Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_PEROXISOME
Enrichment Score (ES)-0.4470223
Normalized Enrichment Score (NES)-1.3192922
Nominal p-value0.042372882
FDR q-value0.078444295
FWER p-Value0.745
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_PEROXISOME   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Atxn1ataxin 1 [Source:MGI Symbol;Acc:MGI:104783]1522.0920.0258No
2Catcatalase [Source:MGI Symbol;Acc:MGI:88271]2391.8830.0506No
3Cadm1cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1889272]4691.5720.0663No
4Slc23a2solute carrier family 23 (nucleobase transporters), member 2 [Source:MGI Symbol;Acc:MGI:1859682]6101.4430.0830No
5Dio1deiodinase, iodothyronine, type I [Source:MGI Symbol;Acc:MGI:94896]7431.3540.0986No
6Cratcarnitine acetyltransferase [Source:MGI Symbol;Acc:MGI:109501]10051.2190.1081No
7Ctbp1C-terminal binding protein 1 [Source:MGI Symbol;Acc:MGI:1201685]13591.0830.1127No
8Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [Source:MGI Symbol;Acc:MGI:1203524]17070.9770.1158No
9Abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [Source:MGI Symbol;Acc:MGI:1351644]18500.9430.1251No
10Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [Source:MGI Symbol;Acc:MGI:109194]21400.8790.1287No
11Vps4bvacuolar protein sorting 4B [Source:MGI Symbol;Acc:MGI:1100499]26500.7750.1237No
12Ercc1excision repair cross-complementing rodent repair deficiency, complementation group 1 [Source:MGI Symbol;Acc:MGI:95412]29810.7170.1236No
13Dhcr2424-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1922004]34430.6470.1183No
14Abcb9ATP-binding cassette, sub-family B (MDR/TAP), member 9 [Source:MGI Symbol;Acc:MGI:1861729]35030.6350.1257No
15Hsd17b11hydroxysteroid (17-beta) dehydrogenase 11 [Source:MGI Symbol;Acc:MGI:2149821]37840.5870.1254No
16Hsd17b4hydroxysteroid (17-beta) dehydrogenase 4 [Source:MGI Symbol;Acc:MGI:105089]39520.5630.1283No
17Ercc3excision repair cross-complementing rodent repair deficiency, complementation group 3 [Source:MGI Symbol;Acc:MGI:95414]45360.5140.1171No
18Crabp2cellular retinoic acid binding protein II [Source:MGI Symbol;Acc:MGI:88491]56200.3940.0881No
19HrasHarvey rat sarcoma virus oncogene [Source:MGI Symbol;Acc:MGI:96224]61840.3650.0753No
20Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit [Source:MGI Symbol;Acc:MGI:88296]64570.3330.0715No
21Mvpmajor vault protein [Source:MGI Symbol;Acc:MGI:1925638]67310.3010.0671No
22Ctpscytidine 5'-triphosphate synthase [Source:MGI Symbol;Acc:MGI:1858304]69840.2800.0631No
23Sema3csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [Source:MGI Symbol;Acc:MGI:107557]72070.2740.0600No
24Ideinsulin degrading enzyme [Source:MGI Symbol;Acc:MGI:96412]72200.2730.0636No
25Pabpc1poly(A) binding protein, cytoplasmic 1 [Source:MGI Symbol;Acc:MGI:1349722]72460.2710.0668No
26Abcd2ATP-binding cassette, sub-family D (ALD), member 2 [Source:MGI Symbol;Acc:MGI:1349467]73790.2560.0663No
27Gnpatglyceronephosphate O-acyltransferase [Source:MGI Symbol;Acc:MGI:1343460]75940.2380.0630No
28Hsd11b2hydroxysteroid 11-beta dehydrogenase 2 [Source:MGI Symbol;Acc:MGI:104720]95120.1650.0038No
29Pex5peroxisomal biogenesis factor 5 [Source:MGI Symbol;Acc:MGI:1098808]95980.1550.0033No
30Abcb1aATP-binding cassette, sub-family B (MDR/TAP), member 1A [Source:MGI Symbol;Acc:MGI:97570]99900.119-0.0075No
31Fis1fission, mitochondrial 1 [Source:MGI Symbol;Acc:MGI:1913687]104600.077-0.0214No
32Gstk1glutathione S-transferase kappa 1 [Source:MGI Symbol;Acc:MGI:1923513]113550.000-0.0501No
