Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_DNA_REPAIR
Enrichment Score (ES)-0.3478794
Normalized Enrichment Score (NES)-1.070014
Nominal p-value0.3040629
FDR q-value0.40358552
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_DNA_REPAIR   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Pom121nuclear pore membrane protein 121 [Source:MGI Symbol;Acc:MGI:2137624]6051.449-0.0027No
2Stx3syntaxin 3 [Source:MGI Symbol;Acc:MGI:103077]9741.234-0.0002No
3Gtf2h1general transcription factor II H, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1277216]9831.2280.0138No
4Ncbp2nuclear cap binding protein subunit 2 [Source:MGI Symbol;Acc:MGI:1915342]10091.2180.0271No
5Gtf3c5general transcription factor IIIC, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1917489]10131.2160.0411No
6Vps37bvacuolar protein sorting 37B [Source:MGI Symbol;Acc:MGI:1916724]13161.0990.0442No
7Adaadenosine deaminase [Source:MGI Symbol;Acc:MGI:87916]14761.0430.0512No
8Adcy6adenylate cyclase 6 [Source:MGI Symbol;Acc:MGI:87917]15181.0260.0618No
9Npr2natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]15421.0210.0729No
10Dgcr8DGCR8, microprocessor complex subunit [Source:MGI Symbol;Acc:MGI:2151114]15541.0160.0843No
11Sac3d1SAC3 domain containing 1 [Source:MGI Symbol;Acc:MGI:1913656]15921.0070.0948No
12Snapc4small nuclear RNA activating complex, polypeptide 4 [Source:MGI Symbol;Acc:MGI:2443935]17130.9760.1022No
13Eloaelongin A [Source:MGI Symbol;Acc:MGI:1351315]19650.9140.1048No
14Ak1adenylate kinase 1 [Source:MGI Symbol;Acc:MGI:87977]21790.8710.1080No
15Itpainosine triphosphatase (nucleoside triphosphate pyrophosphatase) [Source:MGI Symbol;Acc:MGI:96622]22060.8660.1172No
16Nudt9nudix hydrolase 9 [Source:MGI Symbol;Acc:MGI:1921417]24250.8210.1197No
17Taf1cTATA-box binding protein associated factor, RNA polymerase I, C [Source:MGI Symbol;Acc:MGI:109576]26050.7840.1231No
18Dad1defender against cell death 1 [Source:MGI Symbol;Acc:MGI:101912]28890.7330.1225No
19Ercc1excision repair cross-complementing rodent repair deficiency, complementation group 1 [Source:MGI Symbol;Acc:MGI:95412]29810.7170.1279No
20Dctn4dynactin 4 [Source:MGI Symbol;Acc:MGI:1914915]31640.6850.1300No
21Polhpolymerase (DNA directed), eta (RAD 30 related) [Source:MGI Symbol;Acc:MGI:1891457]35660.6240.1243No
22Tarbp2TARBP2, RISC loading complex RNA binding subunit [Source:MGI Symbol;Acc:MGI:103027]37510.5930.1253No
23Ssrp1structure specific recognition protein 1 [Source:MGI Symbol;Acc:MGI:107912]38570.5770.1286No
24Upf3bUPF3 regulator of nonsense transcripts homolog B (yeast) [Source:MGI Symbol;Acc:MGI:1915384]39240.5670.1330No
25Pola2polymerase (DNA directed), alpha 2 [Source:MGI Symbol;Acc:MGI:99690]39540.5630.1386No
26Pcnaproliferating cell nuclear antigen [Source:MGI Symbol;Acc:MGI:97503]42360.5270.1357No
27Ercc5excision repair cross-complementing rodent repair deficiency, complementation group 5 [Source:MGI Symbol;Acc:MGI:103582]44770.5190.1340No
28Ercc3excision repair cross-complementing rodent repair deficiency, complementation group 3 [Source:MGI Symbol;Acc:MGI:95414]45360.5140.1381No
