Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_FATTY_ACID_METABOLISM
Enrichment Score (ES)-0.6121449
Normalized Enrichment Score (NES)-1.8944309
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_FATTY_ACID_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Hsph1heat shock 105kDa/110kDa protein 1 [Source:MGI Symbol;Acc:MGI:105053]2821.8090.0058No
2Hsd17b7hydroxysteroid (17-beta) dehydrogenase 7 [Source:MGI Symbol;Acc:MGI:1330808]3661.6850.0171No
3Cratcarnitine acetyltransferase [Source:MGI Symbol;Acc:MGI:109501]10051.2190.0066No
4Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88588]10391.2030.0154No
5Ephx1epoxide hydrolase 1, microsomal [Source:MGI Symbol;Acc:MGI:95405]10541.1940.0248No
6Gpd2glycerol phosphate dehydrogenase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:99778]11881.1480.0300No
7Aqp7aquaporin 7 [Source:MGI Symbol;Acc:MGI:1314647]12401.1260.0377No
8Trp53inp2transformation related protein 53 inducible nuclear protein 2 [Source:MGI Symbol;Acc:MGI:1915978]13291.0940.0438No
9Cpt1acarnitine palmitoyltransferase 1a, liver [Source:MGI Symbol;Acc:MGI:1098296]13361.0910.0526No
10Kmt5alysine methyltransferase 5A [Source:MGI Symbol;Acc:MGI:1915206]17440.9680.0475No
11Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [Source:MGI Symbol;Acc:MGI:109194]21400.8790.0421No
12Pparaperoxisome proliferator activated receptor alpha [Source:MGI Symbol;Acc:MGI:104740]26340.7780.0326No
13Erp29endoplasmic reticulum protein 29 [Source:MGI Symbol;Acc:MGI:1914647]31610.6850.0213No
14Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250]32950.6660.0226No
15Eno2enolase 2, gamma neuronal [Source:MGI Symbol;Acc:MGI:95394]33500.6620.0263No
16Dhcr2424-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1922004]34430.6470.0287No
17Hsd17b11hydroxysteroid (17-beta) dehydrogenase 11 [Source:MGI Symbol;Acc:MGI:2149821]37840.5870.0226No
18Hsd17b4hydroxysteroid (17-beta) dehydrogenase 4 [Source:MGI Symbol;Acc:MGI:105089]39520.5630.0218No
19Sucla2succinate-Coenzyme A ligase, ADP-forming, beta subunit [Source:MGI Symbol;Acc:MGI:1306775]41360.5390.0204No
20Apex1apurinic/apyrimidinic endonuclease 1 [Source:MGI Symbol;Acc:MGI:88042]47790.4820.0037No
21Idh3bisocitrate dehydrogenase 3 (NAD+) beta [Source:MGI Symbol;Acc:MGI:2158650]53030.415-0.0097No
22Hadhbhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Source:MGI Symbol;Acc:MGI:2136381]61430.368-0.0337No
23Odc1ornithine decarboxylase, structural 1 [Source:MGI Symbol;Acc:MGI:97402]64610.333-0.0411No
24Nbnnibrin [Source:MGI Symbol;Acc:MGI:1351625]68620.295-0.0515No
25Metap1methionyl aminopeptidase 1 [Source:MGI Symbol;Acc:MGI:1922874]75470.241-0.0716No
26Mdh2malate dehydrogenase 2, NAD (mitochondrial) [Source:MGI Symbol;Acc:MGI:97050]91330.199-0.1209No
27Bmpr1bbone morphogenetic protein receptor, type 1B [Source:MGI Symbol;Acc:MGI:107191]92540.193-0.1232No
28Rap1gds1RAP1, GTP-GDP dissociation stimulator 1 [Source:MGI Symbol;Acc:MGI:2385189]94750.170-0.1289No
29Mifmacrophage migration inhibitory factor (glycosylation-inhibiting factor) [Source:MGI Symbol;Acc:MGI:96982]97340.138-0.1360No
30Ccdc58coiled-coil domain containing 58 [Source:MGI Symbol;Acc:MGI:2146423]100210.114-0.1443No
