Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_LPS_versus_WT_NA.Nof1.cls #WT_LPS_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_LPS_versus_WT_NA_repos |
| Upregulated in class | WT_LPS |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.4816638 |
| Normalized Enrichment Score (NES) | 1.2279997 |
| Nominal p-value | 0.016949153 |
| FDR q-value | 0.10825491 |
| FWER p-Value | 0.308 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 51 | 4.875 | 0.0419 | Yes |
| 2 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 533 | 3.106 | 0.0564 | Yes |
| 3 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 618 | 2.964 | 0.0804 | Yes |
| 4 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 684 | 2.833 | 0.1038 | Yes |
| 5 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 884 | 2.537 | 0.1209 | Yes |
| 6 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 973 | 2.393 | 0.1397 | Yes |
| 7 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 1012 | 2.316 | 0.1593 | Yes |
| 8 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 1089 | 2.212 | 0.1768 | Yes |
| 9 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 1297 | 1.962 | 0.1886 | Yes |
| 10 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1320 | 1.929 | 0.2051 | Yes |
| 11 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 1406 | 1.832 | 0.2191 | Yes |
| 12 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 1610 | 1.746 | 0.2291 | Yes |
| 13 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 1625 | 1.732 | 0.2441 | Yes |
| 14 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 1636 | 1.719 | 0.2591 | Yes |
| 15 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 1671 | 1.667 | 0.2729 | Yes |
| 16 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 1722 | 1.629 | 0.2860 | Yes |
| 17 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1774 | 1.592 | 0.2988 | Yes |
| 18 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 1986 | 1.438 | 0.3058 | Yes |
| 19 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 2033 | 1.402 | 0.3170 | Yes |
| 20 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 2116 | 1.350 | 0.3268 | Yes |
| 21 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2152 | 1.327 | 0.3376 | Yes |
| 22 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 2306 | 1.236 | 0.3444 | Yes |
| 23 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 2401 | 1.176 | 0.3523 | Yes |
| 24 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 2655 | 1.058 | 0.3548 | Yes |
| 25 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 2665 | 1.053 | 0.3639 | Yes |
| 26 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 2717 | 1.026 | 0.3716 | Yes |
| 27 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 2723 | 1.020 | 0.3805 | Yes |
| 28 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 2753 | 1.009 | 0.3887 | Yes |
| 29 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 2785 | 0.992 | 0.3967 | Yes |
| 30 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 2868 | 0.959 | 0.4030 | Yes |
| 31 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 2908 | 0.938 | 0.4102 | Yes |
| 32 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 2920 | 0.933 | 0.4182 | Yes |
| 33 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 3063 | 0.866 | 0.4221 | Yes |
| 34 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 3242 | 0.807 | 0.4244 | Yes |
| 35 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 3271 | 0.794 | 0.4307 | Yes |
| 36 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 3290 | 0.785 | 0.4372 | Yes |
| 37 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 3322 | 0.775 | 0.4432 | Yes |
| 38 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 3602 | 0.670 | 0.4416 | Yes |
| 39 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 3848 | 0.582 | 0.4401 | Yes |
| 40 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 3861 | 0.579 | 0.4449 | Yes |
| 41 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 3927 | 0.561 | 0.4481 | Yes |
| 42 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 4014 | 0.534 | 0.4506 | Yes |
| 43 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 4067 | 0.513 | 0.4537 | Yes |
| 44 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 4084 | 0.507 | 0.4578 | Yes |
| 45 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 4190 | 0.472 | 0.4591 | Yes |
| 46 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 4262 | 0.443 | 0.4611 | Yes |
| 47 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 4274 | 0.440 | 0.4647 | Yes |
| 48 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 4351 | 0.411 | 0.4663 | Yes |
| 49 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 4352 | 0.410 | 0.4700 | Yes |
| 50 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 4494 | 0.369 | 0.4694 | Yes |
| 51 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 4518 | 0.361 | 0.4720 | Yes |
| 52 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 4522 | 0.360 | 0.4751 | Yes |
| 53 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 4523 | 0.359 | 0.4783 | Yes |
| 54 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 4533 | 0.356 | 0.4812 | Yes |
| 55 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 4692 | 0.315 | 0.4797 | Yes |
