Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_TGF_BETA_SIGNALING
Enrichment Score (ES)0.63041747
Normalized Enrichment Score (NES)1.8566718
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_TGF_BETA_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Pmepa1prostate transmembrane protein, androgen induced 1 [Source:MGI Symbol;Acc:MGI:1929600]662.4830.0548Yes
2Engendoglin [Source:MGI Symbol;Acc:MGI:95392]1612.0800.0995Yes
3Furinfurin (paired basic amino acid cleaving enzyme) [Source:MGI Symbol;Acc:MGI:97513]2381.8840.1402Yes
4Slc20a1solute carrier family 20, member 1 [Source:MGI Symbol;Acc:MGI:108392]3131.7460.1778Yes
5Acvr1activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911]3171.7430.2177Yes
6Bmpr2bone morphogenetic protein receptor, type II (serine/threonine kinase) [Source:MGI Symbol;Acc:MGI:1095407]3581.6920.2552Yes
7Smad7SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518]4291.6200.2901Yes
8Skiski sarcoma viral oncogene homolog (avian) [Source:MGI Symbol;Acc:MGI:98310]4721.5690.3247Yes
9Thbs1thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737]5631.4880.3559Yes
10Ncor2nuclear receptor co-repressor 2 [Source:MGI Symbol;Acc:MGI:1337080]9461.2470.3722Yes
11ApcAPC, WNT signaling pathway regulator [Source:MGI Symbol;Acc:MGI:88039]9561.2450.4005Yes
12Smad6SMAD family member 6 [Source:MGI Symbol;Acc:MGI:1336883]9991.2220.4271Yes
13Rab31RAB31, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1914603]10711.1890.4521Yes
14Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 1 [Source:MGI Symbol;Acc:MGI:97608]12011.1420.4741Yes
15Smurf1SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038]13931.0710.4925Yes
16Hipk2homeodomain interacting protein kinase 2 [Source:MGI Symbol;Acc:MGI:1314872]14381.0560.5153Yes
17Bmpr1abone morphogenetic protein receptor, type 1A [Source:MGI Symbol;Acc:MGI:1338938]16700.9860.5305Yes
18Tgfbr1transforming growth factor, beta receptor I [Source:MGI Symbol;Acc:MGI:98728]17590.9640.5498Yes
19Bcar3breast cancer anti-estrogen resistance 3 [Source:MGI Symbol;Acc:MGI:1352501]19680.9130.5640Yes
20Fkbp1aFK506 binding protein 1a [Source:MGI Symbol;Acc:MGI:95541]19910.9090.5842Yes
21Tgfb1transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]22640.8540.5950Yes
22SkilSKI-like [Source:MGI Symbol;Acc:MGI:106203]24900.8070.6063Yes
23Arid4bAT rich interactive domain 4B (RBP1-like) [Source:MGI Symbol;Acc:MGI:2137512]30280.7080.6053Yes
24Ctnnb1catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]30730.6980.6199Yes
25Cdk9cyclin-dependent kinase 9 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1328368]32310.6780.6304Yes
26Id1inhibitor of DNA binding 1, HLH protein [Source:MGI Symbol;Acc:MGI:96396]42190.5290.6109No
27Klf10Kruppel-like factor 10 [Source:MGI Symbol;Acc:MGI:1101353]52910.4170.5861No
28Map3k7mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877]54050.4040.5917No
29XiapX-linked inhibitor of apoptosis [Source:MGI Symbol;Acc:MGI:107572]62850.3530.5716No
30Id3inhibitor of DNA binding 3 [Source:MGI Symbol;Acc:MGI:96398]63890.3400.5761No
31Smad1SMAD family member 1 [Source:MGI Symbol;Acc:MGI:109452]66350.3110.5754No
32Wwtr1WW domain containing transcription regulator 1 [Source:MGI Symbol;Acc:MGI:1917649]72300.2720.5626No
33Trim33tripartite motif-containing 33 [Source:MGI Symbol;Acc:MGI:2137357]89230.2220.5134No
34Ifngr2interferon gamma receptor 2 [Source:MGI Symbol;Acc:MGI:107654]92240.1960.5083No
35Rhoaras homolog family member A [Source:MGI Symbol;Acc:MGI:1096342]95240.1630.5024No
36Junbjun B proto-oncogene [Source:MGI Symbol;Acc:MGI:96647]96910.1440.5004No
37Smad3SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674]102200.0990.4858No
38Nognoggin [Source:MGI Symbol;Acc:MGI:104327]156060.0000.3131No
39Cdkn1ccyclin-dependent kinase inhibitor 1C (P57) [Source:MGI Symbol;Acc:MGI:104564]169650.0000.2695No
40Sptbn1spectrin beta, non-erythrocytic 1 [Source:MGI Symbol;Acc:MGI:98388]21779-0.0950.1174No
41Tjp1tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759]22991-0.1900.0829No
42Ltbp2latent transforming growth factor beta binding protein 2 [Source:MGI Symbol;Acc:MGI:99502]23093-0.2020.0843No
43Hdac1histone deacetylase 1 [Source:MGI Symbol;Acc:MGI:108086]24228-0.3120.0551No
44Ube2d3ubiquitin-conjugating enzyme E2D 3 [Source:MGI Symbol;Acc:MGI:1913355]25203-0.3650.0322No
45Tgif1TGFB-induced factor homeobox 1 [Source:MGI Symbol;Acc:MGI:1194497]26810-0.557-0.0065No
46Smurf2SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563]26842-0.5620.0054No
47Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform [Source:MGI Symbol;Acc:MGI:99878]26853-0.5660.0180No
48Fntafarnesyltransferase, CAAX box, alpha [Source:MGI Symbol;Acc:MGI:104683]26978-0.5890.0275No
49Cdh1cadherin 1 [Source:MGI Symbol;Acc:MGI:88354]27037-0.5980.0394No
50Bmp2bone morphogenetic protein 2 [Source:MGI Symbol;Acc:MGI:88177]27614-0.6970.0369No
51Ppp1caprotein phosphatase 1 catalytic subunit alpha [Source:MGI Symbol;Acc:MGI:103016]28508-0.8900.0287No
52Ppp1r15aprotein phosphatase 1, regulatory subunit 15A [Source:MGI Symbol;Acc:MGI:1927072]28967-1.0200.0374No
53Id2inhibitor of DNA binding 2 [Source:MGI Symbol;Acc:MGI:96397]30185-1.5460.0338No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_TGF_BETA_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_TGF_BETA_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_TGF_BETA_SIGNALING