |
| 23 | STX16 | syntaxin 16 [Source:HGNC Symbol;Acc:HGNC:11431] | 5091 | 0.202 | 0.1229 | No |
| 24 | IGF2R | insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] | 5144 | 0.189 | 0.1236 | No |
| 25 | GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4181] | 5194 | 0.172 | 0.1241 | No |
| 26 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 5697 | 0.139 | 0.1120 | No |
| 27 | TPD52 | tumor protein D52 [Source:HGNC Symbol;Acc:HGNC:12005] | 5775 | 0.110 | 0.1111 | No |
| 28 | RAB5A | RAB5A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9783] | 5781 | 0.108 | 0.1121 | No |
| 29 | ARCN1 | archain 1 [Source:HGNC Symbol;Acc:HGNC:649] | 5823 | 0.098 | 0.1121 | No |
| 30 | USO1 | USO1 vesicle transport factor [Source:HGNC Symbol;Acc:HGNC:30904] | 5952 | 0.057 | 0.1092 | No |
| 31 | TSPAN8 | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] | 11450 | 0.000 | -0.0394 | No |
| 32 | SCRN1 | secernin 1 [Source:HGNC Symbol;Acc:HGNC:22192] | 14004 | 0.000 | -0.1084 | No |
| 33 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 24355 | 0.000 | -0.3881 | No |
| 34 | KRT18 | keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430] | 26847 | 0.000 | -0.4555 | No |
| 35 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 27021 | 0.000 | -0.4602 | No |
| 36 | CD63 | CD63 molecule [Source:HGNC Symbol;Acc:HGNC:1692] | 28234 | -0.019 | -0.4927 | No |
| 37 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:799] | 28327 | -0.043 | -0.4947 | No |
| 38 | AP1G1 | adaptor related protein complex 1 subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:555] | 28369 | -0.056 | -0.4952 | No |
| 39 | TMED2 | transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] | 28400 | -0.066 | -0.4953 | No |
| 40 | AP2S1 | adaptor related protein complex 2 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:565] | 28476 | -0.089 | -0.4964 | No |
| 41 | KIF1B | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 28496 | -0.094 | -0.4959 | No |
| 42 | STAM | signal transducing adaptor molecule [Source:HGNC Symbol;Acc:HGNC:11357] | 28501 | -0.095 | -0.4950 | No |
| 43 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28520 | -0.100 | -0.4944 | No |
| 44 | NAPA | NSF attachment protein alpha [Source:HGNC Symbol;Acc:HGNC:7641] | 28667 | -0.144 | -0.4968 | No |
| 45 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28750 | -0.168 | -0.4972 | No |
| 46 | TSG101 | tumor susceptibility 101 [Source:HGNC Symbol;Acc:HGNC:15971] | 28773 | -0.173 | -0.4960 | No |
| 47 | OCRL | OCRL inositol polyphosphate-5-phosphatase [Source:HGNC Symbol;Acc:HGNC:8108] | 29160 | -0.277 | -0.5035 | No |
| 48 | COPB1 | COPI coat complex subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:2231] | 29621 | -0.395 | -0.5116 | Yes |
| 49 | YIPF6 | Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304] | 29659 | -0.403 | -0.5083 | Yes |
| 50 | COPB2 | COPI coat complex subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:2232] | 29790 | -0.428 | -0.5072 | Yes |
| 51 | TMED10 | transmembrane p24 trafficking protein 10 [Source:HGNC Symbol;Acc:HGNC:16998] | 29844 | -0.439 | -0.5040 | Yes |
| 52 | SCAMP3 | secretory carrier membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:10565] | 29921 | -0.461 | -0.5011 | Yes |
| 53 | ERGIC3 | ERGIC and golgi 3 [Source:HGNC Symbol;Acc:HGNC:15927] | 29953 | -0.469 | -0.4969 | Yes |
| 54 | ARFIP1 | ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] | 30058 | -0.499 | -0.4943 | Yes |
| 55 | RAB14 | RAB14, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16524] | 30124 | -0.517 | -0.4905 | Yes |
| 56 | GNAS | GNAS complex locus [Source:HGNC Symbol;Acc:HGNC:4392] | 30250 | -0.555 | -0.4880 | Yes |
| 57 | CLN5 | CLN5 intracellular trafficking protein [Source:HGNC Symbol;Acc:HGNC:2076] | 30271 | -0.560 | -0.4825 | Yes |
| 58 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 30358 | -0.568 | -0.4787 | Yes |
| 59 | SNAP23 | synaptosome associated protein 23 [Source:HGNC Symbol;Acc:HGNC:11131] | 30485 | -0.602 | -0.4757 | Yes |
