Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_SPERMATOGENESIS |
| Enrichment Score (ES) | -0.6409239 |
| Normalized Enrichment Score (NES) | -1.375382 |
| Nominal p-value | 0.01010101 |
| FDR q-value | 0.10885075 |
| FWER p-Value | 0.379 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL13RA2 | interleukin 13 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:5975] | 241 | 4.028 | 0.0259 | No |
| 2 | DPEP3 | dipeptidase 3 [Source:HGNC Symbol;Acc:HGNC:23029] | 347 | 3.635 | 0.0523 | No |
| 3 | OAZ3 | ornithine decarboxylase antizyme 3 [Source:HGNC Symbol;Acc:HGNC:8097] | 928 | 2.467 | 0.0564 | No |
| 4 | CNIH2 | cornichon family AMPA receptor auxiliary protein 2 [Source:HGNC Symbol;Acc:HGNC:28744] | 1146 | 2.130 | 0.0677 | No |
| 5 | ELOVL3 | ELOVL fatty acid elongase 3 [Source:HGNC Symbol;Acc:HGNC:18047] | 1565 | 1.796 | 0.0708 | No |
| 6 | TLE4 | TLE family member 4, transcriptional corepressor [Source:HGNC Symbol;Acc:HGNC:11840] | 2925 | 0.931 | 0.0415 | No |
| 7 | PGS1 | phosphatidylglycerophosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:30029] | 3303 | 0.780 | 0.0376 | No |
| 8 | COIL | coilin [Source:HGNC Symbol;Acc:HGNC:2184] | 3648 | 0.651 | 0.0335 | No |
| 9 | RAD17 | RAD17 checkpoint clamp loader component [Source:HGNC Symbol;Acc:HGNC:9807] | 3849 | 0.581 | 0.0328 | No |
| 10 | TEKT2 | tektin 2 [Source:HGNC Symbol;Acc:HGNC:11725] | 3942 | 0.556 | 0.0348 | No |
| 11 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 4192 | 0.471 | 0.0318 | No |
| 12 | HSPA1L | heat shock protein family A (Hsp70) member 1 like [Source:HGNC Symbol;Acc:HGNC:5234] | 4231 | 0.455 | 0.0344 | No |
| 13 | PAPOLB | poly(A) polymerase beta [Source:HGNC Symbol;Acc:HGNC:15970] | 4435 | 0.384 | 0.0320 | No |
| 14 | AGFG1 | ArfGAP with FG repeats 1 [Source:HGNC Symbol;Acc:HGNC:5175] | 4686 | 0.317 | 0.0278 | No |
| 15 | NAA11 | N-alpha-acetyltransferase 11, NatA catalytic subunit [Source:HGNC Symbol;Acc:HGNC:28125] | 4701 | 0.314 | 0.0300 | No |
| 16 | CCT6B | chaperonin containing TCP1 subunit 6B [Source:HGNC Symbol;Acc:HGNC:1621] | 4722 | 0.308 | 0.0319 | No |
| 17 | CSNK2A2 | casein kinase 2 alpha 2 [Source:HGNC Symbol;Acc:HGNC:2459] | 5028 | 0.221 | 0.0254 | No |
| 18 | TSN | translin [Source:HGNC Symbol;Acc:HGNC:12379] | 5745 | 0.120 | 0.0070 | No |
| 19 | IP6K1 | inositol hexakisphosphate kinase 1 [Source:HGNC Symbol;Acc:HGNC:18360] | 5859 | 0.086 | 0.0046 | No |
| 20 | SCG5 | secretogranin V [Source:HGNC Symbol;Acc:HGNC:10816] | 6368 | 0.000 | -0.0091 | No |
| 21 | SCG3 | secretogranin III [Source:HGNC Symbol;Acc:HGNC:13707] | 6370 | 0.000 | -0.0091 | No |
| 22 | ADCYAP1 | adenylate cyclase activating polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:241] | 7189 | 0.000 | -0.0313 | No |
| 23 | ART3 | ADP-ribosyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:725] | 7301 | 0.000 | -0.0343 | No |
| 24 | CCNA1 | cyclin A1 [Source:HGNC Symbol;Acc:HGNC:1577] | 7410 | 0.000 | -0.0372 | No |
| 25 | ZC2HC1C | zinc finger C2HC-type containing 1C [Source:HGNC Symbol;Acc:HGNC:20354] | 8133 | 0.000 | -0.0567 | No |