33Slc27a2solute carrier family 27 (fatty acid transporter), member 2 [Source:MGI Symbol;Acc:MGI:1347099]122810.000-0.0798No
34Fabp6fatty acid binding protein 6 [Source:MGI Symbol;Acc:MGI:96565]137080.000-0.1256No
35Celcarboxyl ester lipase [Source:MGI Symbol;Acc:MGI:88374]137560.000-0.1271No
36Scgb1a1secretoglobin, family 1A, member 1 [Source:MGI Symbol;Acc:MGI:98919]143860.000-0.1473No
37Rxrgretinoid X receptor gamma [Source:MGI Symbol;Acc:MGI:98216]144330.000-0.1488No
38Hao2hydroxyacid oxidase 2 [Source:MGI Symbol;Acc:MGI:96012]156810.000-0.1889No
39Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 6 [Source:MGI Symbol;Acc:MGI:88278]161650.000-0.2044No
40Crabp1cellular retinoic acid binding protein I [Source:MGI Symbol;Acc:MGI:88490]187360.000-0.2869No
41Scp2sterol carrier protein 2, liver [Source:MGI Symbol;Acc:MGI:98254]21007-0.010-0.3597No
42Acsl5acyl-CoA synthetase long-chain family member 5 [Source:MGI Symbol;Acc:MGI:1919129]21452-0.064-0.3730No
43Acsl1acyl-CoA synthetase long-chain family member 1 [Source:MGI Symbol;Acc:MGI:102797]21702-0.088-0.3797No
44Sod2superoxide dismutase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:98352]21816-0.099-0.3819No
45Abcd1ATP-binding cassette, sub-family D (ALD), member 1 [Source:MGI Symbol;Acc:MGI:1349215]22080-0.125-0.3885No
46Idi1isopentenyl-diphosphate delta isomerase [Source:MGI Symbol;Acc:MGI:2442264]22696-0.158-0.4059No
47Pex14peroxisomal biogenesis factor 14 [Source:MGI Symbol;Acc:MGI:1927868]22803-0.170-0.4068No
48Acox1acyl-Coenzyme A oxidase 1, palmitoyl [Source:MGI Symbol;Acc:MGI:1330812]22897-0.177-0.4072No
49Abcd3ATP-binding cassette, sub-family D (ALD), member 3 [Source:MGI Symbol;Acc:MGI:1349216]22969-0.187-0.4068No
50Ttrtransthyretin [Source:MGI Symbol;Acc:MGI:98865]23044-0.196-0.4063No
51Acot8acyl-CoA thioesterase 8 [Source:MGI Symbol;Acc:MGI:2158201]23146-0.209-0.4064No
52Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast) [Source:MGI Symbol;Acc:MGI:1916051]23296-0.226-0.4079No
53Pex11aperoxisomal biogenesis factor 11 alpha [Source:MGI Symbol;Acc:MGI:1338788]23319-0.228-0.4053No
54Cdk7cyclin-dependent kinase 7 [Source:MGI Symbol;Acc:MGI:102956]23586-0.250-0.4101No
55Sult2b1sulfotransferase family, cytosolic, 2B, member 1 [Source:MGI Symbol;Acc:MGI:1926342]23804-0.269-0.4132No
56Slc25a4solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [Source:MGI Symbol;Acc:MGI:1353495]24033-0.290-0.4162No
57Bcl10B cell leukemia/lymphoma 10 [Source:MGI Symbol;Acc:MGI:1337994]24056-0.292-0.4127No
58Msh2mutS homolog 2 [Source:MGI Symbol;Acc:MGI:101816]24148-0.302-0.4112No
59Esr2estrogen receptor 2 (beta) [Source:MGI Symbol;Acc:MGI:109392]24402-0.332-0.4144No
60Idh1isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413]24474-0.341-0.4117No
61Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:1277964]24505-0.347-0.4076No
62Cnbpcellular nucleic acid binding protein [Source:MGI Symbol;Acc:MGI:88431]25286-0.374-0.4271No
63Lonp2lon peptidase 2, peroxisomal [Source:MGI Symbol;Acc:MGI:1914137]25624-0.407-0.4320No
64Pex11bperoxisomal biogenesis factor 11 beta [Source:MGI Symbol;Acc:MGI:1338882]26093-0.457-0.4403Yes
65Cln6ceroid-lipofuscinosis, neuronal 6 [Source:MGI Symbol;Acc:MGI:2159324]26176-0.467-0.4361Yes
66Rdh11retinol dehydrogenase 11 [Source:MGI Symbol;Acc:MGI:102581]26187-0.468-0.4296Yes
67Slc25a19solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 [Source:MGI Symbol;Acc:MGI:1914533]26309-0.481-0.4264Yes
68Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [Source:MGI Symbol;Acc:MGI:1352629]26552-0.518-0.4266Yes
