Datasetgreenberg_collapsed_to_symbols.Nof1.cls
#WT_GAQ_versus_WT_NA.Nof1.cls
#WT_GAQ_versus_WT_NA_repos
PhenotypeNof1.cls#WT_GAQ_versus_WT_NA_repos
Upregulated in classWT_GAQ
GeneSetBMI1_DN_MEL18_DN.V1_UP
Enrichment Score (ES)0.5394808
Normalized Enrichment Score (NES)1.4459984
Nominal p-value0.0
FDR q-value0.06603635
FWER p-Value0.157
Table: GSEA Results Summary



Fig 1: Enrichment plot: BMI1_DN_MEL18_DN.V1_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PMEPA1prostate transmembrane protein, androgen induced 1 [Source:HGNC Symbol;Acc:HGNC:14107]84.8530.0328Yes
2IL1Ainterleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991]104.8340.0657Yes
3FOSL1FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718]134.7950.0983Yes
4EDN1endothelin 1 [Source:HGNC Symbol;Acc:HGNC:3176]474.2370.1263Yes
5GADD45Agrowth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095]574.1230.1541Yes
6SLC7A11solute carrier family 7 member 11 [Source:HGNC Symbol;Acc:HGNC:11059]614.0570.1817Yes
7C3AR1complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319]624.0470.2093Yes
8ZC3H12Azinc finger CCCH-type containing 12A [Source:HGNC Symbol;Acc:HGNC:26259]723.9130.2357Yes
9ITGA5integrin subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:6141]813.8040.2614Yes
10VEGFCvascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682]983.7080.2862Yes
11PIM1Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986]1363.4360.3086Yes
12EHD1EH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:3242]1683.2640.3300Yes
13ABCA1ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29]1773.2200.3517Yes
14LIFLIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596]1933.1440.3727Yes
15CHST11carbohydrate sulfotransferase 11 [Source:HGNC Symbol;Acc:HGNC:17422]2482.8640.3908Yes
16CDC42EP2CDC42 effector protein 2 [Source:HGNC Symbol;Acc:HGNC:16263]3132.6360.4070Yes
17TNIP3TNFAIP3 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:19315]4012.4100.4211Yes
18CRISPLD2cysteine rich secretory protein LCCL domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25248]4072.4010.4373Yes
19PIEZO1piezo type mechanosensitive ion channel component 1 [Source:HGNC Symbol;Acc:HGNC:28993]4372.3160.4523Yes
20ATF3activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785]7041.8530.4577Yes
21GFPT2glutamine-fructose-6-phosphate transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4242]7111.8460.4701Yes
22TNFAIP6TNF alpha induced protein 6 [Source:HGNC Symbol;Acc:HGNC:11898]8031.7350.4795Yes
23NRP2neuropilin 2 [Source:HGNC Symbol;Acc:HGNC:8005]9641.5620.4858Yes
24RUSC2RUN and SH3 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23625]10591.4760.4933Yes
25KCNN4potassium calcium-activated channel subfamily N member 4 [Source:HGNC Symbol;Acc:HGNC:6293]10911.4580.5024Yes
26LCP1lymphocyte cytosolic protein 1 [Source:HGNC Symbol;Acc:HGNC:6528]12041.3770.5087Yes
27NKAIN1sodium/potassium transporting ATPase interacting 1 [Source:HGNC Symbol;Acc:HGNC:25743]14661.2010.5098Yes
28FAPfibroblast activation protein alpha [Source:HGNC Symbol;Acc:HGNC:3590]14851.1890.5174Yes
29SLC7A5solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063]15371.1610.5240Yes
30DUSP10dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065]15531.1530.5314Yes
31KLF7Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350]16371.1120.5368Yes
32APBB2amyloid beta precursor protein binding family B member 2 [Source:HGNC Symbol;Acc:HGNC:582]18391.0190.5383Yes
