Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classSCR
GeneSetHALLMARK_UNFOLDED_PROTEIN_RESPONSE
Enrichment Score (ES)-0.5525847
Normalized Enrichment Score (NES)-1.6571366
Nominal p-value0.0
FDR q-value0.0034961
FWER p-Value0.02
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_UNFOLDED_PROTEIN_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Eif4g1eukaryotic translation initiation factor 4, gamma 1 [Source:MGI Symbol;Acc:MGI:2384784]6521.417-0.0057No
2Calrcalreticulin [Source:MGI Symbol;Acc:MGI:88252]9881.226-0.0032No
3Bag3BCL2-associated athanogene 3 [Source:MGI Symbol;Acc:MGI:1352493]10801.1830.0066No
4Dnajc3DnaJ heat shock protein family (Hsp40) member C3 [Source:MGI Symbol;Acc:MGI:107373]13321.0920.0103No
5Cxxc1CXXC finger 1 (PHD domain) [Source:MGI Symbol;Acc:MGI:1921572]13421.0900.0218No
6Nolc1nucleolar and coiled-body phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:1918019]15241.0260.0270No
7Tatdn2TatD DNase domain containing 2 [Source:MGI Symbol;Acc:MGI:3576210]16860.9820.0324No
8Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D1 [Source:MGI Symbol;Acc:MGI:1201778]20100.9030.0318No
9Dcp1adecapping mRNA 1A [Source:MGI Symbol;Acc:MGI:1923151]21810.8700.0357No
10Eif2ak3eukaryotic translation initiation factor 2 alpha kinase 3 [Source:MGI Symbol;Acc:MGI:1341830]23890.8290.0380No
11Arfgap1ADP-ribosylation factor GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:2183559]27630.7560.0341No
12Hsp90b1heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817]29400.7240.0363No
13Hspa5heat shock protein 5 [Source:MGI Symbol;Acc:MGI:95835]30420.7040.0406No
14Dcp2decapping mRNA 2 [Source:MGI Symbol;Acc:MGI:1917890]30640.7000.0475No
15Hyou1hypoxia up-regulated 1 [Source:MGI Symbol;Acc:MGI:108030]30690.6990.0549No
16Dnaja4DnaJ heat shock protein family (Hsp40) member A4 [Source:MGI Symbol;Acc:MGI:1927638]31200.6900.0607No
17Exosc2exosome component 2 [Source:MGI Symbol;Acc:MGI:2385133]31660.6850.0666No
18Kif5bkinesin family member 5B [Source:MGI Symbol;Acc:MGI:1098268]32650.6700.0707No
19Dkc1dyskeratosis congenita 1, dyskerin [Source:MGI Symbol;Acc:MGI:1861727]36850.6050.0638No
20Nfyanuclear transcription factor-Y alpha [Source:MGI Symbol;Acc:MGI:97316]38310.5800.0654No
21Cnot2CCR4-NOT transcription complex, subunit 2 [Source:MGI Symbol;Acc:MGI:1919318]39230.5670.0685No
22Cnot4CCR4-NOT transcription complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1859026]42660.5230.0632No
23Fusfused in sarcoma [Source:MGI Symbol;Acc:MGI:1353633]44920.5180.0615No
24H2axH2A.X variant histone [Source:MGI Symbol;Acc:MGI:102688]45810.5080.0642No
25Exosc10exosome component 10 [Source:MGI Symbol;Acc:MGI:1355322]48210.4770.0616No
26Sdad1SDA1 domain containing 1 [Source:MGI Symbol;Acc:MGI:2140779]49390.4630.0629No
27KhsrpKH-type splicing regulatory protein [Source:MGI Symbol;Acc:MGI:1336214]51080.4440.0623No
28MtrexMtr4 exosome RNA helicase [Source:MGI Symbol;Acc:MGI:1919448]52970.4160.0607No
29Prebprolactin regulatory element binding [Source:MGI Symbol;Acc:MGI:1355326]60890.3730.0393No
30Dctn1dynactin 1 [Source:MGI Symbol;Acc:MGI:107745]62090.3620.0394No
31Edc4enhancer of mRNA decapping 4 [Source:MGI Symbol;Acc:MGI:2446249]62120.3620.0432No
32Paip1polyadenylate binding protein-interacting protein 1 [Source:MGI Symbol;Acc:MGI:2384993]65120.3260.0371No
33Zbtb17zinc finger and BTB domain containing 17 [Source:MGI Symbol;Acc:MGI:107410]69850.2800.0250No
34CebpbCCAAT/enhancer binding protein (C/EBP), beta [Source:MGI Symbol;Acc:MGI:88373]70130.2770.0271No
35Ssr1signal sequence receptor, alpha [Source:MGI Symbol;Acc:MGI:105082]76020.2370.0108No
36Igfbp1insulin-like growth factor binding protein 1 [Source:MGI Symbol;Acc:MGI:96436]83890.226-0.0120No
37Nop14NOP14 nucleolar protein [Source:MGI Symbol;Acc:MGI:1922666]89170.223-0.0266No
38Exosc1exosome component 1 [Source:MGI Symbol;Acc:MGI:1913833]91210.201-0.0309No
