Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_SPERMATOGENESIS
Enrichment Score (ES)0.317417
Normalized Enrichment Score (NES)1.0766938
Nominal p-value0.24731183
FDR q-value0.3286495
FWER p-Value0.97
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_SPERMATOGENESIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Tle4transducin-like enhancer of split 4 [Source:MGI Symbol;Acc:MGI:104633]5291.5150.0085Yes
2Nek2NIMA (never in mitosis gene a)-related expressed kinase 2 [Source:MGI Symbol;Acc:MGI:109359]6981.3800.0264Yes
3Hspa4lheat shock protein 4 like [Source:MGI Symbol;Acc:MGI:107422]7381.3580.0480Yes
4Ncaphnon-SMC condensin I complex, subunit H [Source:MGI Symbol;Acc:MGI:2444777]7601.3420.0700Yes
5Bub1BUB1, mitotic checkpoint serine/threonine kinase [Source:MGI Symbol;Acc:MGI:1100510]11281.1660.0779Yes
6PacrgPARK2 co-regulated [Source:MGI Symbol;Acc:MGI:1916560]13331.0920.0897Yes
7Stam2signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [Source:MGI Symbol;Acc:MGI:1929100]13431.0890.1078Yes
8Dbf4DBF4 zinc finger [Source:MGI Symbol;Acc:MGI:1351328]13961.0690.1241Yes
9Zc2hc1czinc finger, C2HC-type containing 1C [Source:MGI Symbol;Acc:MGI:1919600]16121.0010.1341Yes
10Tktl1transketolase-like 1 [Source:MGI Symbol;Acc:MGI:1933244]17090.9770.1475Yes
11Gsg1germ cell associated 1 [Source:MGI Symbol;Acc:MGI:1194499]17110.9760.1639Yes
12Chrm4cholinergic receptor, muscarinic 4 [Source:MGI Symbol;Acc:MGI:88399]17940.9570.1774Yes
13Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha [Source:MGI Symbol;Acc:MGI:108025]18180.9500.1927Yes
14TtkTtk protein kinase [Source:MGI Symbol;Acc:MGI:1194921]18650.9410.2071Yes
15Papolbpoly (A) polymerase beta (testis specific) [Source:MGI Symbol;Acc:MGI:1932115]22960.8480.2076Yes
16Ip6k1inositol hexaphosphate kinase 1 [Source:MGI Symbol;Acc:MGI:1351633]24810.8090.2153Yes
17Mllt10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [Source:MGI Symbol;Acc:MGI:1329038]26700.7710.2223Yes
18Hspa1lheat shock protein 1-like [Source:MGI Symbol;Acc:MGI:96231]28470.7410.2291Yes
19Strbpspermatid perinuclear RNA binding protein [Source:MGI Symbol;Acc:MGI:104626]28600.7380.2412Yes
20Slc2a5solute carrier family 2 (facilitated glucose transporter), member 5 [Source:MGI Symbol;Acc:MGI:1928369]28970.7320.2523Yes
21Slc12a2solute carrier family 12, member 2 [Source:MGI Symbol;Acc:MGI:101924]30460.7030.2594Yes
22Scg5secretogranin V [Source:MGI Symbol;Acc:MGI:98289]32040.6810.2659Yes
23Kif2ckinesin family member 2C [Source:MGI Symbol;Acc:MGI:1921054]32520.6750.2757Yes
24Mast2microtubule associated serine/threonine kinase 2 [Source:MGI Symbol;Acc:MGI:894676]33790.6580.2828Yes
25Tcp11t-complex protein 11 [Source:MGI Symbol;Acc:MGI:98544]35470.6260.2880Yes
26Nos1nitric oxide synthase 1, neuronal [Source:MGI Symbol;Acc:MGI:97360]42460.5260.2744Yes
27Actl7bactin-like 7b [Source:MGI Symbol;Acc:MGI:1343053]43420.5230.2802Yes
28Gpr182G protein-coupled receptor 182 [Source:MGI Symbol;Acc:MGI:109545]43940.5230.2873Yes
29Septin4septin 4 [Source:MGI Symbol;Acc:MGI:1270156]45420.5140.2913Yes
30Art3ADP-ribosyltransferase 3 [Source:MGI Symbol;Acc:MGI:1202729]45890.5070.2983Yes
31Dmrt1doublesex and mab-3 related transcription factor 1 [Source:MGI Symbol;Acc:MGI:1354733]46430.5000.3051Yes
