Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_INTERFERON_ALPHA_RESPONSE
Enrichment Score (ES)-0.51534474
Normalized Enrichment Score (NES)-1.5022625
Nominal p-value0.0044247787
FDR q-value0.016563212
FWER p-Value0.146
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INTERFERON_ALPHA_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Csf1colony stimulating factor 1 (macrophage) [Source:MGI Symbol;Acc:MGI:1339753]1022.2730.0270No
2B2mbeta-2 microglobulin [Source:MGI Symbol;Acc:MGI:88127]3471.7080.0419No
3Procrprotein C receptor, endothelial [Source:MGI Symbol;Acc:MGI:104596]4671.5730.0590No
4Ifit2interferon-induced protein with tetratricopeptide repeats 2 [Source:MGI Symbol;Acc:MGI:99449]5211.5190.0775No
5Cxcl10chemokine (C-X-C motif) ligand 10 [Source:MGI Symbol;Acc:MGI:1352450]5571.4900.0963No
6C1s1complement component 1, s subcomponent 1 [Source:MGI Symbol;Acc:MGI:1355312]6451.4230.1124No
7Elf1E74 like ETS transcription factor 1 [Source:MGI Symbol;Acc:MGI:107180]19900.9100.0814No
8Rtp4receptor transporter protein 4 [Source:MGI Symbol;Acc:MGI:1915025]25780.7880.0730No
9Irf9interferon regulatory factor 9 [Source:MGI Symbol;Acc:MGI:107587]35580.6240.0499No
10Ogfropioid growth factor receptor [Source:MGI Symbol;Acc:MGI:1919325]38440.5780.0485No
11Oas1a2'-5' oligoadenylate synthetase 1A [Source:MGI Symbol;Acc:MGI:2180860]38490.5780.0560No
12Sellselectin, lymphocyte [Source:MGI Symbol;Acc:MGI:98279]40380.5530.0573No
13Sp110Sp110 nuclear body protein [Source:MGI Symbol;Acc:MGI:1923364]45620.5120.0474No
14Rnf31ring finger protein 31 [Source:MGI Symbol;Acc:MGI:1934704]46560.4980.0510No
15Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 2 [Source:MGI Symbol;Acc:MGI:1353449]48340.4770.0517No
16Helz2helicase with zinc finger 2, transcriptional coactivator [Source:MGI Symbol;Acc:MGI:2385169]49970.4550.0525No
17Mov10Mov10 RISC complex RNA helicase [Source:MGI Symbol;Acc:MGI:97054]50040.4540.0584No
18Irf2interferon regulatory factor 2 [Source:MGI Symbol;Acc:MGI:96591]50540.4500.0628No
19Lpar6lysophosphatidic acid receptor 6 [Source:MGI Symbol;Acc:MGI:1914418]50710.4480.0682No
20Ifit3interferon-induced protein with tetratricopeptide repeats 3 [Source:MGI Symbol;Acc:MGI:1101055]56820.3870.0538No
21Tmem140transmembrane protein 140 [Source:MGI Symbol;Acc:MGI:1915737]64480.3340.0337No
22Adaradenosine deaminase, RNA-specific [Source:MGI Symbol;Acc:MGI:1889575]65690.3200.0341No
23Cd47CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617]70100.2770.0237No
24Lap3leucine aminopeptidase 3 [Source:MGI Symbol;Acc:MGI:1914238]76870.2270.0050No
25Tent5aterminal nucleotidyltransferase 5A [Source:MGI Symbol;Acc:MGI:2670964]82650.226-0.0105No
26Batf2basic leucine zipper transcription factor, ATF-like 2 [Source:MGI Symbol;Acc:MGI:1921731]100730.109-0.0671No
27Nub1negative regulator of ubiquitin-like proteins 1 [Source:MGI Symbol;Acc:MGI:1889001]104590.077-0.0785No
28Ifi44linterferon-induced protein 44 like [Source:MGI Symbol;Acc:MGI:95975]151480.000-0.2290No
29Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [Source:MGI Symbol;Acc:MGI:1346527]160360.000-0.2574No
30Plscr1phospholipid scramblase 1 [Source:MGI Symbol;Acc:MGI:893575]21020-0.012-0.4173No