31Fmo1flavin containing monooxygenase 1 [Source:MGI Symbol;Acc:MGI:1310002]103260.088-0.1533No
32Lgals1lectin, galactose binding, soluble 1 [Source:MGI Symbol;Acc:MGI:96777]103360.087-0.1529No
33Hpgdhydroxyprostaglandin dehydrogenase 15 (NAD) [Source:MGI Symbol;Acc:MGI:108085]103390.087-0.1523No
34Serinc1serine incorporator 1 [Source:MGI Symbol;Acc:MGI:1926228]103700.084-0.1525No
35Gad2glutamic acid decarboxylase 2 [Source:MGI Symbol;Acc:MGI:95634]108300.037-0.1670No
36Hccsholocytochrome c synthetase [Source:MGI Symbol;Acc:MGI:106911]109570.021-0.1709No
37Acadlacyl-Coenzyme A dehydrogenase, long-chain [Source:MGI Symbol;Acc:MGI:87866]110770.002-0.1747No
38Mgllmonoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042]116600.000-0.1934No
39Tdo2tryptophan 2,3-dioxygenase [Source:MGI Symbol;Acc:MGI:1928486]130570.000-0.2383No
40Fabp1fatty acid binding protein 1, liver [Source:MGI Symbol;Acc:MGI:95479]137070.000-0.2592No
41Celcarboxyl ester lipase [Source:MGI Symbol;Acc:MGI:88374]137560.000-0.2607No
42Hao2hydroxyacid oxidase 2 [Source:MGI Symbol;Acc:MGI:96012]156810.000-0.3226No
43Cd1d2CD1d2 antigen [Source:MGI Symbol;Acc:MGI:107675]170960.000-0.3681No
44Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Source:MGI Symbol;Acc:MGI:101939]185980.000-0.4164No
45Inmtindolethylamine N-methyltransferase [Source:MGI Symbol;Acc:MGI:102963]194260.000-0.4430No
46Car4carbonic anhydrase 4 [Source:MGI Symbol;Acc:MGI:1096574]202410.000-0.4692No
47Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 10 [Source:MGI Symbol;Acc:MGI:88611]202860.000-0.4706No
48NsdhlNAD(P) dependent steroid dehydrogenase-like [Source:MGI Symbol;Acc:MGI:1099438]21050-0.018-0.4950No
49Prdx6peroxiredoxin 6 [Source:MGI Symbol;Acc:MGI:894320]21089-0.023-0.4960No
50Acsl5acyl-CoA synthetase long-chain family member 5 [Source:MGI Symbol;Acc:MGI:1919129]21452-0.064-0.5071No
51Acss1acyl-CoA synthetase short-chain family member 1 [Source:MGI Symbol;Acc:MGI:1915988]21692-0.087-0.5141No
52Acsl1acyl-CoA synthetase long-chain family member 1 [Source:MGI Symbol;Acc:MGI:102797]21702-0.088-0.5137No
53Pcbd1pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 [Source:MGI Symbol;Acc:MGI:94873]21896-0.107-0.5190No
54Pdhbpyruvate dehydrogenase (lipoamide) beta [Source:MGI Symbol;Acc:MGI:1915513]21939-0.112-0.5194No
55Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Source:MGI Symbol;Acc:MGI:1914195]22026-0.119-0.5212No
56Pdha1pyruvate dehydrogenase E1 alpha 1 [Source:MGI Symbol;Acc:MGI:97532]22209-0.141-0.5259No
57Etfdhelectron transferring flavoprotein, dehydrogenase [Source:MGI Symbol;Acc:MGI:106100]22687-0.157-0.5400No
58Idi1isopentenyl-diphosphate delta isomerase [Source:MGI Symbol;Acc:MGI:2442264]22696-0.158-0.5389No
59Aldoaaldolase A, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87994]22747-0.164-0.5392No
60Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A [Source:MGI Symbol;Acc:MGI:1270845]22892-0.176-0.5424No
61Acox1acyl-Coenzyme A oxidase 1, palmitoyl [Source:MGI Symbol;Acc:MGI:1330812]22897-0.177-0.5410No
62Aco2aconitase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:87880]23072-0.199-0.5450No
