Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_ANDROGEN_RESPONSE
Enrichment Score (ES)0.34828493
Normalized Enrichment Score (NES)1.1183525
Nominal p-value0.19453925
FDR q-value0.26754248
FWER p-Value0.909
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ANDROGEN_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Sordsorbitol dehydrogenase [Source:MGI Symbol;Acc:MGI:98266]512.5800.0293Yes
2Sgk1serum/glucocorticoid regulated kinase 1 [Source:MGI Symbol;Acc:MGI:1340062]552.5430.0597Yes
3Pmepa1prostate transmembrane protein, androgen induced 1 [Source:MGI Symbol;Acc:MGI:1929600]662.4830.0892Yes
4B2mbeta-2 microglobulin [Source:MGI Symbol;Acc:MGI:88127]3471.7080.1007Yes
5Itgavintegrin alpha V [Source:MGI Symbol;Acc:MGI:96608]3571.6940.1207Yes
6Akap12A kinase (PRKA) anchor protein (gravin) 12 [Source:MGI Symbol;Acc:MGI:1932576]4351.6110.1376Yes
7Herc3hect domain and RLD 3 [Source:MGI Symbol;Acc:MGI:1921248]5061.5260.1536Yes
8Abhd2abhydrolase domain containing 2 [Source:MGI Symbol;Acc:MGI:1914344]5161.5210.1716Yes
9Zbtb10zinc finger and BTB domain containing 10 [Source:MGI Symbol;Acc:MGI:2139883]6691.4060.1836Yes
10Cdk6cyclin-dependent kinase 6 [Source:MGI Symbol;Acc:MGI:1277162]7131.3710.1986Yes
11Steap4STEAP family member 4 [Source:MGI Symbol;Acc:MGI:1923560]7751.3350.2127Yes
12Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta [Source:MGI Symbol;Acc:MGI:2444812]8831.2800.2246Yes
13Ccnd3cyclin D3 [Source:MGI Symbol;Acc:MGI:88315]8931.2740.2396Yes
14Actn1actinin, alpha 1 [Source:MGI Symbol;Acc:MGI:2137706]10601.1920.2486Yes
15Ptk2bPTK2 protein tyrosine kinase 2 beta [Source:MGI Symbol;Acc:MGI:104908]11811.1510.2585Yes
16B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:95705]12301.1300.2705Yes
17Zmiz1zinc finger, MIZ-type containing 1 [Source:MGI Symbol;Acc:MGI:3040693]12551.1200.2832Yes
18MertkMER proto-oncogene tyrosine kinase [Source:MGI Symbol;Acc:MGI:96965]15381.0210.2864Yes
19Srfserum response factor [Source:MGI Symbol;Acc:MGI:106658]15561.0160.2980Yes
20Ncoa4nuclear receptor coactivator 4 [Source:MGI Symbol;Acc:MGI:1350932]15881.0080.3091Yes
21Ptpn21protein tyrosine phosphatase, non-receptor type 21 [Source:MGI Symbol;Acc:MGI:1344406]15891.0080.3212Yes
22Arid5bAT rich interactive domain 5B (MRF1-like) [Source:MGI Symbol;Acc:MGI:2175912]16410.9920.3315Yes
23Abcc4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [Source:MGI Symbol;Acc:MGI:2443111]18090.9540.3375Yes
24Ankprogressive ankylosis [Source:MGI Symbol;Acc:MGI:3045421]21040.8860.3387Yes
25Akt1thymoma viral proto-oncogene 1 [Source:MGI Symbol;Acc:MGI:87986]21360.8790.3483Yes
26Elk4ELK4, member of ETS oncogene family [Source:MGI Symbol;Acc:MGI:102853]33810.6580.3162No
27Dhcr2424-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1922004]34430.6470.3220No
28Rab4aRAB4A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:105069]39220.5670.3135No
29Pias1protein inhibitor of activated STAT 1 [Source:MGI Symbol;Acc:MGI:1913125]39460.5640.3195No
30Ube2j1ubiquitin-conjugating enzyme E2J 1 [Source:MGI Symbol;Acc:MGI:1926245]41320.5400.3200No
31Adrm1adhesion regulating molecule 1 26S proteasome ubiquitin receptor [Source:MGI Symbol;Acc:MGI:1929289]56770.3880.2751No
