Datasetgreenberg_collapsed_to_symbols.Nof1.cls
#WT_GAQ_versus_WT_NA.Nof1.cls
#WT_GAQ_versus_WT_NA_repos
PhenotypeNof1.cls#WT_GAQ_versus_WT_NA_repos
Upregulated in classWT_GAQ
GeneSetKRAS.LUNG_UP.V1_UP
Enrichment Score (ES)0.46014932
Normalized Enrichment Score (NES)1.2136217
Nominal p-value0.03937008
FDR q-value0.17437458
FWER p-Value0.687
Table: GSEA Results Summary



Fig 1: Enrichment plot: KRAS.LUNG_UP.V1_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CSF3colony stimulating factor 3 [Source:HGNC Symbol;Acc:HGNC:2438]114.8220.0563Yes
2BCL2A1BCL2 related protein A1 [Source:HGNC Symbol;Acc:HGNC:991]434.2930.1059Yes
3IL1RL1interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998]454.2490.1558Yes
4C3AR1complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319]624.0470.2030Yes
5ETS1ETS proto-oncogene 1, transcription factor [Source:HGNC Symbol;Acc:HGNC:3488]893.7380.2462Yes
6IL13RA2interleukin 13 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:5975]2212.9900.2778Yes
7TNNT2troponin T2, cardiac type [Source:HGNC Symbol;Acc:HGNC:11949]2242.9800.3127Yes
8DCBLD2discoidin, CUB and LCCL domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24627]2892.7260.3430Yes
9DOCK4dedicator of cytokinesis 4 [Source:HGNC Symbol;Acc:HGNC:19192]4352.3180.3663Yes
10POLMDNA polymerase mu [Source:HGNC Symbol;Acc:HGNC:9185]4652.2490.3919Yes
11SLC6A4solute carrier family 6 member 4 [Source:HGNC Symbol;Acc:HGNC:11050]4662.2460.4183Yes
12PRKG2protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416]7741.7740.4309Yes
13IKZF1IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176]8881.6370.4470Yes
14ADAM8ADAM metallopeptidase domain 8 [Source:HGNC Symbol;Acc:HGNC:215]10501.4860.4601Yes
15NESnestin [Source:HGNC Symbol;Acc:HGNC:7756]20920.9160.4427No
16HBEGFheparin binding EGF like growth factor [Source:HGNC Symbol;Acc:HGNC:3059]23260.8330.4462No
17ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:18080]24560.7920.4520No
18EVI2Aecotropic viral integration site 2A [Source:HGNC Symbol;Acc:HGNC:3499]26090.7450.4567No
19ZNF639zinc finger protein 639 [Source:HGNC Symbol;Acc:HGNC:30950]32920.5650.4449No
20MYH2myosin heavy chain 2 [Source:HGNC Symbol;Acc:HGNC:7572]36360.4900.4413No
21ZBTB48zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930]37680.4640.4432No
22SLC18A1solute carrier family 18 member A1 [Source:HGNC Symbol;Acc:HGNC:10934]38150.4550.4473No
23RREB1ras responsive element binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10449]38350.4510.4521No
24SH2D2ASH2 domain containing 2A [Source:HGNC Symbol;Acc:HGNC:10821]42340.3810.4458No
25FBXO4F-box protein 4 [Source:HGNC Symbol;Acc:HGNC:13583]43170.3630.4479No
26ASGR2asialoglycoprotein receptor 2 [Source:HGNC Symbol;Acc:HGNC:743]47830.2780.4386No
27CFAP69cilia and flagella associated protein 69 [Source:HGNC Symbol;Acc:HGNC:26107]49420.2510.4372No
28LRIG1leucine rich repeats and immunoglobulin like domains 1 [Source:HGNC Symbol;Acc:HGNC:17360]55420.1500.4228No
29HS3ST3A1heparan sulfate-glucosamine 3-sulfotransferase 3A1 [Source:HGNC Symbol;Acc:HGNC:5196]55740.1460.4236No
30CYP4F8cytochrome P450 family 4 subfamily F member 8 [Source:HGNC Symbol;Acc:HGNC:2648]58010.1090.4188No
31INHBAinhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066]59650.0910.4155No
32EGFL7EGF like domain multiple 7 [Source:HGNC Symbol;Acc:HGNC:20594]59660.0910.4165No