33SLC1A4solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942]22080.8750.5343Yes
34HBEGFheparin binding EGF like growth factor [Source:HGNC Symbol;Acc:HGNC:3059]23260.8330.5368Yes
35CSF1colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432]25480.7630.5360Yes
36FJX1four-jointed box kinase 1 [Source:HGNC Symbol;Acc:HGNC:17166]27360.7150.5358Yes
37ZEB2zinc finger E-box binding homeobox 2 [Source:HGNC Symbol;Acc:HGNC:14881]27780.7050.5395Yes
38TUFT1tuftelin 1 [Source:HGNC Symbol;Acc:HGNC:12422]29580.6520.5391No
39ZNF639zinc finger protein 639 [Source:HGNC Symbol;Acc:HGNC:30950]32920.5650.5339No
40TFECtranscription factor EC [Source:HGNC Symbol;Acc:HGNC:11754]34670.5260.5328No
41MT1Fmetallothionein 1F [Source:HGNC Symbol;Acc:HGNC:7398]37150.4750.5293No
42RREB1ras responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10449]38350.4510.5292No
43ASPHaspartate beta-hydroxylase [Source:HGNC Symbol;Acc:HGNC:757]39130.4370.5301No
44BST1bone marrow stromal cell antigen 1 [Source:HGNC Symbol;Acc:HGNC:1118]41390.3970.5267No
45MICALL1MICAL like 1 [Source:HGNC Symbol;Acc:HGNC:29804]41590.3940.5289No
46TRIB3tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228]43130.3650.5272No
47C2CD2C2 calcium dependent domain containing 2 [Source:HGNC Symbol;Acc:HGNC:1266]45840.3170.5221No
48MAP3K7CLMAP3K7 C-terminal like [Source:HGNC Symbol;Acc:HGNC:16457]46190.3090.5232No
49PODXLpodocalyxin like [Source:HGNC Symbol;Acc:HGNC:9171]46590.3000.5242No
50SIK1salt inducible kinase 1 [Source:HGNC Symbol;Acc:HGNC:11142]52110.2090.5107No
51SLC19A1solute carrier family 19 member 1 [Source:HGNC Symbol;Acc:HGNC:10937]52220.2070.5119No
52KRT75keratin 75 [Source:HGNC Symbol;Acc:HGNC:24431]52700.2000.5120No
53TGFB2transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768]54020.1770.5096No
54TNFRSF8TNF receptor superfamily member 8 [Source:HGNC Symbol;Acc:HGNC:11923]55520.1490.5066No
55PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:8978]57680.1130.5016No
56GAB2GRB2 associated binding protein 2 [Source:HGNC Symbol;Acc:HGNC:14458]59480.0940.4973No
57INHBAinhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066]59650.0910.4975No
58ARL4AADP ribosylation factor like GTPase 4A [Source:HGNC Symbol;Acc:HGNC:695]61890.0580.4919No
59STX1Asyntaxin 1A [Source:HGNC Symbol;Acc:HGNC:11433]62500.0490.4906No
60FGF21fibroblast growth factor 21 [Source:HGNC Symbol;Acc:HGNC:3678]71150.0000.4672No
61ABLIM3actin binding LIM protein family member 3 [Source:HGNC Symbol;Acc:HGNC:29132]72570.0000.4634No
62GREM1gremlin 1, DAN family BMP antagonist [Source:HGNC Symbol;Acc:HGNC:2001]84410.0000.4314No
63TNFSF9TNF superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939]90570.0000.4147No
64VLDLRvery low density lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:12698]97340.0000.3964No
65TNFRSF9TNF receptor superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11924]99930.0000.3895No
66PLATplasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051]101110.0000.3863No
67ADAM19ADAM metallopeptidase domain 19 [Source:HGNC Symbol;Acc:HGNC:197]101220.0000.3860No
68ADAM12ADAM metallopeptidase domain 12 [Source:HGNC Symbol;Acc:HGNC:190]101240.0000.3860No
69ADM2adrenomedullin 2 [Source:HGNC Symbol;Acc:HGNC:28898]113230.0000.3536No
70LRRC15leucine rich repeat containing 15 [Source:HGNC Symbol;Acc:HGNC:20818]115830.0000.3466No
71PTHLHparathyroid hormone like hormone [Source:HGNC Symbol;Acc:HGNC:9607]118160.0000.3403No