63Ube2l6ubiquitin-conjugating enzyme E2L 6 [Source:MGI Symbol;Acc:MGI:1914500]23143-0.208-0.5455No
64Acot8acyl-CoA thioesterase 8 [Source:MGI Symbol;Acc:MGI:2158201]23146-0.209-0.5439No
65Sdhcsuccinate dehydrogenase complex, subunit C, integral membrane protein [Source:MGI Symbol;Acc:MGI:1913302]23228-0.219-0.5447No
66Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast) [Source:MGI Symbol;Acc:MGI:1916051]23296-0.226-0.5449No
67Maoamonoamine oxidase A [Source:MGI Symbol;Acc:MGI:96915]23311-0.227-0.5435No
68Rdh1retinol dehydrogenase 1 (all trans) [Source:MGI Symbol;Acc:MGI:1195275]24117-0.300-0.5669No
69Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Source:MGI Symbol;Acc:MGI:107592]24267-0.317-0.5691No
70Idh1isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413]24474-0.341-0.5729No
71Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:1277964]24505-0.347-0.5710No
72Gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source:MGI Symbol;Acc:MGI:95653]24661-0.357-0.5731No
73Gpd1glycerol-3-phosphate dehydrogenase 1 (soluble) [Source:MGI Symbol;Acc:MGI:95679]25173-0.362-0.5865No
74Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Source:MGI Symbol;Acc:MGI:1926170]25373-0.388-0.5897No
75Ltc4sleukotriene C4 synthase [Source:MGI Symbol;Acc:MGI:107498]25696-0.417-0.5967No
76S100a10S100 calcium binding protein A10 (calpactin) [Source:MGI Symbol;Acc:MGI:1339468]26178-0.467-0.6083Yes
77Rdh11retinol dehydrogenase 11 [Source:MGI Symbol;Acc:MGI:102581]26187-0.468-0.6047Yes
78Ncaph2non-SMC condensin II complex, subunit H2 [Source:MGI Symbol;Acc:MGI:1289164]26223-0.473-0.6019Yes
79Fabp2fatty acid binding protein 2, intestinal [Source:MGI Symbol;Acc:MGI:95478]26228-0.474-0.5981Yes
80Acat2acetyl-Coenzyme A acetyltransferase 2 [Source:MGI Symbol;Acc:MGI:87871]26368-0.492-0.5986Yes
81Gabarapl1gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1914980]26488-0.507-0.5982Yes
82Hsdl2hydroxysteroid dehydrogenase like 2 [Source:MGI Symbol;Acc:MGI:1919729]26548-0.517-0.5958Yes
83Ldhalactate dehydrogenase A [Source:MGI Symbol;Acc:MGI:96759]26623-0.528-0.5939Yes
84AuhAU RNA binding protein/enoyl-coenzyme A hydratase [Source:MGI Symbol;Acc:MGI:1338011]26711-0.543-0.5922Yes
85Acsl4acyl-CoA synthetase long-chain family member 4 [Source:MGI Symbol;Acc:MGI:1354713]26722-0.544-0.5880Yes
86H2az1H2A.Z variant histone 1 [Source:MGI Symbol;Acc:MGI:1888388]26898-0.576-0.5889Yes
87Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein [Source:MGI Symbol;Acc:MGI:1914175]27038-0.599-0.5885Yes
88Vnn1vanin 1 [Source:MGI Symbol;Acc:MGI:108395]27168-0.620-0.5875Yes
89Uroduroporphyrinogen decarboxylase [Source:MGI Symbol;Acc:MGI:98916]27360-0.646-0.5883Yes
90Cryzcrystallin, zeta [Source:MGI Symbol;Acc:MGI:88527]27494-0.669-0.5871Yes
91Dlddihydrolipoamide dehydrogenase [Source:MGI Symbol;Acc:MGI:107450]27620-0.699-0.5853Yes
92Idh3gisocitrate dehydrogenase 3 (NAD+), gamma [Source:MGI Symbol;Acc:MGI:1099463]27748-0.724-0.5835Yes
93Suclg2succinate-Coenzyme A ligase, GDP-forming, beta subunit [Source:MGI Symbol;Acc:MGI:1306824]27814-0.733-0.5795Yes
94Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:MGI Symbol;Acc:MGI:87926]27856-0.739-0.5747Yes
95Adipor2adiponectin receptor 2 [Source:MGI Symbol;Acc:MGI:93830]27879-0.745-0.5693Yes
96Aadataminoadipate aminotransferase [Source:MGI Symbol;Acc:MGI:1345167]27904-0.748-0.5639Yes
97Acadsacyl-Coenzyme A dehydrogenase, short chain [Source:MGI Symbol;Acc:MGI:87868]27917-0.750-0.5581Yes
98D2hgdhD-2-hydroxyglutarate dehydrogenase [Source:MGI Symbol;Acc:MGI:2138209]27986-0.769-0.5540Yes
99UgdhUDP-glucose dehydrogenase [Source:MGI Symbol;Acc:MGI:1306785]28002-0.772-0.5481Yes
100Hadhhydroxyacyl-Coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:96009]28113-0.797-0.5451Yes
101Retsatretinol saturase (all trans retinol 13,14 reductase) [Source:MGI Symbol;Acc:MGI:1914692]28114-0.798-0.5385Yes
102Aoc3amine oxidase, copper containing 3 [Source:MGI Symbol;Acc:MGI:1306797]28172-0.810-0.5336Yes
103Sms-psspermine synthase, pseudogene [Source:MGI Symbol;Acc:MGI:3705601]28245-0.829-0.5291Yes
104Acadmacyl-Coenzyme A dehydrogenase, medium chain [Source:MGI Symbol;Acc:MGI:87867]28248-0.829-0.5224Yes
105Blvrabiliverdin reductase A [Source:MGI Symbol;Acc:MGI:88170]28348-0.853-0.5185Yes
106Acaa1aacetyl-Coenzyme A acyltransferase 1A [Source:MGI Symbol;Acc:MGI:2148491]28500-0.888-0.5160Yes
107Eno3enolase 3, beta muscle [Source:MGI Symbol;Acc:MGI:95395]28516-0.893-0.5092Yes
108Eci2enoyl-Coenzyme A delta isomerase 2 [Source:MGI Symbol;Acc:MGI:1346064]28521-0.893-0.5019Yes
109Psme1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [Source:MGI Symbol;Acc:MGI:1096367]28573-0.906-0.4961Yes
110Aladaminolevulinate, delta-, dehydratase [Source:MGI Symbol;Acc:MGI:96853]28677-0.937-0.4917Yes
111Cd36CD36 molecule [Source:MGI Symbol;Acc:MGI:107899]28751-0.957-0.4862Yes
112Bckdhbbranched chain ketoacid dehydrogenase E1, beta polypeptide [Source:MGI Symbol;Acc:MGI:88137]28761-0.958-0.4786Yes
113Me1malic enzyme 1, NADP(+)-dependent, cytosolic [Source:MGI Symbol;Acc:MGI:97043]28808-0.972-0.4720Yes
114Car2carbonic anhydrase 2 [Source:MGI Symbol;Acc:MGI:88269]28961-1.017-0.4685Yes
115Cpt2carnitine palmitoyltransferase 2 [Source:MGI Symbol;Acc:MGI:109176]29065-1.048-0.4632Yes
116Eci1enoyl-Coenzyme A delta isomerase 1 [Source:MGI Symbol;Acc:MGI:94871]29108-1.064-0.4558Yes
117Aldh3a2aldehyde dehydrogenase family 3, subfamily A2 [Source:MGI Symbol;Acc:MGI:1353452]29334-1.134-0.4537Yes
118Suclg1succinate-CoA ligase, GDP-forming, alpha subunit [Source:MGI Symbol;Acc:MGI:1927234]29356-1.142-0.4449Yes
119Aldh9a1aldehyde dehydrogenase 9, subfamily A1 [Source:MGI Symbol;Acc:MGI:1861622]29361-1.145-0.4356Yes
120Nthl1nth (endonuclease III)-like 1 (E.coli) [Source:MGI Symbol;Acc:MGI:1313275]29452-1.182-0.4288Yes
121Adsladenylosuccinate lyase [Source:MGI Symbol;Acc:MGI:103202]29469-1.189-0.4195Yes
122Cpoxcoproporphyrinogen oxidase [Source:MGI Symbol;Acc:MGI:104841]29516-1.206-0.4110Yes
123Fh1fumarate hydratase 1 [Source:MGI Symbol;Acc:MGI:95530]29519-1.209-0.4011Yes
124Gcdhglutaryl-Coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:104541]29607-1.243-0.3937Yes
125Fasnfatty acid synthase [Source:MGI Symbol;Acc:MGI:95485]29614-1.246-0.3836Yes