32Agfg1ArfGAP with FG repeats 1 [Source:MGI Symbol;Acc:MGI:1333754]46550.4980.3131Yes
33Tsntranslin [Source:MGI Symbol;Acc:MGI:109263]49400.4630.3118Yes
34Chfrcheckpoint with forkhead and ring finger domains [Source:MGI Symbol;Acc:MGI:2444898]50800.4470.3149Yes
35Topbp1topoisomerase (DNA) II binding protein 1 [Source:MGI Symbol;Acc:MGI:1920018]52250.4270.3174Yes
36Nf2neurofibromin 2 [Source:MGI Symbol;Acc:MGI:97307]54380.3990.3173No
37Ezh2enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:MGI Symbol;Acc:MGI:107940]61730.3660.2999No
38Oaz3ornithine decarboxylase antizyme 3 [Source:MGI Symbol;Acc:MGI:1858170]67230.3020.2874No
39Tnni3troponin I, cardiac 3 [Source:MGI Symbol;Acc:MGI:98783]67500.3010.2916No
40Arl4aADP-ribosylation factor-like 4A [Source:MGI Symbol;Acc:MGI:99437]68660.2950.2929No
41Ideinsulin degrading enzyme [Source:MGI Symbol;Acc:MGI:96412]72200.2730.2861No
42Clvs1clavesin 1 [Source:MGI Symbol;Acc:MGI:1921688]73030.2650.2880No
43Aurkaaurora kinase A [Source:MGI Symbol;Acc:MGI:894678]76150.2360.2819No
44Pomcpro-opiomelanocortin-alpha [Source:MGI Symbol;Acc:MGI:97742]77610.2260.2811No
45Clgncalmegin [Source:MGI Symbol;Acc:MGI:107472]78140.2260.2832No
46Jam3junction adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1933825]78570.2260.2857No
47Adcyap1adenylate cyclase activating polypeptide 1 [Source:MGI Symbol;Acc:MGI:105094]79050.2260.2880No
48H1f6H1.6 linker histone, cluster member [Source:MGI Symbol;Acc:MGI:1888530]82550.2260.2806No
49Elovl3elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 [Source:MGI Symbol;Acc:MGI:1195976]88350.2260.2658No
50Mlf1myeloid leukemia factor 1 [Source:MGI Symbol;Acc:MGI:1341819]89890.2160.2645No
51Cdkn3cyclin-dependent kinase inhibitor 3 [Source:MGI Symbol;Acc:MGI:1919641]90300.2110.2667No
52Adam2a disintegrin and metallopeptidase domain 2 [Source:MGI Symbol;Acc:MGI:1340894]90580.2070.2694No
53Cnih2cornichon family AMPA receptor auxiliary protein 2 [Source:MGI Symbol;Acc:MGI:1277225]91090.2020.2712No
54Csnk2a2casein kinase 2, alpha prime polypeptide [Source:MGI Symbol;Acc:MGI:88547]93020.1880.2682No
55Ybx2Y box protein 2 [Source:MGI Symbol;Acc:MGI:1096372]94960.1670.2648No
56Snap91synaptosomal-associated protein 91 [Source:MGI Symbol;Acc:MGI:109132]97430.1370.2592No
57Ddx4DEAD box helicase 4 [Source:MGI Symbol;Acc:MGI:102670]97760.1330.2604No
58Tekt2tektin 2 [Source:MGI Symbol;Acc:MGI:1346335]98740.1230.2593No
59Alox15arachidonate 15-lipoxygenase [Source:MGI Symbol;Acc:MGI:87997]99080.1230.2603No
60Pias2protein inhibitor of activated STAT 2 [Source:MGI Symbol;Acc:MGI:1096566]102140.1000.2522No
61Il13ra2interleukin 13 receptor, alpha 2 [Source:MGI Symbol;Acc:MGI:1277954]102910.0930.2514No
62Dccdeleted in colorectal carcinoma [Source:MGI Symbol;Acc:MGI:94869]104560.0770.2474No
63Nphp1nephronophthisis 1 (juvenile) homolog (human) [Source:MGI Symbol;Acc:MGI:1858233]109430.0230.2321No
64Rad17RAD17 checkpoint clamp loader component [Source:MGI Symbol;Acc:MGI:1333807]110310.0090.2295No
65Dmc1DNA meiotic recombinase 1 [Source:MGI Symbol;Acc:MGI:105393]115890.0000.2116No
66Zpbpzona pellucida binding protein [Source:MGI Symbol;Acc:MGI:1855701]120800.0000.1958No
67Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex [Source:MGI Symbol;Acc:MGI:96019]121940.0000.1922No