69Siah1asiah E3 ubiquitin protein ligase 1A [Source:MGI Symbol;Acc:MGI:108064]26651-0.531-0.4219Yes
70Acsl4acyl-CoA synthetase long-chain family member 4 [Source:MGI Symbol;Acc:MGI:1354713]26722-0.544-0.4162Yes
71Top2atopoisomerase (DNA) II alpha [Source:MGI Symbol;Acc:MGI:98790]27183-0.624-0.4218Yes
72Sod1superoxide dismutase 1, soluble [Source:MGI Symbol;Acc:MGI:98351]27540-0.679-0.4233Yes
73Nr1i2nuclear receptor subfamily 1, group I, member 2 [Source:MGI Symbol;Acc:MGI:1337040]27575-0.688-0.4143Yes
74Tspotranslocator protein [Source:MGI Symbol;Acc:MGI:88222]27708-0.715-0.4081Yes
75Slc35b2solute carrier family 35, member B2 [Source:MGI Symbol;Acc:MGI:1921086]27760-0.725-0.3991Yes
76Dlg4discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959]27945-0.759-0.3938Yes
77Idh2isocitrate dehydrogenase 2 (NADP+), mitochondrial [Source:MGI Symbol;Acc:MGI:96414]27977-0.767-0.3836Yes
78Retsatretinol saturase (all trans retinol 13,14 reductase) [Source:MGI Symbol;Acc:MGI:1914692]28114-0.798-0.3763Yes
79Fdpsfarnesyl diphosphate synthetase [Source:MGI Symbol;Acc:MGI:104888]28227-0.823-0.3678Yes
80Itgb1bp1integrin beta 1 binding protein 1 [Source:MGI Symbol;Acc:MGI:1306802]28234-0.826-0.3559Yes
81Cln8CLN8 transmembrane ER and ERGIC protein [Source:MGI Symbol;Acc:MGI:1349447]28256-0.831-0.3444Yes
82Nudt19nudix hydrolase 19 [Source:MGI Symbol;Acc:MGI:94203]28332-0.847-0.3344Yes
83Acaa1aacetyl-Coenzyme A acyltransferase 1A [Source:MGI Symbol;Acc:MGI:2148491]28500-0.888-0.3267Yes
84Eci2enoyl-Coenzyme A delta isomerase 2 [Source:MGI Symbol;Acc:MGI:1346064]28521-0.893-0.3142Yes
85Fads1fatty acid desaturase 1 [Source:MGI Symbol;Acc:MGI:1923517]28716-0.948-0.3066Yes
86Slc25a17solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 [Source:MGI Symbol;Acc:MGI:1342248]28845-0.981-0.2963Yes
87Prdx5peroxiredoxin 5 [Source:MGI Symbol;Acc:MGI:1859821]28886-0.991-0.2830Yes
88Pex2peroxisomal biogenesis factor 2 [Source:MGI Symbol;Acc:MGI:107486]29124-1.067-0.2750Yes
89Prdx1peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]29206-1.092-0.2616Yes
90Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:MGI Symbol;Acc:MGI:2141879]29304-1.124-0.2482Yes
91Aldh9a1aldehyde dehydrogenase 9, subfamily A1 [Source:MGI Symbol;Acc:MGI:1861622]29361-1.145-0.2332Yes
92Pex6peroxisomal biogenesis factor 6 [Source:MGI Symbol;Acc:MGI:2385054]29616-1.246-0.2231Yes
93Ephx2epoxide hydrolase 2, cytoplasmic [Source:MGI Symbol;Acc:MGI:99500]29991-1.425-0.2142Yes
94Pex13peroxisomal biogenesis factor 13 [Source:MGI Symbol;Acc:MGI:1919379]30113-1.499-0.1961Yes
95Hmgcl3-hydroxy-3-methylglutaryl-Coenzyme A lyase [Source:MGI Symbol;Acc:MGI:96158]30197-1.554-0.1760Yes
96Ech1enoyl coenzyme A hydratase 1, peroxisomal [Source:MGI Symbol;Acc:MGI:1858208]30334-1.652-0.1561Yes
97Albalbumin [Source:MGI Symbol;Acc:MGI:87991]30380-1.688-0.1328Yes
98Dhrs3dehydrogenase/reductase (SDR family) member 3 [Source:MGI Symbol;Acc:MGI:1315215]30503-1.804-0.1103Yes
99Mlycdmalonyl-CoA decarboxylase [Source:MGI Symbol;Acc:MGI:1928485]30803-2.170-0.0881Yes
100Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569]30817-2.191-0.0564Yes
101Aldh1a1aldehyde dehydrogenase family 1, subfamily A1 [Source:MGI Symbol;Acc:MGI:1353450]30858-2.263-0.0245Yes
102Isoc1isochorismatase domain containing 1 [Source:MGI Symbol;Acc:MGI:1913557]30967-2.5000.0087Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_PEROXISOME   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_PEROXISOME: Random ES distribution   
Gene set null distribution of ES for HALLMARK_PEROXISOME