| 56 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 4752 | 0.299 | 0.4808 | Yes |
| 57 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 4813 | 0.282 | 0.4817 | Yes |
| 58 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 4987 | 0.234 | 0.4791 | No |
| 59 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 5054 | 0.214 | 0.4792 | No |
| 60 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 5065 | 0.209 | 0.4808 | No |
| 61 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 5135 | 0.192 | 0.4806 | No |
| 62 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 5203 | 0.171 | 0.4803 | No |
| 63 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 5210 | 0.169 | 0.4816 | No |
| 64 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 5666 | 0.149 | 0.4706 | No |
| 65 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 5851 | 0.088 | 0.4664 | No |
| 66 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 5862 | 0.084 | 0.4669 | No |
| 67 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 5877 | 0.081 | 0.4673 | No |
| 68 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 5883 | 0.078 | 0.4678 | No |
| 69 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 5902 | 0.073 | 0.4680 | No |
| 70 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 5927 | 0.064 | 0.4679 | No |
| 71 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 5986 | 0.044 | 0.4667 | No |
| 72 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 6019 | 0.034 | 0.4662 | No |
| 73 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 6023 | 0.033 | 0.4664 | No |
| 74 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11720 | 0.000 | 0.3123 | No |
| 75 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 27840 | 0.000 | -0.1236 | No |
| 76 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 28217 | -0.013 | -0.1336 | No |
| 77 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28520 | -0.100 | -0.1409 | No |
| 78 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 28577 | -0.120 | -0.1414 | No |
| 79 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28669 | -0.144 | -0.1425 | No |
| 80 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 28681 | -0.147 | -0.1415 | No |
| 81 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28750 | -0.168 | -0.1419 | No |
| 82 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 28824 | -0.186 | -0.1422 | No |
| 83 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 28894 | -0.208 | -0.1422 | No |
| 84 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 29458 | -0.350 | -0.1544 | No |
| 85 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 29486 | -0.359 | -0.1519 | No |
| 86 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 29525 | -0.370 | -0.1497 | No |
| 87 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 29537 | -0.371 | -0.1467 | No |
| 88 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 29574 | -0.379 | -0.1443 | No |
| 89 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29633 | -0.398 | -0.1423 | No |
| 90 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 29920 | -0.460 | -0.1460 | No |
| 91 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 29936 | -0.464 | -0.1423 | No |
| 92 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 30532 | -0.615 | -0.1529 | No |
| 93 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 30866 | -0.698 | -0.1557 | No |
| 94 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 30989 | -0.740 | -0.1524 | No |
| 95 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 31031 | -0.755 | -0.1468 | No |
| 96 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 31195 | -0.813 | -0.1440 | No |
| 97 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 31271 | -0.838 | -0.1386 | No |
| 98 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 31587 | -0.922 | -0.1390 | No |
| 99 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 31690 | -0.960 | -0.1332 | No |
| 100 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 32040 | -1.079 | -0.1331 | No |
| 101 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 32865 | -1.409 | -0.1429 | No |
| 102 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 33487 | -1.596 | -0.1455 | No |
| 103 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 33518 | -1.608 | -0.1321 | No |
| 104 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 33815 | -1.739 | -0.1246 | No |
| 105 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 33975 | -1.818 | -0.1128 | No |
| 106 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 34157 | -1.908 | -0.1008 | No |
| 107 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 34651 | -2.179 | -0.0948 | No |
| 108 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 34719 | -2.231 | -0.0768 | No |
| 109 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 35276 | -2.572 | -0.0690 | No |
| 110 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 35376 | -2.655 | -0.0482 | No |
| 111 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35379 | -2.657 | -0.0247 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36567 | -3.812 | -0.0230 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 36828 | -4.180 | 0.0071 | No |