68Dpep3dipeptidase 3 [Source:MGI Symbol;Acc:MGI:1919104]130090.0000.1660No
69Htr5a5-hydroxytryptamine (serotonin) receptor 5A [Source:MGI Symbol;Acc:MGI:96283]140880.0000.1314No
70Ldhclactate dehydrogenase C [Source:MGI Symbol;Acc:MGI:96764]141640.0000.1290No
71Akap4A kinase (PRKA) anchor protein 4 [Source:MGI Symbol;Acc:MGI:102794]144080.0000.1212No
72Rpl39lribosomal protein L39-like [Source:MGI Symbol;Acc:MGI:1915422]145050.0000.1181No
73Sycp1synaptonemal complex protein 1 [Source:MGI Symbol;Acc:MGI:105931]151420.0000.0976No
74Dnajb8DnaJ heat shock protein family (Hsp40) member B8 [Source:MGI Symbol;Acc:MGI:1922801]154820.0000.0867No
75Cst8cystatin 8 (cystatin-related epididymal spermatogenic) [Source:MGI Symbol;Acc:MGI:107161]156260.0000.0821No
76Scg3secretogranin III [Source:MGI Symbol;Acc:MGI:103032]159600.0000.0714No
77Pdha2pyruvate dehydrogenase E1 alpha 2 [Source:MGI Symbol;Acc:MGI:97533]168150.0000.0440No
78Odf1outer dense fiber of sperm tails 1 [Source:MGI Symbol;Acc:MGI:97424]174620.0000.0232No
79Gad1glutamate decarboxylase 1 [Source:MGI Symbol;Acc:MGI:95632]183930.000-0.0067No
80Thegtesticular haploid expressed gene [Source:MGI Symbol;Acc:MGI:1338756]185080.000-0.0104No
81Ccna1cyclin A1 [Source:MGI Symbol;Acc:MGI:108042]191760.000-0.0318No
82Crisp2cysteine-rich secretory protein 2 [Source:MGI Symbol;Acc:MGI:98815]194490.000-0.0406No
83Tnp2transition protein 2 [Source:MGI Symbol;Acc:MGI:98785]194610.000-0.0409No
84Tnp1transition protein 1 [Source:MGI Symbol;Acc:MGI:98784]194620.000-0.0409No
85Hoxb1homeobox B1 [Source:MGI Symbol;Acc:MGI:96182]198460.000-0.0532No
86Adad1adenosine deaminase domain containing 1 (testis specific) [Source:MGI Symbol;Acc:MGI:103258]199100.000-0.0552No
87Camk4calcium/calmodulin-dependent protein kinase IV [Source:MGI Symbol;Acc:MGI:88258]199150.000-0.0554No
88Il12rb2interleukin 12 receptor, beta 2 [Source:MGI Symbol;Acc:MGI:1270861]200720.000-0.0604No
89Pgk2phosphoglycerate kinase 2 [Source:MGI Symbol;Acc:MGI:97563]201720.000-0.0636No
90Znrf4zinc and ring finger 4 [Source:MGI Symbol;Acc:MGI:1341258]207710.000-0.0828No
91Nefhneurofilament, heavy polypeptide [Source:MGI Symbol;Acc:MGI:97309]208800.000-0.0863No
92Pcsk4proprotein convertase subtilisin/kexin type 4 [Source:MGI Symbol;Acc:MGI:97514]21265-0.044-0.0979No
93Mtormechanistic target of rapamycin kinase [Source:MGI Symbol;Acc:MGI:1928394]21285-0.046-0.0977No
94Pebp1phosphatidylethanolamine binding protein 1 [Source:MGI Symbol;Acc:MGI:1344408]21622-0.081-0.1071No
95Spata6spermatogenesis associated 6 [Source:MGI Symbol;Acc:MGI:1915196]21729-0.092-0.1090No
96Mtnr1amelatonin receptor 1A [Source:MGI Symbol;Acc:MGI:102967]22282-0.146-0.1243No
97Prm2protamine 2 [Source:MGI Symbol;Acc:MGI:97766]22300-0.146-0.1224No
98Naa11N(alpha)-acetyltransferase 11, NatA catalytic subunit [Source:MGI Symbol;Acc:MGI:2141314]22515-0.146-0.1268No
99Tssk2testis-specific serine kinase 2 [Source:MGI Symbol;Acc:MGI:1347559]22525-0.146-0.1246No
100Cdk1cyclin-dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351]22767-0.167-0.1295No
101Acrbpproacrosin binding protein [Source:MGI Symbol;Acc:MGI:1859515]22790-0.168-0.1274No
102Hspa2heat shock protein 2 [Source:MGI Symbol;Acc:MGI:96243]22925-0.180-0.1287No
103Acrv1acrosomal vesicle protein 1 [Source:MGI Symbol;Acc:MGI:104590]22962-0.186-0.1267No