32Gucy1a1guanylate cyclase 1, soluble, alpha 1 [Source:MGI Symbol;Acc:MGI:1926562]58310.3770.2747No
33SpdefSAM pointed domain containing ets transcription factor [Source:MGI Symbol;Acc:MGI:1353422]61270.3690.2697No
34Uap1UDP-N-acetylglucosamine pyrophosphorylase 1 [Source:MGI Symbol;Acc:MGI:1334459]64620.3320.2629No
35Sec24dSec24 related gene family, member D (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916858]68650.2950.2536No
36Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]70190.2760.2520No
37Stk39serine/threonine kinase 39 [Source:MGI Symbol;Acc:MGI:1858416]88490.2260.1959No
38Cenpncentromere protein N [Source:MGI Symbol;Acc:MGI:1919405]89680.2180.1948No
39Tpd52tumor protein D52 [Source:MGI Symbol;Acc:MGI:107749]89840.2160.1969No
40Bmpr1bbone morphogenetic protein receptor, type 1B [Source:MGI Symbol;Acc:MGI:107191]92540.1930.1906No
41Lman1lectin, mannose-binding, 1 [Source:MGI Symbol;Acc:MGI:1917611]92710.1910.1923No
42Rrp12ribosomal RNA processing 12 homolog [Source:MGI Symbol;Acc:MGI:2147437]93520.1820.1920No
43Cdc14bCDC14 cell division cycle 14B [Source:MGI Symbol;Acc:MGI:2441808]95990.1550.1859No
44Inpp4binositol polyphosphate-4-phosphatase, type II [Source:MGI Symbol;Acc:MGI:2158925]97520.1360.1827No
45Slc38a2solute carrier family 38, member 2 [Source:MGI Symbol;Acc:MGI:1915010]102520.0960.1678No
46Hpgdhydroxyprostaglandin dehydrogenase 15 (NAD) [Source:MGI Symbol;Acc:MGI:108085]103390.0870.1661No
47Pa2g4proliferation-associated 2G4 [Source:MGI Symbol;Acc:MGI:894684]109270.0250.1475No
48Nkx3-1NK3 homeobox 1 [Source:MGI Symbol;Acc:MGI:97352]128590.0000.0855No
49Makmale germ cell-associated kinase [Source:MGI Symbol;Acc:MGI:96913]153530.0000.0055No
50Arxes2adipocyte-related X-chromosome expressed sequence 2 [Source:MGI Symbol;Acc:MGI:1924226]207550.000-0.1680No
51Gpd1lglycerol-3-phosphate dehydrogenase 1-like [Source:MGI Symbol;Acc:MGI:1289257]21418-0.060-0.1885No
52Ccnd1cyclin D1 [Source:MGI Symbol;Acc:MGI:88313]21485-0.069-0.1898No
53Dnajb9DnaJ heat shock protein family (Hsp40) member B9 [Source:MGI Symbol;Acc:MGI:1351618]21693-0.087-0.1954No
54Selenopselenoprotein P [Source:MGI Symbol;Acc:MGI:894288]22112-0.130-0.2073No
55Vapavesicle-associated membrane protein, associated protein A [Source:MGI Symbol;Acc:MGI:1353561]22197-0.139-0.2083No
56Acsl3acyl-CoA synthetase long-chain family member 3 [Source:MGI Symbol;Acc:MGI:1921455]22221-0.142-0.2073No
57Idi1isopentenyl-diphosphate delta isomerase [Source:MGI Symbol;Acc:MGI:2442264]22696-0.158-0.2207No
58Ube2iubiquitin-conjugating enzyme E2I [Source:MGI Symbol;Acc:MGI:107365]23231-0.219-0.2352No
59Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast) [Source:MGI Symbol;Acc:MGI:1916051]23296-0.226-0.2345No
60Ell2elongation factor for RNA polymerase II 2 [Source:MGI Symbol;Acc:MGI:2183438]23423-0.239-0.2357No
61Rps6ka3ribosomal protein S6 kinase polypeptide 3 [Source:MGI Symbol;Acc:MGI:104557]23737-0.261-0.2426No
62Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159]23752-0.262-0.2399No
63Srp19signal recognition particle 19 [Source:MGI Symbol;Acc:MGI:1913634]23770-0.264-0.2373No
64Iqgap2IQ motif containing GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:2449975]24130-0.301-0.2452No
65Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Source:MGI Symbol;Acc:MGI:107592]24267-0.317-0.2458No
66Pdlim5PDZ and LIM domain 5 [Source:MGI Symbol;Acc:MGI:1927489]24353-0.327-0.2446No
67Gsrglutathione reductase [Source:MGI Symbol;Acc:MGI:95804]25354-0.383-0.2721No
68Plpp1phospholipid phosphatase 1 [Source:MGI Symbol;Acc:MGI:108412]25453-0.399-0.2705No
69Tmem50atransmembrane protein 50A [Source:MGI Symbol;Acc:MGI:1919067]26224-0.473-0.2895No
70Sat1spermidine/spermine N1-acetyl transferase 1 [Source:MGI Symbol;Acc:MGI:98233]26949-0.585-0.3057No
71Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 5 [Source:MGI Symbol;Acc:MGI:104517]26979-0.589-0.2996No
72Pgm3phosphoglucomutase 3 [Source:MGI Symbol;Acc:MGI:97566]27829-0.735-0.3181No
73Tsc22d1TSC22 domain family, member 1 [Source:MGI Symbol;Acc:MGI:109127]27838-0.738-0.3095No
74Slc26a2solute carrier family 26 (sulfate transporter), member 2 [Source:MGI Symbol;Acc:MGI:892977]27991-0.770-0.3051No
75Tnfaip8tumor necrosis factor, alpha-induced protein 8 [Source:MGI Symbol;Acc:MGI:2147191]27995-0.770-0.2960No
76Sms-psspermine synthase, pseudogene [Source:MGI Symbol;Acc:MGI:3705601]28245-0.829-0.2940No
77Azgp1alpha-2-glycoprotein 1, zinc [Source:MGI Symbol;Acc:MGI:103163]28376-0.858-0.2879No
78Dbidiazepam binding inhibitor [Source:MGI Symbol;Acc:MGI:94865]28492-0.885-0.2810No
79Appbp2amyloid beta precursor protein (cytoplasmic tail) binding protein 2 [Source:MGI Symbol;Acc:MGI:1914134]28531-0.896-0.2715No
80Homer2homer scaffolding protein 2 [Source:MGI Symbol;Acc:MGI:1347354]28555-0.902-0.2614No
81Krt8keratin 8 [Source:MGI Symbol;Acc:MGI:96705]28607-0.917-0.2520No
82Fads1fatty acid desaturase 1 [Source:MGI Symbol;Acc:MGI:1923517]28716-0.948-0.2441No
83Insig1insulin induced gene 1 [Source:MGI Symbol;Acc:MGI:1916289]29472-1.190-0.2541No
84Fkbp5FK506 binding protein 5 [Source:MGI Symbol;Acc:MGI:104670]30051-1.459-0.2551No
85Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6 [Source:MGI Symbol;Acc:MGI:95606]30125-1.505-0.2394No
86Ngly1N-glycanase 1 [Source:MGI Symbol;Acc:MGI:1913276]30195-1.554-0.2230No
87LifrLIF receptor alpha [Source:MGI Symbol;Acc:MGI:96788]30201-1.557-0.2045No
88H1f0H1.0 linker histone [Source:MGI Symbol;Acc:MGI:95893]30335-1.653-0.1889No
89Mafavian musculoaponeurotic fibrosarcoma oncogene homolog [Source:MGI Symbol;Acc:MGI:96909]30594-1.909-0.1743No
90Map7microtubule-associated protein 7 [Source:MGI Symbol;Acc:MGI:1328328]30684-2.018-0.1530No
91Ndrg1N-myc downstream regulated gene 1 [Source:MGI Symbol;Acc:MGI:1341799]30702-2.042-0.1290No
92Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [Source:MGI Symbol;Acc:MGI:109249]30797-2.164-0.1061No
93Tmprss2transmembrane protease, serine 2 [Source:MGI Symbol;Acc:MGI:1354381]30828-2.213-0.0805No
94Hsd17b14hydroxysteroid (17-beta) dehydrogenase 14 [Source:MGI Symbol;Acc:MGI:1913315]30865-2.273-0.0544No
95Krt19keratin 19 [Source:MGI Symbol;Acc:MGI:96693]31011-2.625-0.0276No
96Aldh1a3aldehyde dehydrogenase family 1, subfamily A3 [Source:MGI Symbol;Acc:MGI:1861722]31088-2.9030.0048No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ANDROGEN_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ANDROGEN_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ANDROGEN_RESPONSE