29Nelfbnegative elongation factor complex member B [Source:MGI Symbol;Acc:MGI:1931035]46940.4950.1388No
30Fen1flap structure specific endonuclease 1 [Source:MGI Symbol;Acc:MGI:102779]48350.4760.1398No
31Ellelongation factor RNA polymerase II [Source:MGI Symbol;Acc:MGI:109377]52610.4200.1310No
32Rae1ribonucleic acid export 1 [Source:MGI Symbol;Acc:MGI:1913929]53800.4070.1320No
33Pnppurine-nucleoside phosphorylase [Source:MGI Symbol;Acc:MGI:97365]56280.3930.1286No
34Adrm1adhesion regulating molecule 1 26S proteasome ubiquitin receptor [Source:MGI Symbol;Acc:MGI:1929289]56770.3880.1315No
35Rpa2replication protein A2 [Source:MGI Symbol;Acc:MGI:1339939]56860.3860.1357No
36Ercc4excision repair cross-complementing rodent repair deficiency, complementation group 4 [Source:MGI Symbol;Acc:MGI:1354163]57610.3780.1377No
37Edf1endothelial differentiation-related factor 1 [Source:MGI Symbol;Acc:MGI:1891227]61210.3690.1305No
38Srsf6serine and arginine-rich splicing factor 6 [Source:MGI Symbol;Acc:MGI:1915246]61220.3690.1348No
39Tymsthymidylate synthase [Source:MGI Symbol;Acc:MGI:98878]61230.3690.1390No
40Gtf2f1general transcription factor IIF, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1923848]61940.3630.1410No
41Nelfcdnegative elongation factor complex member C/D, Th1l [Source:MGI Symbol;Acc:MGI:1926424]63470.3450.1401No
42Nfx1nuclear transcription factor, X-box binding 1 [Source:MGI Symbol;Acc:MGI:1921414]64320.3350.1413No
43Dutdeoxyuridine triphosphatase [Source:MGI Symbol;Acc:MGI:1346051]65900.3170.1399No
44Eif1beukaryotic translation initiation factor 1B [Source:MGI Symbol;Acc:MGI:1916219]66870.3060.1404No
45Ak3adenylate kinase 3 [Source:MGI Symbol;Acc:MGI:1860835]69180.2890.1364No
46Aprtadenine phosphoribosyl transferase [Source:MGI Symbol;Acc:MGI:88061]69230.2880.1396No
47Surf1surfeit gene 1 [Source:MGI Symbol;Acc:MGI:98443]69530.2840.1419No
48Smad5SMAD family member 5 [Source:MGI Symbol;Acc:MGI:1328787]74390.2490.1292No
49Supt5suppressor of Ty 5, DSIF elongation factor subunit [Source:MGI Symbol;Acc:MGI:1202400]74970.2420.1302No
50Rad51RAD51 recombinase [Source:MGI Symbol;Acc:MGI:97890]75710.2400.1306No
51Clp1CLP1, cleavage and polyadenylation factor I subunit [Source:MGI Symbol;Acc:MGI:2138968]75840.2390.1330No
52Hcls1hematopoietic cell specific Lyn substrate 1 [Source:MGI Symbol;Acc:MGI:104568]80410.2260.1210No
53Gsdmegasdermin E [Source:MGI Symbol;Acc:MGI:1889850]92180.1970.0854No
54Polr2apolymerase (RNA) II (DNA directed) polypeptide A [Source:MGI Symbol;Acc:MGI:98086]94050.1770.0815No
55Cstf3cleavage stimulation factor, 3' pre-RNA, subunit 3 [Source:MGI Symbol;Acc:MGI:1351825]95810.1570.0777No
56Ccnocyclin O [Source:MGI Symbol;Acc:MGI:2145534]96760.1460.0764No
57Polr2dpolymerase (RNA) II (DNA directed) polypeptide D [Source:MGI Symbol;Acc:MGI:1916491]102880.0940.0578No
58Ago4argonaute RISC catalytic subunit 4 [Source:MGI Symbol;Acc:MGI:1924100]103430.0860.0571No
59Rfc2replication factor C (activator 1) 2 [Source:MGI Symbol;Acc:MGI:1341868]103850.0830.0567No
60ZwintZW10 interactor [Source:MGI Symbol;Acc:MGI:1289227]104380.0790.0560No