31Cmtr1cap methyltransferase 1 [Source:MGI Symbol;Acc:MGI:1921407]21462-0.066-0.4306No
32Lamp3lysosomal-associated membrane protein 3 [Source:MGI Symbol;Acc:MGI:2441659]21519-0.072-0.4314No
33Tdrd7tudor domain containing 7 [Source:MGI Symbol;Acc:MGI:2140279]21649-0.083-0.4344No
34Oasl12'-5' oligoadenylate synthetase-like 1 [Source:MGI Symbol;Acc:MGI:2180849]21652-0.084-0.4334No
35Cxcl11chemokine (C-X-C motif) ligand 11 [Source:MGI Symbol;Acc:MGI:1860203]21714-0.090-0.4341No
36Trafd1TRAF type zinc finger domain containing 1 [Source:MGI Symbol;Acc:MGI:1923551]22097-0.128-0.4447No
37Il4rainterleukin 4 receptor, alpha [Source:MGI Symbol;Acc:MGI:105367]22655-0.151-0.4606No
38Ube2l6ubiquitin-conjugating enzyme E2L 6 [Source:MGI Symbol;Acc:MGI:1914500]23143-0.208-0.4734No
39Slc25a28solute carrier family 25, member 28 [Source:MGI Symbol;Acc:MGI:2180509]23227-0.219-0.4732No
40Casp8caspase 8 [Source:MGI Symbol;Acc:MGI:1261423]23994-0.286-0.4940No
41Ddx60DExD/H box helicase 60 [Source:MGI Symbol;Acc:MGI:2384570]24122-0.300-0.4941No
42Herc6hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1914388]24274-0.318-0.4947No
43Gmprguanosine monophosphate reductase [Source:MGI Symbol;Acc:MGI:1913605]24288-0.319-0.4908No
44Dhx58DEXH (Asp-Glu-X-His) box polypeptide 58 [Source:MGI Symbol;Acc:MGI:1931560]24341-0.325-0.4882No
45Stat2signal transducer and activator of transcription 2 [Source:MGI Symbol;Acc:MGI:103039]24477-0.342-0.4880No
46Ifi44interferon-induced protein 44 [Source:MGI Symbol;Acc:MGI:2443016]24554-0.352-0.4857No
47Ifitm3interferon induced transmembrane protein 3 [Source:MGI Symbol;Acc:MGI:1913391]24679-0.357-0.4849No
48Rsad2radical S-adenosyl methionine domain containing 2 [Source:MGI Symbol;Acc:MGI:1929628]24751-0.357-0.4825No
49Ly6elymphocyte antigen 6 complex, locus E [Source:MGI Symbol;Acc:MGI:106651]24794-0.357-0.4791No
50Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:99830]24820-0.357-0.4751No
51Trim26tripartite motif-containing 26 [Source:MGI Symbol;Acc:MGI:1337056]25256-0.371-0.4841No
52Ifitm1interferon induced transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1915963]25689-0.417-0.4925No
53Bst2bone marrow stromal cell antigen 2 [Source:MGI Symbol;Acc:MGI:1916800]26062-0.454-0.4984No
54Gbp3guanylate binding protein 3 [Source:MGI Symbol;Acc:MGI:1926263]26467-0.504-0.5046No
55Ripk2receptor (TNFRSF)-interacting serine-threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1891456]26802-0.557-0.5079Yes
56Lgals3bplectin, galactoside-binding, soluble, 3 binding protein [Source:MGI Symbol;Acc:MGI:99554]26921-0.580-0.5040Yes
57Parp9poly (ADP-ribose) polymerase family, member 9 [Source:MGI Symbol;Acc:MGI:1933117]26976-0.589-0.4979Yes
58Epsti1epithelial stromal interaction 1 (breast) [Source:MGI Symbol;Acc:MGI:1915168]27322-0.643-0.5004Yes
59Parp12poly (ADP-ribose) polymerase family, member 12 [Source:MGI Symbol;Acc:MGI:2143990]27727-0.721-0.5038Yes
60Trim25tripartite motif-containing 25 [Source:MGI Symbol;Acc:MGI:102749]27836-0.737-0.4974Yes
61Usp18ubiquitin specific peptidase 18 [Source:MGI Symbol;Acc:MGI:1344364]28115-0.798-0.4957Yes
62Isg20interferon-stimulated protein [Source:MGI Symbol;Acc:MGI:1928895]28198-0.814-0.4875Yes
63Casp1caspase 1 [Source:MGI Symbol;Acc:MGI:96544]28283-0.836-0.4791Yes