33WNT7AWnt family member 7A [Source:HGNC Symbol;Acc:HGNC:12786]60870.0720.4141No
34NAV3neuron navigator 3 [Source:HGNC Symbol;Acc:HGNC:15998]62520.0470.4103No
35CCL20C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619]66090.0000.4006No
36SCG5secretogranin V [Source:HGNC Symbol;Acc:HGNC:10816]67520.0000.3968No
37CRYAAcrystallin alpha A [Source:HGNC Symbol;Acc:HGNC:2388]68780.0000.3934No
38RNASE1ribonuclease A family member 1, pancreatic [Source:HGNC Symbol;Acc:HGNC:10044]74540.0000.3778No
39SLCO5A1solute carrier organic anion transporter family member 5A1 [Source:HGNC Symbol;Acc:HGNC:19046]74740.0000.3773No
40CD247CD247 molecule [Source:HGNC Symbol;Acc:HGNC:1677]83230.0000.3544No
41FRMD1FERM domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21240]87430.0000.3430No
42CLEC4AC-type lectin domain family 4 member A [Source:HGNC Symbol;Acc:HGNC:13257]96550.0000.3184No
43NDNFneuron derived neurotrophic factor [Source:HGNC Symbol;Acc:HGNC:26256]96870.0000.3175No
44KCNA5potassium voltage-gated channel subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:6224]99080.0000.3116No
45GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A [Source:HGNC Symbol;Acc:HGNC:4585]105160.0000.2952No
46ADA2adenosine deaminase 2 [Source:HGNC Symbol;Acc:HGNC:1839]112380.0000.2757No
47CCT8L2chaperonin containing TCP1 subunit 8 like 2 [Source:HGNC Symbol;Acc:HGNC:15553]113260.0000.2733No
48N4BP2L2-IT2N4BPL2 intronic transcript 2 [Source:HGNC Symbol;Acc:HGNC:25038]116020.0000.2659No
49TSPAN1tetraspanin 1 [Source:HGNC Symbol;Acc:HGNC:20657]116960.0000.2633No
50PRG3proteoglycan 3, pro eosinophil major basic protein 2 [Source:HGNC Symbol;Acc:HGNC:9363]117020.0000.2632No
51NPHS1NPHS1 adhesion molecule, nephrin [Source:HGNC Symbol;Acc:HGNC:7908]118340.0000.2597No
52SLC6A11solute carrier family 6 member 11 [Source:HGNC Symbol;Acc:HGNC:11044]120130.0000.2548No
53SIGLEC15sialic acid binding Ig like lectin 15 [Source:HGNC Symbol;Acc:HGNC:27596]120400.0000.2541No
54GBA3glucosylceramidase beta 3 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:19069]128510.0000.2322No
55RBP4retinol binding protein 4 [Source:HGNC Symbol;Acc:HGNC:9922]129950.0000.2283No
56PPP1R14Dprotein phosphatase 1 regulatory inhibitor subunit 14D [Source:HGNC Symbol;Acc:HGNC:14953]132130.0000.2225No
57HOXD11homeobox D11 [Source:HGNC Symbol;Acc:HGNC:5134]133620.0000.2185No
58LILRB1leukocyte immunoglobulin like receptor B1 [Source:HGNC Symbol;Acc:HGNC:6605]135790.0000.2126No
59OR2B6olfactory receptor family 2 subfamily B member 6 [Source:HGNC Symbol;Acc:HGNC:8241]136150.0000.2117No
60KIAA1549LKIAA1549 like [Source:HGNC Symbol;Acc:HGNC:24836]138280.0000.2059No
61RELNreelin [Source:HGNC Symbol;Acc:HGNC:9957]139540.0000.2026No
62RETNresistin [Source:HGNC Symbol;Acc:HGNC:20389]140660.0000.1996No
63HSD11B1hydroxysteroid 11-beta dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:5208]145200.0000.1873No
64PCDH17protocadherin 17 [Source:HGNC Symbol;Acc:HGNC:14267]147410.0000.1813No
65RGS4regulator of G protein signaling 4 [Source:HGNC Symbol;Acc:HGNC:10000]148570.0000.1782No
66PAX4paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618]149430.0000.1759No
67HTR75-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302]156230.0000.1575No
68BTCbetacellulin [Source:HGNC Symbol;Acc:HGNC:1121]157420.0000.1544No
69G0S2G0/G1 switch 2 [Source:HGNC Symbol;Acc:HGNC:30229]159100.0000.1498No