61Sdcbpsyndecan binding protein [Source:MGI Symbol;Acc:MGI:1337026]105900.0640.0518No
62Gtf2h3general transcription factor IIH, polypeptide 3 [Source:MGI Symbol;Acc:MGI:1277143]106790.0530.0496No
63Rev3lREV3 like, DNA directed polymerase zeta catalytic subunit [Source:MGI Symbol;Acc:MGI:1337131]107340.0490.0485No
64Sf3a3splicing factor 3a, subunit 3 [Source:MGI Symbol;Acc:MGI:1922312]109610.0200.0414No
65Ercc2excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413]109880.0170.0408No
66Usp11ubiquitin specific peptidase 11 [Source:MGI Symbol;Acc:MGI:2384312]21041-0.015-0.2824No
67Trp53transformation related protein 53 [Source:MGI Symbol;Acc:MGI:98834]21201-0.037-0.2870No
68Polr2ipolymerase (RNA) II (DNA directed) polypeptide I [Source:MGI Symbol;Acc:MGI:1917170]21332-0.050-0.2906No
69Taf6TATA-box binding protein associated factor 6 [Source:MGI Symbol;Acc:MGI:109129]21372-0.054-0.2913No
70Taf9TATA-box binding protein associated factor 9 [Source:MGI Symbol;Acc:MGI:1888697]21455-0.065-0.2932No
71Umpsuridine monophosphate synthetase [Source:MGI Symbol;Acc:MGI:1298388]21626-0.081-0.2977No
72Polr2jpolymerase (RNA) II (DNA directed) polypeptide J [Source:MGI Symbol;Acc:MGI:109582]21648-0.083-0.2974No
73Vps37dvacuolar protein sorting 37D [Source:MGI Symbol;Acc:MGI:2159402]21677-0.086-0.2973No
74Rfc5replication factor C (activator 1) 5 [Source:MGI Symbol;Acc:MGI:1919401]21710-0.089-0.2973No
75AlyrefAly/REF export factor [Source:MGI Symbol;Acc:MGI:1341044]21804-0.097-0.2992No
76Ralav-ral simian leukemia viral oncogene A (ras related) [Source:MGI Symbol;Acc:MGI:1927243]21918-0.110-0.3015No
77Brf2BRF2, RNA polymerase III transcription initiation factor 50kDa subunit [Source:MGI Symbol;Acc:MGI:1913903]22108-0.129-0.3061No
78Pole4polymerase (DNA-directed), epsilon 4 (p12 subunit) [Source:MGI Symbol;Acc:MGI:1914229]22143-0.133-0.3056No
79Nudt21nudix hydrolase 21 [Source:MGI Symbol;Acc:MGI:1915469]22226-0.143-0.3066No
80Zfp707zinc finger protein 707 [Source:MGI Symbol;Acc:MGI:1916270]22644-0.150-0.3183No
81Pde4bphosphodiesterase 4B, cAMP specific [Source:MGI Symbol;Acc:MGI:99557]22652-0.151-0.3168No
82Taf13TATA-box binding protein associated factor 13 [Source:MGI Symbol;Acc:MGI:1913500]22733-0.163-0.3175No
83Gtf2bgeneral transcription factor IIB [Source:MGI Symbol;Acc:MGI:2385191]22853-0.172-0.3193No
84Pde6gphosphodiesterase 6G, cGMP-specific, rod, gamma [Source:MGI Symbol;Acc:MGI:97526]22980-0.188-0.3212No
85Pola1polymerase (DNA directed), alpha 1 [Source:MGI Symbol;Acc:MGI:99660]23096-0.202-0.3225No
86Polr1hRNA polymerase I subunit H [Source:MGI Symbol;Acc:MGI:1913386]23099-0.202-0.3202No
87Pollpolymerase (DNA directed), lambda [Source:MGI Symbol;Acc:MGI:1889000]23128-0.207-0.3187No
88Cetn2centrin 2 [Source:MGI Symbol;Acc:MGI:1347085]23217-0.218-0.3190No
89Polr2fpolymerase (RNA) II (DNA directed) polypeptide F [Source:MGI Symbol;Acc:MGI:1349393]23322-0.228-0.3197No
90Sec61a1Sec61 alpha 1 subunit (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1858417]23406-0.237-0.3196No