| 60 | ANP32E | acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol;Acc:HGNC:16673] | 30578 | -0.627 | -0.4714 | Yes |
| 61 | STX7 | syntaxin 7 [Source:HGNC Symbol;Acc:HGNC:11442] | 30601 | -0.634 | -0.4652 | Yes |
| 62 | BET1 | Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562] | 30665 | -0.650 | -0.4600 | Yes |
| 63 | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol;Acc:HGNC:29177] | 30671 | -0.651 | -0.4531 | Yes |
| 64 | COG2 | component of oligomeric golgi complex 2 [Source:HGNC Symbol;Acc:HGNC:6546] | 30815 | -0.684 | -0.4496 | Yes |
| 65 | ZW10 | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] | 30974 | -0.734 | -0.4460 | Yes |
| 66 | AP3S1 | adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013] | 31052 | -0.766 | -0.4399 | Yes |
| 67 | CLTA | clathrin light chain A [Source:HGNC Symbol;Acc:HGNC:2090] | 31119 | -0.789 | -0.4332 | Yes |
| 68 | VAMP7 | vesicle associated membrane protein 7 [Source:HGNC Symbol;Acc:HGNC:11486] | 31234 | -0.824 | -0.4275 | Yes |
| 69 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 31563 | -0.914 | -0.4265 | Yes |
| 70 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 31615 | -0.933 | -0.4179 | Yes |
| 71 | GOLGA4 | golgin A4 [Source:HGNC Symbol;Acc:HGNC:4427] | 31663 | -0.950 | -0.4090 | Yes |
| 72 | SEC24D | SEC24 homolog D, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10706] | 31672 | -0.954 | -0.3990 | Yes |
| 73 | ARFGAP3 | ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:661] | 32062 | -1.090 | -0.3978 | Yes |
| 74 | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1 [Source:HGNC Symbol;Acc:HGNC:10831] | 32099 | -1.105 | -0.3869 | Yes |
| 75 | DOP1A | DOP1 leucine zipper like protein A [Source:HGNC Symbol;Acc:HGNC:21194] | 32136 | -1.107 | -0.3760 | Yes |
| 76 | COPE | COPI coat complex subunit epsilon [Source:HGNC Symbol;Acc:HGNC:2234] | 32154 | -1.113 | -0.3645 | Yes |
| 77 | DNM1L | dynamin 1 like [Source:HGNC Symbol;Acc:HGNC:2973] | 32929 | -1.436 | -0.3700 | Yes |
| 78 | NAPG | NSF attachment protein gamma [Source:HGNC Symbol;Acc:HGNC:7642] | 33090 | -1.503 | -0.3582 | Yes |
| 79 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 33446 | -1.575 | -0.3509 | Yes |
| 80 | AP3B1 | adaptor related protein complex 3 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:566] | 33503 | -1.604 | -0.3353 | Yes |
| 81 | ADAM10 | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] | 33661 | -1.670 | -0.3216 | Yes |
| 82 | RAB9A | RAB9A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9792] | 33784 | -1.724 | -0.3064 | Yes |
| 83 | VPS45 | vacuolar protein sorting 45 homolog [Source:HGNC Symbol;Acc:HGNC:14579] | 33901 | -1.780 | -0.2904 | Yes |
| 84 | PAM | peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol;Acc:HGNC:8596] | 33939 | -1.799 | -0.2721 | Yes |
| 85 | CLCN3 | chloride voltage-gated channel 3 [Source:HGNC Symbol;Acc:HGNC:2021] | 34008 | -1.833 | -0.2543 | Yes |
| 86 | SGMS1 | sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] | 34421 | -2.047 | -0.2435 | Yes |
| 87 | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:15853] | 34471 | -2.073 | -0.2226 | Yes |
| 88 | SCAMP1 | secretory carrier membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:10563] | 34727 | -2.239 | -0.2054 | Yes |
| 89 | TOM1L1 | target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] | 35163 | -2.484 | -0.1906 | Yes |
| 90 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35210 | -2.523 | -0.1647 | Yes |
| 91 | VAMP4 | vesicle associated membrane protein 4 [Source:HGNC Symbol;Acc:HGNC:12645] | 35382 | -2.658 | -0.1408 | Yes |
| 92 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 35592 | -2.837 | -0.1161 | Yes |
| 93 | ATP6V1B1 | ATPase H+ transporting V1 subunit B1 [Source:HGNC Symbol;Acc:HGNC:853] | 35923 | -3.093 | -0.0918 | Yes |
| 94 | ICA1 | islet cell autoantigen 1 [Source:HGNC Symbol;Acc:HGNC:5343] | 36331 | -3.520 | -0.0650 | Yes |
| 95 | CAV2 | caveolin 2 [Source:HGNC Symbol;Acc:HGNC:1528] | 36497 | -3.692 | -0.0299 | Yes |
| 96 | BNIP3 | BCL2 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1084] | 36865 | -4.278 | 0.0061 | Yes |