72VNN1vanin 1 [Source:HGNC Symbol;Acc:HGNC:12705]128830.0000.3114No
73TACR3tachykinin receptor 3 [Source:HGNC Symbol;Acc:HGNC:11528]133460.0000.2989No
74GDF5growth differentiation factor 5 [Source:HGNC Symbol;Acc:HGNC:4220]135540.0000.2933No
75TAGLNtransgelin [Source:HGNC Symbol;Acc:HGNC:11553]139390.0000.2829No
76COL13A1collagen type XIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2190]156310.0000.2372No
77HTR1D5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289]156890.0000.2356No
78F3coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541]162410.0000.2207No
79COL16A1collagen type XVI alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2193]165580.0000.2122No
80GALgalanin and GMAP prepropeptide [Source:HGNC Symbol;Acc:HGNC:4114]169660.0000.2011No
81TIMP3TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822]172040.0000.1947No
82MGLLmonoglyceride lipase [Source:HGNC Symbol;Acc:HGNC:17038]172160.0000.1944No
83FAM189A1family with sequence similarity 189 member A1 [Source:HGNC Symbol;Acc:HGNC:29075]173760.0000.1901No
84HAPLN1hyaluronan and proteoglycan link protein 1 [Source:HGNC Symbol;Acc:HGNC:2380]174710.0000.1876No
85MICAMHC class I polypeptide-related sequence A [Source:HGNC Symbol;Acc:HGNC:7090]177320.0000.1805No
86PAPPApappalysin 1 [Source:HGNC Symbol;Acc:HGNC:8602]179230.0000.1754No
87CDH13cadherin 13 [Source:HGNC Symbol;Acc:HGNC:1753]187600.0000.1528No
88BMP5bone morphogenetic protein 5 [Source:HGNC Symbol;Acc:HGNC:1072]191030.0000.1435No
89MMP7matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174]191300.0000.1428No
90CXCL8C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025]194790.0000.1334No
91CXCL1C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602]194880.0000.1332No
92ARNTL2aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol;Acc:HGNC:18984]198000.0000.1248No
93TCIMtranscriptional and immune response regulator [Source:HGNC Symbol;Acc:HGNC:1357]198830.0000.1225No
94SCML2Scm polycomb group protein like 2 [Source:HGNC Symbol;Acc:HGNC:10581]203440.0000.1101No
95CPA4carboxypeptidase A4 [Source:HGNC Symbol;Acc:HGNC:15740]236930.0000.0195No
96NPPBnatriuretic peptide B [Source:HGNC Symbol;Acc:HGNC:7940]238660.0000.0148No
97LAMB3laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490]239240.0000.0133No
98CSF2colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434]247000.000-0.0077No
99LSAMPlimbic system associated membrane protein [Source:HGNC Symbol;Acc:HGNC:6705]249160.000-0.0135No
100WNT5BWnt family member 5B [Source:HGNC Symbol;Acc:HGNC:16265]249390.000-0.0141No
101CLDN1claudin 1 [Source:HGNC Symbol;Acc:HGNC:2032]250450.000-0.0170No
102HAS2hyaluronan synthase 2 [Source:HGNC Symbol;Acc:HGNC:4819]251100.000-0.0187No
103PDCD1LG2programmed cell death 1 ligand 2 [Source:HGNC Symbol;Acc:HGNC:18731]257950.000-0.0372No
104PLAURplasminogen activator, urokinase receptor [Source:HGNC Symbol;Acc:HGNC:9053]258930.000-0.0398No
105ITGB8integrin subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:6163]266490.000-0.0603No
106ITGB6integrin subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:6161]266520.000-0.0603No
107ITGA3integrin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6139]266550.000-0.0604No
108PAGE1PAGE family member 1 [Source:HGNC Symbol;Acc:HGNC:4107]267440.000-0.0628No
109BIRC3baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591]27956-0.045-0.0952No