70IL23Ainterleukin 23 subunit alpha [Source:HGNC Symbol;Acc:HGNC:15488]159890.0000.1477No
71FUT5fucosyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:4016]177610.0000.0998No
72TAS2R1taste 2 receptor member 1 [Source:HGNC Symbol;Acc:HGNC:14909]180130.0000.0930No
73SEMG2semenogelin 2 [Source:HGNC Symbol;Acc:HGNC:10743]183470.0000.0840No
74MT3metallothionein 3 [Source:HGNC Symbol;Acc:HGNC:7408]191000.0000.0636No
75MMP1matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155]191330.0000.0628No
76NKX2-5NK2 homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2488]192310.0000.0601No
77NGFnerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808]193100.0000.0580No
78MIR124-1HGMIR124-1 host gene [Source:HGNC Symbol;Acc:HGNC:27231]194690.0000.0538No
79CXCL8C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025]194790.0000.0535No
80CXCL5C-X-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10642]194900.0000.0532No
81TBX3T-box transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11602]197520.0000.0462No
82ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 [Source:HGNC Symbol;Acc:HGNC:219]200510.0000.0381No
83IGSF1immunoglobulin superfamily member 1 [Source:HGNC Symbol;Acc:HGNC:5948]206950.0000.0207No
84MMP20matrix metallopeptidase 20 [Source:HGNC Symbol;Acc:HGNC:7167]209110.0000.0149No
85ZNF749zinc finger protein 749 [Source:HGNC Symbol;Acc:HGNC:32783]211010.0000.0098No
86SLC16A8solute carrier family 16 member 8 [Source:HGNC Symbol;Acc:HGNC:16270]214750.000-0.0003No
87KIR2DL3killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 [Source:HGNC Symbol;Acc:HGNC:6331]217110.000-0.0067No
88CYP2J2cytochrome P450 family 2 subfamily J member 2 [Source:HGNC Symbol;Acc:HGNC:2634]228250.000-0.0368No
89CD1ACD1a molecule [Source:HGNC Symbol;Acc:HGNC:1634]231020.000-0.0443No
90CD48CD48 molecule [Source:HGNC Symbol;Acc:HGNC:1683]231650.000-0.0459No
91CD80CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700]232260.000-0.0476No
92DEFA5defensin alpha 5 [Source:HGNC Symbol;Acc:HGNC:2764]237100.000-0.0606No
93NELL2neural EGFL like 2 [Source:HGNC Symbol;Acc:HGNC:7751]237840.000-0.0626No
94TSPY1testis specific protein Y-linked 1 [Source:HGNC Symbol;Acc:HGNC:12381]239650.000-0.0675No
95ADCYAP1R1ADCYAP receptor type I [Source:HGNC Symbol;Acc:HGNC:242]244420.000-0.0804No
96ALLCallantoicase [Source:HGNC Symbol;Acc:HGNC:17377]244930.000-0.0817No
97IFNA8interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429]248830.000-0.0922No
98PTPRRprotein tyrosine phosphatase receptor type R [Source:HGNC Symbol;Acc:HGNC:9680]252440.000-0.1020No
99ANO1anoctamin 1 [Source:HGNC Symbol;Acc:HGNC:21625]252710.000-0.1027No
100TEX13Atestis expressed 13A [Source:HGNC Symbol;Acc:HGNC:11735]253430.000-0.1046No
101GRIP2glutamate receptor interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:23841]254570.000-0.1077No
102TTC22tetratricopeptide repeat domain 22 [Source:HGNC Symbol;Acc:HGNC:26067]254950.000-0.1087No
103SMPXsmall muscle protein X-linked [Source:HGNC Symbol;Acc:HGNC:11122]256990.000-0.1142No
104PDCD1LG2programmed cell death 1 ligand 2 [Source:HGNC Symbol;Acc:HGNC:18731]257950.000-0.1167No
105FNDC8fibronectin type III domain containing 8 [Source:HGNC Symbol;Acc:HGNC:25286]260720.000-0.1242No
106ITGA2integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137]266570.000-0.1400No
107MAGEA6MAGE family member A6 [Source:HGNC Symbol;Acc:HGNC:6804]269050.000-0.1467No