| 26 | HOXB1 | homeobox B1 [Source:HGNC Symbol;Acc:HGNC:5111] | 8702 | 0.000 | -0.0721 | No |
| 27 | ADAM2 | ADAM metallopeptidase domain 2 [Source:HGNC Symbol;Acc:HGNC:198] | 8783 | 0.000 | -0.0743 | No |
| 28 | ADAD1 | adenosine deaminase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30713] | 8940 | 0.000 | -0.0785 | No |
| 29 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 8963 | 0.000 | -0.0791 | No |
| 30 | CRISP2 | cysteine rich secretory protein 2 [Source:HGNC Symbol;Acc:HGNC:12024] | 9004 | 0.000 | -0.0802 | No |
| 31 | NPY5R | neuropeptide Y receptor Y5 [Source:HGNC Symbol;Acc:HGNC:7958] | 9011 | 0.000 | -0.0803 | No |
| 32 | DMRT1 | doublesex and mab-3 related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2934] | 9438 | 0.000 | -0.0918 | No |
| 33 | NEFH | neurofilament heavy [Source:HGNC Symbol;Acc:HGNC:7737] | 9553 | 0.000 | -0.0949 | No |
| 34 | GRM8 | glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600] | 9852 | 0.000 | -0.1030 | No |
| 35 | TULP2 | TUB like protein 2 [Source:HGNC Symbol;Acc:HGNC:12424] | 10030 | 0.000 | -0.1078 | No |
| 36 | CFTR | CF transmembrane conductance regulator [Source:HGNC Symbol;Acc:HGNC:1884] | 10064 | 0.000 | -0.1087 | No |
| 37 | LDHC | lactate dehydrogenase C [Source:HGNC Symbol;Acc:HGNC:6544] | 11032 | 0.000 | -0.1348 | No |
| 38 | CLGN | calmegin [Source:HGNC Symbol;Acc:HGNC:2060] | 11505 | 0.000 | -0.1476 | No |
| 39 | PRM2 | protamine 2 [Source:HGNC Symbol;Acc:HGNC:9448] | 11511 | 0.000 | -0.1477 | No |
| 40 | SEPTIN4 | septin 4 [Source:HGNC Symbol;Acc:HGNC:9165] | 11698 | 0.000 | -0.1528 | No |
| 41 | JAM3 | junctional adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:15532] | 12059 | 0.000 | -0.1625 | No |
| 42 | GAD1 | glutamate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:4092] | 12388 | 0.000 | -0.1714 | No |
| 43 | THEG | theg spermatid protein [Source:HGNC Symbol;Acc:HGNC:13706] | 12605 | 0.000 | -0.1772 | No |
| 44 | TCP11 | t-complex 11 [Source:HGNC Symbol;Acc:HGNC:11658] | 14375 | 0.000 | -0.2251 | No |
| 45 | TNP2 | transition protein 2 [Source:HGNC Symbol;Acc:HGNC:11952] | 14907 | 0.000 | -0.2395 | No |
| 46 | TNP1 | transition protein 1 [Source:HGNC Symbol;Acc:HGNC:11951] | 14909 | 0.000 | -0.2395 | No |
| 47 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15515 | 0.000 | -0.2559 | No |
| 48 | CLVS1 | clavesin 1 [Source:HGNC Symbol;Acc:HGNC:23139] | 15641 | 0.000 | -0.2593 | No |
| 49 | MTNR1A | melatonin receptor 1A [Source:HGNC Symbol;Acc:HGNC:7463] | 15727 | 0.000 | -0.2616 | No |
| 50 | DCC | DCC netrin 1 receptor [Source:HGNC Symbol;Acc:HGNC:2701] | 15923 | 0.000 | -0.2668 | No |
| 51 | ACTL7B | actin like 7B [Source:HGNC Symbol;Acc:HGNC:162] | 16004 | 0.000 | -0.2690 | No |
| 52 | GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source:HGNC Symbol;Acc:HGNC:24864] | 16408 | 0.000 | -0.2799 | No |
| 53 | AKAP4 | A-kinase anchoring protein 4 [Source:HGNC Symbol;Acc:HGNC:374] | 16565 | 0.000 | -0.2841 | No |
