Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_CHOLESTEROL_HOMEOSTASIS
Enrichment Score (ES)-0.49629638
Normalized Enrichment Score (NES)-1.3988549
Nominal p-value0.036390103
FDR q-value0.03906667
FWER p-Value0.419
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_CHOLESTEROL_HOMEOSTASIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Cpeb2cytoplasmic polyadenylation element binding protein 2 [Source:MGI Symbol;Acc:MGI:2442640]1372.1440.0306No
2Hsd17b7hydroxysteroid (17-beta) dehydrogenase 7 [Source:MGI Symbol;Acc:MGI:1330808]3661.6850.0508No
3Atxn2ataxin 2 [Source:MGI Symbol;Acc:MGI:1277223]7411.3540.0609No
4Antxr2anthrax toxin receptor 2 [Source:MGI Symbol;Acc:MGI:1919164]9001.2710.0766No
5Anxa5annexin A5 [Source:MGI Symbol;Acc:MGI:106008]15261.0250.0732No
6Abca2ATP-binding cassette, sub-family A (ABC1), member 2 [Source:MGI Symbol;Acc:MGI:99606]22370.8590.0645No
7Gnai1guanine nucleotide binding protein (G protein), alpha inhibiting 1 [Source:MGI Symbol;Acc:MGI:95771]26760.7690.0630No
8Ctnnb1catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]30730.6980.0617No
9Gusbglucuronidase, beta [Source:MGI Symbol;Acc:MGI:95872]30960.6930.0723No
10Cxcl16chemokine (C-X-C motif) ligand 16 [Source:MGI Symbol;Acc:MGI:1932682]31060.6910.0833No
11Jag1jagged 1 [Source:MGI Symbol;Acc:MGI:1095416]31760.6830.0922No
12Fdft1farnesyl diphosphate farnesyl transferase 1 [Source:MGI Symbol;Acc:MGI:102706]33170.6620.0985No
13Stard4StAR-related lipid transfer (START) domain containing 4 [Source:MGI Symbol;Acc:MGI:2156764]34100.6540.1062No
14Cluclusterin [Source:MGI Symbol;Acc:MGI:88423]35500.6260.1120No
15Pnrc1proline-rich nuclear receptor coactivator 1 [Source:MGI Symbol;Acc:MGI:1917838]35780.6220.1213No
16Lgmnlegumain [Source:MGI Symbol;Acc:MGI:1330838]36080.6160.1304No
17S100a11S100 calcium binding protein A11 [Source:MGI Symbol;Acc:MGI:1338798]38380.5800.1325No
18Lgals3lectin, galactose binding, soluble 3 [Source:MGI Symbol;Acc:MGI:96778]40150.5570.1359No
19Mvdmevalonate (diphospho) decarboxylase [Source:MGI Symbol;Acc:MGI:2179327]46080.5040.1252No
20Ldlrlow density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:96765]47200.4900.1296No
21Sqlesqualene epoxidase [Source:MGI Symbol;Acc:MGI:109296]48400.4750.1336No
22Alcamactivated leukocyte cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1313266]62360.3590.0947No
23Sc5dsterol-C5-desaturase [Source:MGI Symbol;Acc:MGI:1353611]64110.3370.0946No
24Gldcglycine decarboxylase [Source:MGI Symbol;Acc:MGI:1341155]73020.2650.0703No
25Srebf2sterol regulatory element binding factor 2 [Source:MGI Symbol;Acc:MGI:107585]89760.2170.0202No
26Dhcr77-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1298378]96580.1480.0008No
27Mvkmevalonate kinase [Source:MGI Symbol;Acc:MGI:107624]96790.1460.0025No
28Lpllipoprotein lipase [Source:MGI Symbol;Acc:MGI:96820]103810.083-0.0186No
29Cyp51cytochrome P450, family 51 [Source:MGI Symbol;Acc:MGI:106040]107720.044-0.0304No
30Avpr1aarginine vasopressin receptor 1A [Source:MGI Symbol;Acc:MGI:1859216]135920.000-0.1209No
31Plscr1phospholipid scramblase 1 [Source:MGI Symbol;Acc:MGI:893575]21020-0.012-0.3590No
32NsdhlNAD(P) dependent steroid dehydrogenase-like [Source:MGI Symbol;Acc:MGI:1099438]21050-0.018-0.3596No
33Plaurplasminogen activator, urokinase receptor [Source:MGI Symbol;Acc:MGI:97612]21549-0.074-0.3744No
34Idi1isopentenyl-diphosphate delta isomerase [Source:MGI Symbol;Acc:MGI:2442264]22696-0.158-0.4086No
35Tnfrsf12atumor necrosis factor receptor superfamily, member 12a [Source:MGI Symbol;Acc:MGI:1351484]22729-0.163-0.4069No
36Fbxo6F-box protein 6 [Source:MGI Symbol;Acc:MGI:1354743]23160-0.211-0.4173No
37Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [Source:MGI Symbol;Acc:MGI:107561]23546-0.246-0.4256No
38Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159]23752-0.262-0.4279No
39Lsslanosterol synthase [Source:MGI Symbol;Acc:MGI:1336155]24235-0.313-0.4383No
40Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Source:MGI Symbol;Acc:MGI:107592]24267-0.317-0.4341No
41Actg1actin, gamma, cytoplasmic 1 [Source:MGI Symbol;Acc:MGI:87906]24501-0.346-0.4359No
42Adh4alcohol dehydrogenase 4 (class II), pi polypeptide [Source:MGI Symbol;Acc:MGI:1349472]24643-0.357-0.4346No
43Acat2acetyl-Coenzyme A acetyltransferase 2 [Source:MGI Symbol;Acc:MGI:87871]26368-0.492-0.4819No
44Cd9CD9 antigen [Source:MGI Symbol;Acc:MGI:88348]26656-0.532-0.4824No
45Ebpphenylalkylamine Ca2+ antagonist (emopamil) binding protein [Source:MGI Symbol;Acc:MGI:107822]26681-0.538-0.4744No
46Trp53inp1transformation related protein 53 inducible nuclear protein 1 [Source:MGI Symbol;Acc:MGI:1926609]27179-0.623-0.4802No
47Ppargperoxisome proliferator activated receptor gamma [Source:MGI Symbol;Acc:MGI:97747]27587-0.691-0.4820No
48Stx5asyntaxin 5A [Source:MGI Symbol;Acc:MGI:1928483]28034-0.780-0.4836Yes
49Fads2fatty acid desaturase 2 [Source:MGI Symbol;Acc:MGI:1930079]28042-0.781-0.4710Yes
50Fdpsfarnesyl diphosphate synthetase [Source:MGI Symbol;Acc:MGI:104888]28227-0.823-0.4635Yes
51Tm7sf2transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416]28411-0.868-0.4552Yes
52Pcyt2phosphate cytidylyltransferase 2, ethanolamine [Source:MGI Symbol;Acc:MGI:1915921]28499-0.888-0.4435Yes
53Ethe1ethylmalonic encephalopathy 1 [Source:MGI Symbol;Acc:MGI:1913321]28661-0.932-0.4335Yes
54Gstm7glutathione S-transferase, mu 7 [Source:MGI Symbol;Acc:MGI:1915562]29239-1.101-0.4340Yes
55Nfil3nuclear factor, interleukin 3, regulated [Source:MGI Symbol;Acc:MGI:109495]29296-1.121-0.4175Yes
56Tmem97transmembrane protein 97 [Source:MGI Symbol;Acc:MGI:1916321]29355-1.141-0.4008Yes
57Fasnfatty acid synthase [Source:MGI Symbol;Acc:MGI:95485]29614-1.246-0.3887Yes
58Chkacholine kinase alpha [Source:MGI Symbol;Acc:MGI:107760]29619-1.248-0.3685Yes
59Gpx8glutathione peroxidase 8 (putative) [Source:MGI Symbol;Acc:MGI:1916840]29635-1.255-0.3485Yes
60Errfi1ERBB receptor feedback inhibitor 1 [Source:MGI Symbol;Acc:MGI:1921405]29836-1.341-0.3330Yes
61Pmvkphosphomevalonate kinase [Source:MGI Symbol;Acc:MGI:1915853]29931-1.391-0.3133Yes
62Atf3activating transcription factor 3 [Source:MGI Symbol;Acc:MGI:109384]30287-1.613-0.2984Yes
63Ech1enoyl coenzyme A hydratase 1, peroxisomal [Source:MGI Symbol;Acc:MGI:1858208]30334-1.652-0.2729Yes
64Fabp5fatty acid binding protein 5, epidermal [Source:MGI Symbol;Acc:MGI:101790]30410-1.709-0.2474Yes
65Pdk3pyruvate dehydrogenase kinase, isoenzyme 3 [Source:MGI Symbol;Acc:MGI:2384308]30516-1.813-0.2212Yes
66Niban1niban apoptosis regulator 1 [Source:MGI Symbol;Acc:MGI:2137237]30586-1.899-0.1924Yes
67Aldocaldolase C, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:101863]30700-2.040-0.1627Yes
68Mal2mal, T cell differentiation protein 2 [Source:MGI Symbol;Acc:MGI:2146021]30782-2.145-0.1303Yes
69Acss2acyl-CoA synthetase short-chain family member 2 [Source:MGI Symbol;Acc:MGI:1890410]30838-2.227-0.0957Yes
70Atf5activating transcription factor 5 [Source:MGI Symbol;Acc:MGI:2141857]31085-2.899-0.0563Yes
71Trib3tribbles pseudokinase 3 [Source:MGI Symbol;Acc:MGI:1345675]31182-3.7500.0018Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_CHOLESTEROL_HOMEOSTASIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_CHOLESTEROL_HOMEOSTASIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_CHOLESTEROL_HOMEOSTASIS