91Ddb1damage specific DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1202384]23559-0.247-0.3217No
92Impdh2inosine monophosphate dehydrogenase 2 [Source:MGI Symbol;Acc:MGI:109367]23757-0.263-0.3249No
93Pold1polymerase (DNA directed), delta 1, catalytic subunit [Source:MGI Symbol;Acc:MGI:97741]23855-0.275-0.3249No
94Arl6ip1ADP-ribosylation factor-like 6 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1858943]24045-0.291-0.3276No
95Polr2hpolymerase (RNA) II (DNA directed) polypeptide H [Source:MGI Symbol;Acc:MGI:2384309]24207-0.310-0.3292No
96Gmpr2guanosine monophosphate reductase 2 [Source:MGI Symbol;Acc:MGI:1917903]24360-0.328-0.3302No
97Rfc3replication factor C (activator 1) 3 [Source:MGI Symbol;Acc:MGI:1916513]24464-0.340-0.3296No
98Polr3cpolymerase (RNA) III (DNA directed) polypeptide C [Source:MGI Symbol;Acc:MGI:1921664]24568-0.353-0.3288No
99Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:99830]24820-0.357-0.3328No
100Cdacytidine deaminase [Source:MGI Symbol;Acc:MGI:1919519]25291-0.375-0.3435Yes
101Polr2cpolymerase (RNA) II (DNA directed) polypeptide C [Source:MGI Symbol;Acc:MGI:109299]25382-0.389-0.3419Yes
102Nme1NME/NM23 nucleoside diphosphate kinase 1 [Source:MGI Symbol;Acc:MGI:97355]25405-0.392-0.3381Yes
103Rbx1ring-box 1 [Source:MGI Symbol;Acc:MGI:1891829]25429-0.395-0.3342Yes
104Lig1ligase I, DNA, ATP-dependent [Source:MGI Symbol;Acc:MGI:101789]25483-0.401-0.3313Yes
105Bcap31B cell receptor associated protein 31 [Source:MGI Symbol;Acc:MGI:1350933]25645-0.411-0.3317Yes
106Mrpl40mitochondrial ribosomal protein L40 [Source:MGI Symbol;Acc:MGI:1332635]25770-0.418-0.3308Yes
107Rad52RAD52 homolog, DNA repair protein [Source:MGI Symbol;Acc:MGI:101949]26279-0.477-0.3416Yes
108Polr2epolymerase (RNA) II (DNA directed) polypeptide E [Source:MGI Symbol;Acc:MGI:1913670]26314-0.482-0.3371Yes
109Tsg101tumor susceptibility gene 101 [Source:MGI Symbol;Acc:MGI:106581]26551-0.518-0.3387Yes
110Polr1dpolymerase (RNA) I polypeptide D [Source:MGI Symbol;Acc:MGI:108403]26618-0.527-0.3347Yes
111Ercc8excision repaiross-complementing rodent repair deficiency, complementation group 8 [Source:MGI Symbol;Acc:MGI:1919241]26649-0.531-0.3295Yes
112Xpcxeroderma pigmentosum, complementation group C [Source:MGI Symbol;Acc:MGI:103557]26811-0.558-0.3283Yes
113Pold4polymerase (DNA-directed), delta 4 [Source:MGI Symbol;Acc:MGI:1916995]26868-0.569-0.3235Yes
114Pold3polymerase (DNA-directed), delta 3, accessory subunit [Source:MGI Symbol;Acc:MGI:1915217]26883-0.572-0.3173Yes
115RnmtRNA (guanine-7-) methyltransferase [Source:MGI Symbol;Acc:MGI:1915147]27171-0.621-0.3193Yes
116Taf10TATA-box binding protein associated factor 10 [Source:MGI Symbol;Acc:MGI:1346320]27487-0.667-0.3217Yes
117Cox17cytochrome c oxidase assembly protein 17, copper chaperone [Source:MGI Symbol;Acc:MGI:1333806]27663-0.705-0.3191Yes
118Mpc2mitochondrial pyruvate carrier 2 [Source:MGI Symbol;Acc:MGI:1917706]27757-0.725-0.3137Yes
119Bcambasal cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1929940]28043-0.781-0.3138Yes
120Aaasachalasia, adrenocortical insufficiency, alacrimia [Source:MGI Symbol;Acc:MGI:2443767]28070-0.788-0.3055Yes