| 54 | DMC1 | DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] | 16838 | 0.000 | -0.2915 | No |
| 55 | TKTL1 | transketolase like 1 [Source:HGNC Symbol;Acc:HGNC:11835] | 17177 | 0.000 | -0.3006 | No |
| 56 | HBZ | hemoglobin subunit zeta [Source:HGNC Symbol;Acc:HGNC:4835] | 17224 | 0.000 | -0.3019 | No |
| 57 | SYCP1 | synaptonemal complex protein 1 [Source:HGNC Symbol;Acc:HGNC:11487] | 17822 | 0.000 | -0.3180 | No |
| 58 | DNAJB8 | DnaJ heat shock protein family (Hsp40) member B8 [Source:HGNC Symbol;Acc:HGNC:23699] | 18503 | 0.000 | -0.3364 | No |
| 59 | IL12RB2 | interleukin 12 receptor subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:5972] | 19646 | 0.000 | -0.3673 | No |
| 60 | MEP1B | meprin A subunit beta [Source:HGNC Symbol;Acc:HGNC:7020] | 20242 | 0.000 | -0.3834 | No |
| 61 | ACRV1 | acrosomal vesicle protein 1 [Source:HGNC Symbol;Acc:HGNC:127] | 20446 | 0.000 | -0.3889 | No |
| 62 | TSSK2 | testis specific serine kinase 2 [Source:HGNC Symbol;Acc:HGNC:11401] | 21617 | 0.000 | -0.4206 | No |
| 63 | SNAP91 | synaptosome associated protein 91 [Source:HGNC Symbol;Acc:HGNC:14986] | 21747 | 0.000 | -0.4241 | No |
| 64 | CST8 | cystatin 8 [Source:HGNC Symbol;Acc:HGNC:2480] | 21784 | 0.000 | -0.4251 | No |
| 65 | ODF1 | outer dense fiber of sperm tails 1 [Source:HGNC Symbol;Acc:HGNC:8113] | 23615 | 0.000 | -0.4746 | No |
| 66 | ZNRF4 | zinc and ring finger 4 [Source:HGNC Symbol;Acc:HGNC:17726] | 23657 | 0.000 | -0.4757 | No |
| 67 | DDX4 | DEAD-box helicase 4 [Source:HGNC Symbol;Acc:HGNC:18700] | 23732 | 0.000 | -0.4777 | No |
| 68 | ACE | angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707] | 24352 | 0.000 | -0.4944 | No |
| 69 | MAP7 | microtubule associated protein 7 [Source:HGNC Symbol;Acc:HGNC:6869] | 24642 | 0.000 | -0.5023 | No |
| 70 | PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor [Source:HGNC Symbol;Acc:HGNC:17301] | 25467 | 0.000 | -0.5245 | No |
| 71 | SHE | Src homology 2 domain containing E [Source:HGNC Symbol;Acc:HGNC:27004] | 25587 | 0.000 | -0.5278 | No |
| 72 | YBX2 | Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948] | 27617 | 0.000 | -0.5827 | No |
| 73 | H1-6 | H1.6 linker histone, cluster member [Source:HGNC Symbol;Acc:HGNC:4720] | 27679 | 0.000 | -0.5843 | No |
| 74 | DDX25 | DEAD-box helicase 25 [Source:HGNC Symbol;Acc:HGNC:18698] | 28048 | 0.000 | -0.5943 | No |
| 75 | SLC2A5 | solute carrier family 2 member 5 [Source:HGNC Symbol;Acc:HGNC:11010] | 28143 | 0.000 | -0.5968 | No |
| 76 | PEBP1 | phosphatidylethanolamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8630] | 28426 | -0.075 | -0.6038 | No |
| 77 | PIAS2 | protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311] | 28541 | -0.107 | -0.6061 | No |
| 78 | MAST2 | microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:19035] | 28633 | -0.138 | -0.6074 | No |
| 79 | CLPB | caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664] | 28635 | -0.139 | -0.6063 | No |
| 80 | GPR182 | G protein-coupled receptor 182 [Source:HGNC Symbol;Acc:HGNC:13708] | 28956 | -0.226 | -0.6132 | No |