110IL7Rinterleukin 7 receptor [Source:HGNC Symbol;Acc:HGNC:6024]27994-0.049-0.0959No
111SLC22A4solute carrier family 22 member 4 [Source:HGNC Symbol;Acc:HGNC:10968]28674-0.146-0.1133No
112NT5E5'-nucleotidase ecto [Source:HGNC Symbol;Acc:HGNC:8021]28926-0.179-0.1188No
113ANXA3annexin A3 [Source:HGNC Symbol;Acc:HGNC:541]29116-0.200-0.1226No
114KCNN3potassium calcium-activated channel subfamily N member 3 [Source:HGNC Symbol;Acc:HGNC:6292]29407-0.237-0.1288No
115TEKTEK receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11724]29507-0.250-0.1298No
116VEGFAvascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680]29736-0.285-0.1340No
117ADGRE5adhesion G protein-coupled receptor E5 [Source:HGNC Symbol;Acc:HGNC:1711]30527-0.405-0.1527No
118PSAT1phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129]30760-0.442-0.1559No
119STC2stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374]30967-0.474-0.1583No
120CCND1cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582]31124-0.500-0.1591No
121KMT2Alysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]31625-0.592-0.1686No
122CSPG4chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:2466]32118-0.692-0.1772No
123TRIOtrio Rho guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:12303]32667-0.815-0.1865No
124ADGBandroglobin [Source:HGNC Symbol;Acc:HGNC:21212]32705-0.825-0.1819No
125SLC6A9solute carrier family 6 member 9 [Source:HGNC Symbol;Acc:HGNC:11056]33268-0.967-0.1905No
126COL7A1collagen type VII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2214]33283-0.971-0.1843No
127INHBEinhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029]33702-1.093-0.1881No
128C2CD2LC2CD2 like [Source:HGNC Symbol;Acc:HGNC:29000]34508-1.384-0.2005No
129FADS3fatty acid desaturase 3 [Source:HGNC Symbol;Acc:HGNC:3576]34642-1.449-0.1942No
130ADMadrenomedullin [Source:HGNC Symbol;Acc:HGNC:259]34809-1.529-0.1883No
131KIF21Bkinesin family member 21B [Source:HGNC Symbol;Acc:HGNC:29442]34985-1.604-0.1821No
132P2RX5purinergic receptor P2X 5 [Source:HGNC Symbol;Acc:HGNC:8536]35020-1.626-0.1720No
133LHFPL2LHFPL tetraspan subfamily member 2 [Source:HGNC Symbol;Acc:HGNC:6588]35250-1.758-0.1662No
134JAG1jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188]35309-1.796-0.1555No
135CHST3carbohydrate sulfotransferase 3 [Source:HGNC Symbol;Acc:HGNC:1971]35686-2.045-0.1518No
136TMEM51transmembrane protein 51 [Source:HGNC Symbol;Acc:HGNC:25488]36019-2.311-0.1450No
137NAV2neuron navigator 2 [Source:HGNC Symbol;Acc:HGNC:15997]36189-2.469-0.1328No
138OGFRL1opioid growth factor receptor like 1 [Source:HGNC Symbol;Acc:HGNC:21378]36206-2.483-0.1163No
139ARL4CADP ribosylation factor like GTPase 4C [Source:HGNC Symbol;Acc:HGNC:698]36325-2.617-0.1017No
140PLEKHO1pleckstrin homology domain containing O1 [Source:HGNC Symbol;Acc:HGNC:24310]36622-3.032-0.0890No
141WEE1WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761]36752-3.297-0.0700No
142ATP13A2ATPase cation transporting 13A2 [Source:HGNC Symbol;Acc:HGNC:30213]36826-3.460-0.0485No
143ITGA4integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140]36992-4.041-0.0254No
144ADRB2adrenoceptor beta 2 [Source:HGNC Symbol;Acc:HGNC:286]37005-4.1140.0023No
Table: GSEA details [plain text format]



Fig 2: BMI1_DN_MEL18_DN.V1_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BMI1_DN_MEL18_DN.V1_UP: Random ES distribution   
Gene set null distribution of ES for BMI1_DN_MEL18_DN.V1_UP