39Sec31aSec31 homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916412]96410.150-0.0460No
40Rrp9ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:MGI Symbol;Acc:MGI:2384313]97620.135-0.0484No
41Atf6activating transcription factor 6 [Source:MGI Symbol;Acc:MGI:1926157]97950.131-0.0480No
42Wipi1WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864]100410.113-0.0547No
43Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [Source:MGI Symbol;Acc:MGI:109484]103050.092-0.0621No
44Pdia6protein disulfide isomerase associated 6 [Source:MGI Symbol;Acc:MGI:1919103]105690.065-0.0699No
45Tspyl2TSPY-like 2 [Source:MGI Symbol;Acc:MGI:106244]110050.014-0.0837No
46Arxes2adipocyte-related X-chromosome expressed sequence 2 [Source:MGI Symbol;Acc:MGI:1924226]207550.000-0.3969No
47Spcs1signal peptidase complex subunit 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916269]21142-0.029-0.4090No
48Shc1src homology 2 domain-containing transforming protein C1 [Source:MGI Symbol;Acc:MGI:98296]21257-0.043-0.4122No
49Cks1bCDC28 protein kinase 1b [Source:MGI Symbol;Acc:MGI:1889208]21282-0.046-0.4124No
50Eif4eeukaryotic translation initiation factor 4E [Source:MGI Symbol;Acc:MGI:95305]21377-0.055-0.4149No
51Wfs1wolframin ER transmembrane glycoprotein [Source:MGI Symbol;Acc:MGI:1328355]21453-0.064-0.4166No
52Slc30a5solute carrier family 30 (zinc transporter), member 5 [Source:MGI Symbol;Acc:MGI:1916298]21466-0.066-0.4163No
53Dnajb9DnaJ heat shock protein family (Hsp40) member B9 [Source:MGI Symbol;Acc:MGI:1351618]21693-0.087-0.4226No
54Eif4a2eukaryotic translation initiation factor 4A2 [Source:MGI Symbol;Acc:MGI:106906]21723-0.091-0.4225No
55Edem1ER degradation enhancer, mannosidase alpha-like 1 [Source:MGI Symbol;Acc:MGI:2180139]21899-0.108-0.4270No
56Tubb2atubulin, beta 2A class IIA [Source:MGI Symbol;Acc:MGI:107861]22871-0.174-0.4563No
57Skic3SKI3 subunit of superkiller complex [Source:MGI Symbol;Acc:MGI:2679923]22931-0.182-0.4563No
58Nop56NOP56 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1914384]23049-0.197-0.4579No
59Ddx10DEAD box helicase 10 [Source:MGI Symbol;Acc:MGI:1924841]23092-0.202-0.4571No
60Lsm1LSM1 homolog, mRNA degradation associated [Source:MGI Symbol;Acc:MGI:1914457]23310-0.227-0.4616No
61Exoc2exocyst complex component 2 [Source:MGI Symbol;Acc:MGI:1913732]23420-0.239-0.4625No
62Hspa9heat shock protein 9 [Source:MGI Symbol;Acc:MGI:96245]23979-0.284-0.4774No
63Fkbp14FK506 binding protein 14 [Source:MGI Symbol;Acc:MGI:2387639]24249-0.314-0.4826No
64Srprbsignal recognition particle receptor, B subunit [Source:MGI Symbol;Acc:MGI:102964]24351-0.326-0.4824No
65Eef2eukaryotic translation elongation factor 2 [Source:MGI Symbol;Acc:MGI:95288]24354-0.327-0.4789No
66Srprsignal recognition particle receptor ('docking protein') [Source:MGI Symbol;Acc:MGI:1914648]26440-0.501-0.5405No
67Eif2s1eukaryotic translation initiation factor 2, subunit 1 alpha [Source:MGI Symbol;Acc:MGI:95299]26817-0.558-0.5466Yes
68Gosr2golgi SNAP receptor complex member 2 [Source:MGI Symbol;Acc:MGI:1927204]26888-0.574-0.5426Yes
69Pop4processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913411]26908-0.578-0.5370Yes
70Nfybnuclear transcription factor-Y beta [Source:MGI Symbol;Acc:MGI:97317]26972-0.588-0.5327Yes
71Cnot6CCR4-NOT transcription complex, subunit 6 [Source:MGI Symbol;Acc:MGI:2144529]27046-0.600-0.5286Yes
72Sec11aSEC11 homolog A, signal peptidase complex subunit [Source:MGI Symbol;Acc:MGI:1929464]27240-0.636-0.5279Yes
73Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 [Source:MGI Symbol;Acc:MGI:2145953]27356-0.646-0.5247Yes
74Pdia5protein disulfide isomerase associated 5 [Source:MGI Symbol;Acc:MGI:1919849]27366-0.647-0.5180Yes
75Eif4a1eukaryotic translation initiation factor 4A1 [Source:MGI Symbol;Acc:MGI:95303]27437-0.656-0.5132Yes