| 81 | SPATA6 | spermatogenesis associated 6 [Source:HGNC Symbol;Acc:HGNC:18309] | 28961 | -0.226 | -0.6115 | No |
| 82 | BRAF | B-Raf proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1097] | 29033 | -0.240 | -0.6115 | No |
| 83 | PHKG2 | phosphorylase kinase catalytic subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:8931] | 29172 | -0.280 | -0.6129 | No |
| 84 | ALOX15 | arachidonate 15-lipoxygenase [Source:HGNC Symbol;Acc:HGNC:433] | 29358 | -0.324 | -0.6153 | No |
| 85 | TALDO1 | transaldolase 1 [Source:HGNC Symbol;Acc:HGNC:11559] | 29453 | -0.349 | -0.6151 | No |
| 86 | PGK2 | phosphoglycerate kinase 2 [Source:HGNC Symbol;Acc:HGNC:8898] | 29782 | -0.425 | -0.6205 | No |
| 87 | POMC | proopiomelanocortin [Source:HGNC Symbol;Acc:HGNC:9201] | 30442 | -0.591 | -0.6336 | Yes |
| 88 | MTOR | mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] | 30547 | -0.620 | -0.6315 | Yes |
| 89 | ARL4A | ADP ribosylation factor like GTPase 4A [Source:HGNC Symbol;Acc:HGNC:695] | 30610 | -0.638 | -0.6280 | Yes |
| 90 | CHFR | checkpoint with forkhead and ring finger domains [Source:HGNC Symbol;Acc:HGNC:20455] | 30910 | -0.714 | -0.6304 | Yes |
| 91 | PSMG1 | proteasome assembly chaperone 1 [Source:HGNC Symbol;Acc:HGNC:3043] | 30976 | -0.734 | -0.6262 | Yes |
| 92 | TUBA3C | tubulin alpha 3c [Source:HGNC Symbol;Acc:HGNC:12408] | 31315 | -0.852 | -0.6285 | Yes |
| 93 | SLC12A2 | solute carrier family 12 member 2 [Source:HGNC Symbol;Acc:HGNC:10911] | 31775 | -0.983 | -0.6330 | Yes |
| 94 | VDAC3 | voltage dependent anion channel 3 [Source:HGNC Symbol;Acc:HGNC:12674] | 31893 | -1.023 | -0.6280 | Yes |
| 95 | PHF7 | PHD finger protein 7 [Source:HGNC Symbol;Acc:HGNC:18458] | 31977 | -1.056 | -0.6217 | Yes |
| 96 | PDHA2 | pyruvate dehydrogenase E1 subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:8807] | 32035 | -1.077 | -0.6146 | Yes |
| 97 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 32153 | -1.113 | -0.6088 | Yes |
| 98 | IDE | insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381] | 32241 | -1.143 | -0.6020 | Yes |
| 99 | GSTM3 | glutathione S-transferase mu 3 [Source:HGNC Symbol;Acc:HGNC:4635] | 32383 | -1.209 | -0.5961 | Yes |
| 100 | GSG1 | germ cell associated 1 [Source:HGNC Symbol;Acc:HGNC:19716] | 32783 | -1.360 | -0.5959 | Yes |
| 101 | ZC3H14 | zinc finger CCCH-type containing 14 [Source:HGNC Symbol;Acc:HGNC:20509] | 33001 | -1.465 | -0.5900 | Yes |
| 102 | SIRT1 | sirtuin 1 [Source:HGNC Symbol;Acc:HGNC:14929] | 33002 | -1.466 | -0.5782 | Yes |
| 103 | GFI1 | growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237] | 33340 | -1.529 | -0.5751 | Yes |
| 104 | NOS1 | nitric oxide synthase 1 [Source:HGNC Symbol;Acc:HGNC:7872] | 33343 | -1.530 | -0.5628 | Yes |
| 105 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 33394 | -1.552 | -0.5517 | Yes |
| 106 | PARP2 | poly(ADP-ribose) polymerase 2 [Source:HGNC Symbol;Acc:HGNC:272] | 33412 | -1.560 | -0.5396 | Yes |
| 107 | NF2 | neurofibromin 2 [Source:HGNC Symbol;Acc:HGNC:7773] | 33631 | -1.659 | -0.5321 | Yes |