108TMEM238Ltransmembrane protein 238 like [Source:HGNC Symbol;Acc:HGNC:44356]270490.000-0.1506No
109CELA2Bchymotrypsin like elastase 2B [Source:HGNC Symbol;Acc:HGNC:29995]272920.000-0.1571No
110AKT2AKT serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:392]28147-0.075-0.1793No
111LINC00472long intergenic non-protein coding RNA 472 [Source:HGNC Symbol;Acc:HGNC:21380]28695-0.148-0.1924No
112HPNhepsin [Source:HGNC Symbol;Acc:HGNC:5155]28844-0.172-0.1944No
113UGT1A10UDP glucuronosyltransferase family 1 member A10 [Source:HGNC Symbol;Acc:HGNC:12531]28897-0.177-0.1937No
114LDB3LIM domain binding 3 [Source:HGNC Symbol;Acc:HGNC:15710]29142-0.204-0.1979No
115GPR3G protein-coupled receptor 3 [Source:HGNC Symbol;Acc:HGNC:4484]29238-0.219-0.1979No
116LAG3lymphocyte activating 3 [Source:HGNC Symbol;Acc:HGNC:6476]29469-0.246-0.2013No
117CLSTN3calsyntenin 3 [Source:HGNC Symbol;Acc:HGNC:18371]30119-0.344-0.2148No
118DOCK2dedicator of cytokinesis 2 [Source:HGNC Symbol;Acc:HGNC:2988]30484-0.399-0.2199No
119FABP3fatty acid binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3557]30869-0.462-0.2249No
120SARM1sterile alpha and TIR motif containing 1 [Source:HGNC Symbol;Acc:HGNC:17074]31025-0.483-0.2234No
121ZNF821zinc finger protein 821 [Source:HGNC Symbol;Acc:HGNC:28043]31758-0.618-0.2360No
122TMEM176Btransmembrane protein 176B [Source:HGNC Symbol;Acc:HGNC:29596]31761-0.618-0.2288No
123KIF5Ckinesin family member 5C [Source:HGNC Symbol;Acc:HGNC:6325]32031-0.677-0.2281No
124AURKCaurora kinase C [Source:HGNC Symbol;Acc:HGNC:11391]32290-0.717-0.2266No
125ABCB1ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]32708-0.826-0.2282No
126ZBTB44zinc finger and BTB domain containing 44 [Source:HGNC Symbol;Acc:HGNC:25001]32892-0.873-0.2229No
127OGDHLoxoglutarate dehydrogenase like [Source:HGNC Symbol;Acc:HGNC:25590]32895-0.875-0.2127No
128B3GNTL1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 [Source:HGNC Symbol;Acc:HGNC:21727]33332-0.985-0.2129No
129NDOR1NADPH dependent diflavin oxidoreductase 1 [Source:HGNC Symbol;Acc:HGNC:29838]33361-0.995-0.2020No
130ANGPTL4angiopoietin like 4 [Source:HGNC Symbol;Acc:HGNC:16039]34518-1.388-0.2170No
131ATG10autophagy related 10 [Source:HGNC Symbol;Acc:HGNC:20315]34818-1.533-0.2071No
132SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 [Source:HGNC Symbol;Acc:HGNC:10671]34861-1.557-0.1899No
133JAK3Janus kinase 3 [Source:HGNC Symbol;Acc:HGNC:6193]35272-1.769-0.1802No
134HROBhomologous recombination factor with OB-fold [Source:HGNC Symbol;Acc:HGNC:28460]35845-2.167-0.1702No
135BANK1B cell scaffold protein with ankyrin repeats 1 [Source:HGNC Symbol;Acc:HGNC:18233]35880-2.201-0.1453No
136TMEM158transmembrane protein 158 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:30293]35904-2.222-0.1198No
137SLCO4A1solute carrier organic anion transporter family member 4A1 [Source:HGNC Symbol;Acc:HGNC:10953]36057-2.343-0.0964No
138NRP1neuropilin 1 [Source:HGNC Symbol;Acc:HGNC:8004]36352-2.643-0.0733No
139CX3CR1C-X3-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:2558]36914-3.685-0.0452No
140CYTIPcytohesin 1 interacting protein [Source:HGNC Symbol;Acc:HGNC:9506]37025-4.2510.0018No
Table: GSEA details [plain text format]



Fig 2: KRAS.LUNG_UP.V1_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KRAS.LUNG_UP.V1_UP: Random ES distribution   
Gene set null distribution of ES for KRAS.LUNG_UP.V1_UP