64Txnipthioredoxin interacting protein [Source:MGI Symbol;Acc:MGI:1889549]28491-0.884-0.4740Yes
65Trim12ctripartite motif-containing 12C [Source:MGI Symbol;Acc:MGI:4821183]28513-0.892-0.4628Yes
66Psma3proteasome subunit alpha 3 [Source:MGI Symbol;Acc:MGI:104883]28515-0.892-0.4509Yes
67Psme1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [Source:MGI Symbol;Acc:MGI:1096367]28573-0.906-0.4407Yes
68Ifitm2interferon induced transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:1933382]28709-0.947-0.4324Yes
69Trim21tripartite motif-containing 21 [Source:MGI Symbol;Acc:MGI:106657]28876-0.989-0.4246Yes
70Irf7interferon regulatory factor 7 [Source:MGI Symbol;Acc:MGI:1859212]28992-1.027-0.4146Yes
71Ifi27interferon, alpha-inducible protein 27 [Source:MGI Symbol;Acc:MGI:1277180]29024-1.034-0.4018Yes
72Mvb12amultivesicular body subunit 12A [Source:MGI Symbol;Acc:MGI:1920961]29146-1.072-0.3914Yes
73Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) [Source:MGI Symbol;Acc:MGI:1346526]29279-1.115-0.3808Yes
74Psme2proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [Source:MGI Symbol;Acc:MGI:1096365]29360-1.144-0.3682Yes
75Ccrl2chemokine (C-C motif) receptor-like 2 [Source:MGI Symbol;Acc:MGI:1920904]29441-1.175-0.3551Yes
76Il15interleukin 15 [Source:MGI Symbol;Acc:MGI:103014]29491-1.197-0.3407Yes
77Il7interleukin 7 [Source:MGI Symbol;Acc:MGI:96561]29532-1.214-0.3258Yes
78Ifih1interferon induced with helicase C domain 1 [Source:MGI Symbol;Acc:MGI:1918836]29534-1.214-0.3097Yes
79Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:MGI Symbol;Acc:MGI:98483]29584-1.232-0.2949Yes
80Ncoa7nuclear receptor coactivator 7 [Source:MGI Symbol;Acc:MGI:2444847]29740-1.300-0.2825Yes
81NmiN-myc (and STAT) interactor [Source:MGI Symbol;Acc:MGI:1928368]29748-1.306-0.2654Yes
82Pnpt1polyribonucleotide nucleotidyltransferase 1 [Source:MGI Symbol;Acc:MGI:1918951]29800-1.323-0.2494Yes
83Trim14tripartite motif-containing 14 [Source:MGI Symbol;Acc:MGI:1921985]29851-1.346-0.2331Yes
84Wars1tryptophanyl-tRNA synthetase1 [Source:MGI Symbol;Acc:MGI:104630]29987-1.424-0.2185Yes
85Uba7ubiquitin-like modifier activating enzyme 7 [Source:MGI Symbol;Acc:MGI:1349462]30045-1.456-0.2009Yes
86Irf1interferon regulatory factor 1 [Source:MGI Symbol;Acc:MGI:96590]30512-1.809-0.1918Yes
87Mx2MX dynamin-like GTPase 2 [Source:MGI Symbol;Acc:MGI:97244]30521-1.817-0.1678Yes
88Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [Source:MGI Symbol;Acc:MGI:96534]30523-1.822-0.1436Yes
89Ifi35interferon-induced protein 35 [Source:MGI Symbol;Acc:MGI:1917360]30730-2.071-0.1227Yes
90Parp14poly (ADP-ribose) polymerase family, member 14 [Source:MGI Symbol;Acc:MGI:1919489]30820-2.194-0.0963Yes
91Samd9lsterile alpha motif domain containing 9-like [Source:MGI Symbol;Acc:MGI:1343184]31014-2.640-0.0674Yes
92Isg15ISG15 ubiquitin-like modifier [Source:MGI Symbol;Acc:MGI:1855694]31058-2.777-0.0318Yes
93Cnp2',3'-cyclic nucleotide 3' phosphodiesterase [Source:MGI Symbol;Acc:MGI:88437]31067-2.8170.0055Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INTERFERON_ALPHA_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INTERFERON_ALPHA_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INTERFERON_ALPHA_RESPONSE