| 108 | MLLT10 | MLLT10 histone lysine methyltransferase DOT1L cofactor [Source:HGNC Symbol;Acc:HGNC:16063] | 33690 | -1.685 | -0.5202 | Yes |
| 109 | ZPBP | zona pellucida binding protein [Source:HGNC Symbol;Acc:HGNC:15662] | 33754 | -1.711 | -0.5081 | Yes |
| 110 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 33929 | -1.793 | -0.4984 | Yes |
| 111 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 34049 | -1.856 | -0.4867 | Yes |
| 112 | HSPA2 | heat shock protein family A (Hsp70) member 2 [Source:HGNC Symbol;Acc:HGNC:5235] | 34348 | -2.016 | -0.4785 | Yes |
| 113 | IFT88 | intraflagellar transport 88 [Source:HGNC Symbol;Acc:HGNC:20606] | 34557 | -2.126 | -0.4671 | Yes |
| 114 | HSPA4L | heat shock protein family A (Hsp70) member 4 like [Source:HGNC Symbol;Acc:HGNC:17041] | 34611 | -2.151 | -0.4512 | Yes |
| 115 | MLF1 | myeloid leukemia factor 1 [Source:HGNC Symbol;Acc:HGNC:7125] | 34618 | -2.156 | -0.4340 | Yes |
| 116 | ACRBP | acrosin binding protein [Source:HGNC Symbol;Acc:HGNC:17195] | 34734 | -2.244 | -0.4191 | Yes |
| 117 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 34864 | -2.323 | -0.4039 | Yes |
| 118 | PACRG | parkin coregulated [Source:HGNC Symbol;Acc:HGNC:19152] | 35117 | -2.434 | -0.3912 | Yes |
| 119 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 35122 | -2.440 | -0.3716 | Yes |
| 120 | NPHP1 | nephrocystin 1 [Source:HGNC Symbol;Acc:HGNC:7905] | 35176 | -2.492 | -0.3530 | Yes |
| 121 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 35217 | -2.531 | -0.3338 | Yes |
| 122 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] | 35359 | -2.639 | -0.3164 | Yes |
| 123 | STRBP | spermatid perinuclear RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16462] | 35489 | -2.734 | -0.2979 | Yes |
| 124 | NCAPH | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] | 35559 | -2.806 | -0.2772 | Yes |
| 125 | GMCL1 | germ cell-less 1, spermatogenesis associated [Source:HGNC Symbol;Acc:HGNC:23843] | 35614 | -2.865 | -0.2556 | Yes |
| 126 | TOPBP1 | DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008] | 35856 | -3.032 | -0.2377 | Yes |
| 127 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 36104 | -3.290 | -0.2179 | Yes |
| 128 | TNNI3 | troponin I3, cardiac type [Source:HGNC Symbol;Acc:HGNC:11947] | 36130 | -3.329 | -0.1918 | Yes |
| 129 | PCSK4 | proprotein convertase subtilisin/kexin type 4 [Source:HGNC Symbol;Acc:HGNC:8746] | 36281 | -3.491 | -0.1678 | Yes |
| 130 | RPL39L | ribosomal protein L39 like [Source:HGNC Symbol;Acc:HGNC:17094] | 36301 | -3.495 | -0.1402 | Yes |
| 131 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 36332 | -3.523 | -0.1127 | Yes |
| 132 | NEK2 | NIMA related kinase 2 [Source:HGNC Symbol;Acc:HGNC:7745] | 36597 | -3.856 | -0.0889 | Yes |
| 133 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 36610 | -3.875 | -0.0580 | Yes |
| 134 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36761 | -4.065 | -0.0294 | Yes |
| 135 | LPIN1 | lipin 1 [Source:HGNC Symbol;Acc:HGNC:13345] | 37037 | -4.756 | 0.0014 | Yes |