126Mceemethylmalonyl CoA epimerase [Source:MGI Symbol;Acc:MGI:1920974]29640-1.260-0.3740Yes
127Acaa2acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) [Source:MGI Symbol;Acc:MGI:1098623]29705-1.285-0.3655Yes
128Mdh1malate dehydrogenase 1, NAD (soluble) [Source:MGI Symbol;Acc:MGI:97051]29716-1.290-0.3552Yes
129Ostcoligosaccharyltransferase complex subunit (non-catalytic) [Source:MGI Symbol;Acc:MGI:1913607]29816-1.331-0.3474Yes
130Glulglutamate-ammonia ligase (glutamine synthetase) [Source:MGI Symbol;Acc:MGI:95739]29848-1.346-0.3373Yes
131Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase [Source:MGI Symbol;Acc:MGI:1923792]29856-1.349-0.3264Yes
132Urosuroporphyrinogen III synthase [Source:MGI Symbol;Acc:MGI:98917]29924-1.385-0.3172Yes
133Hsd17b10hydroxysteroid (17-beta) dehydrogenase 10 [Source:MGI Symbol;Acc:MGI:1333871]29972-1.413-0.3070Yes
134Car6carbonic anhydrase 6 [Source:MGI Symbol;Acc:MGI:1333786]30090-1.483-0.2986Yes
135Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase) [Source:MGI Symbol;Acc:MGI:1341859]30139-1.515-0.2876Yes
136Cbr3carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:1309992]30171-1.535-0.2759Yes
137Hmgcl3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Source:MGI Symbol;Acc:MGI:96158]30197-1.554-0.2639Yes
138Ech1enoyl coenzyme A hydratase 1, peroxisomal [Source:MGI Symbol;Acc:MGI:1858208]30334-1.652-0.2547Yes
139Grhprglyoxylate reductase/hydroxypyruvate reductase [Source:MGI Symbol;Acc:MGI:1923488]30381-1.688-0.2423Yes
140Pts6-pyruvoyl-tetrahydropterin synthase [Source:MGI Symbol;Acc:MGI:1338783]30388-1.692-0.2285Yes
141Bphlbiphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) [Source:MGI Symbol;Acc:MGI:1915271]30399-1.699-0.2148Yes
142Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [Source:MGI Symbol;Acc:MGI:2136460]30590-1.904-0.2052Yes
143Slc22a5solute carrier family 22 (organic cation transporter), member 5 [Source:MGI Symbol;Acc:MGI:1329012]30597-1.914-0.1897Yes
144Decr12,4-dienoyl CoA reductase 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1914710]30605-1.924-0.1740Yes
145Acadvlacyl-Coenzyme A dehydrogenase, very long chain [Source:MGI Symbol;Acc:MGI:895149]30679-2.012-0.1598Yes
146Reep6receptor accessory protein 6 [Source:MGI Symbol;Acc:MGI:1917585]30707-2.047-0.1438Yes
147Mlycdmalonyl-CoA decarboxylase [Source:MGI Symbol;Acc:MGI:1928485]30803-2.170-0.1290Yes
148Aldh1a1aldehyde dehydrogenase family 1, subfamily A1 [Source:MGI Symbol;Acc:MGI:1353450]30858-2.263-0.1120Yes
149Acot2acyl-CoA thioesterase 2 [Source:MGI Symbol;Acc:MGI:2159605]30957-2.480-0.0947Yes
150Cbr1carbonyl reductase 1 [Source:MGI Symbol;Acc:MGI:88284]30982-2.536-0.0746Yes
151Aldh3a1aldehyde dehydrogenase family 3, subfamily A1 [Source:MGI Symbol;Acc:MGI:1353451]31130-3.120-0.0536Yes
152Acsm3acyl-CoA synthetase medium-chain family member 3 [Source:MGI Symbol;Acc:MGI:99538]31154-3.363-0.0266Yes
153G0s2G0/G1 switch gene 2 [Source:MGI Symbol;Acc:MGI:1316737]31168-3.5560.0023Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_FATTY_ACID_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_FATTY_ACID_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_FATTY_ACID_METABOLISM