76Banf1BAF nuclear assembly factor 1 [Source:MGI Symbol;Acc:MGI:1346330]27459-0.661-0.5067Yes
77Exosc4exosome component 4 [Source:MGI Symbol;Acc:MGI:1923576]27521-0.674-0.5014Yes
78Exosc9exosome component 9 [Source:MGI Symbol;Acc:MGI:1355319]27948-0.759-0.5069Yes
79Yif1aYip1 interacting factor homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915340]27978-0.767-0.4996Yes
80Lsm4LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:MGI Symbol;Acc:MGI:1354692]28005-0.773-0.4921Yes
81Eif4a3eukaryotic translation initiation factor 4A3 [Source:MGI Symbol;Acc:MGI:1923731]28518-0.893-0.4989Yes
82Nabp1nucleic acid binding protein 1 [Source:MGI Symbol;Acc:MGI:1923258]28604-0.916-0.4918Yes
83Exosc5exosome component 5 [Source:MGI Symbol;Acc:MGI:107889]28773-0.962-0.4868Yes
84Parnpoly(A)-specific ribonuclease (deadenylation nuclease) [Source:MGI Symbol;Acc:MGI:1921358]28847-0.982-0.4786Yes
85Nhp2NHP2 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1098547]28979-1.025-0.4717Yes
86Xbp1X-box binding protein 1 [Source:MGI Symbol;Acc:MGI:98970]29175-1.082-0.4664Yes
87Serp1stress-associated endoplasmic reticulum protein 1 [Source:MGI Symbol;Acc:MGI:92638]29209-1.093-0.4556Yes
88Gemin4gem nuclear organelle associated protein 4 [Source:MGI Symbol;Acc:MGI:2449313]29347-1.138-0.4478Yes
89Xpotexportin, tRNA (nuclear export receptor for tRNAs) [Source:MGI Symbol;Acc:MGI:1920442]29550-1.221-0.4411Yes
90Iarsisoleucine-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2145219]29610-1.244-0.4296Yes
91Imp3IMP3, U3 small nucleolar ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1916119]29764-1.313-0.4204Yes
92Rps14ribosomal protein S14 [Source:MGI Symbol;Acc:MGI:98107]29853-1.348-0.4087Yes
93Herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [Source:MGI Symbol;Acc:MGI:1927406]30014-1.440-0.3983Yes
94Tarsthreonyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:106314]30049-1.458-0.3837Yes
95Npm1nucleophosmin 1 [Source:MGI Symbol;Acc:MGI:106184]30246-1.586-0.3729Yes
96Atf3activating transcription factor 3 [Source:MGI Symbol;Acc:MGI:109384]30287-1.613-0.3568Yes
97CebpgCCAAT/enhancer binding protein (C/EBP), gamma [Source:MGI Symbol;Acc:MGI:104982]30322-1.638-0.3402Yes
98Slc7a5solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 [Source:MGI Symbol;Acc:MGI:1298205]30378-1.684-0.3239Yes
99Psat1phosphoserine aminotransferase 1 [Source:MGI Symbol;Acc:MGI:2183441]30499-1.799-0.3083Yes
100Ero1aendoplasmic reticulum oxidoreductase 1 alpha [Source:MGI Symbol;Acc:MGI:1354385]30622-1.938-0.2914Yes
101Ern1endoplasmic reticulum (ER) to nucleus signalling 1 [Source:MGI Symbol;Acc:MGI:1930134]30723-2.062-0.2724Yes
102Eif4ebp1eukaryotic translation initiation factor 4E binding protein 1 [Source:MGI Symbol;Acc:MGI:103267]30756-2.111-0.2507Yes
103Mthfd2methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase [Source:MGI Symbol;Acc:MGI:1338850]30816-2.190-0.2290Yes
104Aldh18a1aldehyde dehydrogenase 18 family, member A1 [Source:MGI Symbol;Acc:MGI:1888908]30827-2.209-0.2055Yes
105Atf4activating transcription factor 4 [Source:MGI Symbol;Acc:MGI:88096]30833-2.219-0.1817Yes
106Stc2stanniocalcin 2 [Source:MGI Symbol;Acc:MGI:1316731]30853-2.249-0.1581Yes
107Vegfavascular endothelial growth factor A [Source:MGI Symbol;Acc:MGI:103178]31008-2.617-0.1349Yes
108Slc1a4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 [Source:MGI Symbol;Acc:MGI:2135601]31057-2.768-0.1066Yes
109Asnsasparagine synthetase [Source:MGI Symbol;Acc:MGI:1350929]31131-3.123-0.0753Yes
110Chac1ChaC, cation transport regulator 1 [Source:MGI Symbol;Acc:MGI:1916315]31174-3.613-0.0377Yes
111Ddit4DNA-damage-inducible transcript 4 [Source:MGI Symbol;Acc:MGI:1921997]31176-3.6880.0020Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_UNFOLDED_PROTEIN_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_UNFOLDED_PROTEIN_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_UNFOLDED_PROTEIN_RESPONSE