121Cant1calcium activated nucleotidase 1 [Source:MGI Symbol;Acc:MGI:1923275]28104-0.795-0.2974Yes
122Gpx4glutathione peroxidase 4 [Source:MGI Symbol;Acc:MGI:104767]28361-0.856-0.2957Yes
123Rfc4replication factor C (activator 1) 4 [Source:MGI Symbol;Acc:MGI:2146571]28415-0.868-0.2873Yes
124Gtf2h5general transcription factor IIH, polypeptide 5 [Source:MGI Symbol;Acc:MGI:107227]28435-0.871-0.2778Yes
125Nelfenegative elongation factor complex member E, Rdbp [Source:MGI Symbol;Acc:MGI:102744]28451-0.876-0.2681Yes
126Hprthypoxanthine guanine phosphoribosyl transferase [Source:MGI Symbol;Acc:MGI:96217]28469-0.879-0.2585Yes
127Taf12TATA-box binding protein associated factor 12 [Source:MGI Symbol;Acc:MGI:1913714]28485-0.883-0.2487Yes
128Polr2gpolymerase (RNA) II (DNA directed) polypeptide G [Source:MGI Symbol;Acc:MGI:1914960]28599-0.914-0.2417Yes
129Polbpolymerase (DNA directed), beta [Source:MGI Symbol;Acc:MGI:97740]28644-0.929-0.2324Yes
130Polr1cpolymerase (RNA) I polypeptide C [Source:MGI Symbol;Acc:MGI:103288]28785-0.965-0.2257Yes
131Polr2kpolymerase (RNA) II (DNA directed) polypeptide K [Source:MGI Symbol;Acc:MGI:102725]29049-1.043-0.2220Yes
132Prim1DNA primase, p49 subunit [Source:MGI Symbol;Acc:MGI:97757]29116-1.065-0.2118Yes
133Nt5c35'-nucleotidase, cytosolic III [Source:MGI Symbol;Acc:MGI:1927186]29125-1.067-0.1997Yes
134Gtf2a2general transcription factor II A, 2 [Source:MGI Symbol;Acc:MGI:1933289]29349-1.138-0.1936Yes
135Tk2thymidine kinase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:1913266]29358-1.142-0.1807Yes
136Ddb2damage specific DNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1355314]29374-1.149-0.1678Yes
137Vps28vacuolar protein sorting 28 [Source:MGI Symbol;Acc:MGI:1914164]29489-1.195-0.1576Yes
138Polr3glpolymerase (RNA) III (DNA directed) polypeptide G like [Source:MGI Symbol;Acc:MGI:1917120]29719-1.290-0.1500Yes
139Rpa3replication protein A3 [Source:MGI Symbol;Acc:MGI:1915490]29811-1.329-0.1375Yes
140Snapc5small nuclear RNA activating complex, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1914282]29864-1.354-0.1235Yes
141Supt4aSPT4A, DSIF elongation factor subunit [Source:MGI Symbol;Acc:MGI:107416]29925-1.386-0.1093Yes
142Dguokdeoxyguanosine kinase [Source:MGI Symbol;Acc:MGI:1351602]29998-1.429-0.0951Yes
143Nme3NME/NM23 nucleoside diphosphate kinase 3 [Source:MGI Symbol;Acc:MGI:1930182]30063-1.465-0.0801Yes
144Rrm2bribonucleotide reductase M2 B (TP53 inducible) [Source:MGI Symbol;Acc:MGI:2155865]30526-1.832-0.0738Yes
145Nt5c5',3'-nucleotidase, cytosolic [Source:MGI Symbol;Acc:MGI:1354954]30602-1.921-0.0539Yes
146MpgN-methylpurine-DNA glycosylase [Source:MGI Symbol;Acc:MGI:97073]30738-2.082-0.0341Yes
147Nme4NME/NM23 nucleoside diphosphate kinase 4 [Source:MGI Symbol;Acc:MGI:1931148]30790-2.157-0.0107Yes
148Guk1guanylate kinase 1 [Source:MGI Symbol;Acc:MGI:95871]30794-2.1620.0143Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_DNA_REPAIR   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_DNA_REPAIR: Random ES distribution   
Gene set null distribution of ES for HALLMARK_DNA_REPAIR