104Parp2poly (ADP-ribose) polymerase family, member 2 [Source:MGI Symbol;Acc:MGI:1341112]23107-0.204-0.1279No
105Ift88intraflagellar transport 88 [Source:MGI Symbol;Acc:MGI:98715]23130-0.207-0.1251No
106Sirt1sirtuin 1 [Source:MGI Symbol;Acc:MGI:2135607]23223-0.218-0.1244No
107Zc3h14zinc finger CCCH type containing 14 [Source:MGI Symbol;Acc:MGI:1919824]23541-0.246-0.1304No
108ClpbClpB caseinolytic peptidase B [Source:MGI Symbol;Acc:MGI:1100517]23692-0.257-0.1309No
109Ddx25DEAD box helicase 25 [Source:MGI Symbol;Acc:MGI:1353582]23892-0.277-0.1326No
110Vdac3voltage-dependent anion channel 3 [Source:MGI Symbol;Acc:MGI:106922]24280-0.318-0.1397No
111Gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source:MGI Symbol;Acc:MGI:95653]24661-0.357-0.1459No
112Shesrc homology 2 domain-containing transforming protein E [Source:MGI Symbol;Acc:MGI:1099462]25281-0.373-0.1595No
113Grm8glutamate receptor, metabotropic 8 [Source:MGI Symbol;Acc:MGI:1351345]25595-0.403-0.1628No
114Phkg2phosphorylase kinase, gamma 2 (testis) [Source:MGI Symbol;Acc:MGI:1916211]25671-0.416-0.1582No
115Gmcl1germ cell-less, spermatogenesis associated 1 [Source:MGI Symbol;Acc:MGI:1345156]25771-0.418-0.1543No
116Taldo1transaldolase 1 [Source:MGI Symbol;Acc:MGI:1274789]25783-0.420-0.1476No
117Gstm5glutathione S-transferase, mu 5 [Source:MGI Symbol;Acc:MGI:1309466]25947-0.438-0.1455No
118Mep1bmeprin 1 beta [Source:MGI Symbol;Acc:MGI:96964]26083-0.456-0.1421No
119Npy5rneuropeptide Y receptor Y5 [Source:MGI Symbol;Acc:MGI:108082]26400-0.495-0.1439No
120Gfi1growth factor independent 1 transcription repressor [Source:MGI Symbol;Acc:MGI:103170]26714-0.543-0.1448No
121Phf7PHD finger protein 7 [Source:MGI Symbol;Acc:MGI:1919088]26872-0.570-0.1403No
122Pgs1phosphatidylglycerophosphate synthase 1 [Source:MGI Symbol;Acc:MGI:1921701]26878-0.571-0.1308No
123BrafBraf transforming gene [Source:MGI Symbol;Acc:MGI:88190]27408-0.649-0.1369No
124Tuba3atubulin, alpha 3A [Source:MGI Symbol;Acc:MGI:1095406]27797-0.732-0.1370No
125Tulp2tubby-like protein 2 [Source:MGI Symbol;Acc:MGI:1861600]28236-0.827-0.1371No
126Rfc4replication factor C (activator 1) 4 [Source:MGI Symbol;Acc:MGI:2146571]28415-0.868-0.1282No
127Coilcoilin [Source:MGI Symbol;Acc:MGI:104842]28418-0.869-0.1136No
128Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Source:MGI Symbol;Acc:MGI:87874]28548-0.900-0.1026No
129Ccnb2cyclin B2 [Source:MGI Symbol;Acc:MGI:88311]28561-0.903-0.0878No
130Psmg1proteasome (prosome, macropain) assembly chaperone 1 [Source:MGI Symbol;Acc:MGI:1860263]29070-1.049-0.0864No
131Cct6bchaperonin containing Tcp1, subunit 6b (zeta) [Source:MGI Symbol;Acc:MGI:1329013]29400-1.161-0.0774No
132Lpin1lipin 1 [Source:MGI Symbol;Acc:MGI:1891340]29679-1.272-0.0649No
133Pcsk1nproprotein convertase subtilisin/kexin type 1 inhibitor [Source:MGI Symbol;Acc:MGI:1353431]29938-1.394-0.0497No
134Map7microtubule-associated protein 7 [Source:MGI Symbol;Acc:MGI:1328328]30684-2.018-0.0396No
135Cftrcystic fibrosis transmembrane conductance regulator [Source:MGI Symbol;Acc:MGI:88388]31160-3.4030.0025No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_SPERMATOGENESIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_SPERMATOGENESIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_SPERMATOGENESIS