Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_UV_RESPONSE_DN
Enrichment Score (ES)0.43752864
Normalized Enrichment Score (NES)1.4962618
Nominal p-value0.0
FDR q-value0.021909256
FWER p-Value0.085
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_UV_RESPONSE_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Kalrnkalirin, RhoGEF kinase [Source:MGI Symbol;Acc:MGI:2685385]562.5410.0196Yes
2Dusp1dual specificity phosphatase 1 [Source:MGI Symbol;Acc:MGI:105120]752.4330.0396Yes
3Atp2b4ATPase, Ca++ transporting, plasma membrane 4 [Source:MGI Symbol;Acc:MGI:88111]1122.2490.0574Yes
4Irs1insulin receptor substrate 1 [Source:MGI Symbol;Acc:MGI:99454]1352.1500.0748Yes
5Plpp3phospholipid phosphatase 3 [Source:MGI Symbol;Acc:MGI:1915166]1392.1420.0928Yes
6Atxn1ataxin 1 [Source:MGI Symbol;Acc:MGI:104783]1522.0920.1101Yes
7Ddah1dimethylarginine dimethylaminohydrolase 1 [Source:MGI Symbol;Acc:MGI:1916469]2181.9320.1243Yes
8Grk5G protein-coupled receptor kinase 5 [Source:MGI Symbol;Acc:MGI:109161]2631.8380.1384Yes
9Igf1rinsulin-like growth factor I receptor [Source:MGI Symbol;Acc:MGI:96433]3231.7410.1512Yes
10Apbb2amyloid beta (A4) precursor protein-binding, family B, member 2 [Source:MGI Symbol;Acc:MGI:108405]3811.6740.1635Yes
11Ptprmprotein tyrosine phosphatase, receptor type, M [Source:MGI Symbol;Acc:MGI:102694]3841.6700.1775Yes
12Rxraretinoid X receptor alpha [Source:MGI Symbol;Acc:MGI:98214]3911.6620.1913Yes
13Smad7SMAD family member 7 [Source:MGI Symbol;Acc:MGI:1100518]4291.6200.2038Yes
14Sipa1l1signal-induced proliferation-associated 1 like 1 [Source:MGI Symbol;Acc:MGI:2443679]4341.6120.2173Yes
15Sdc2syndecan 2 [Source:MGI Symbol;Acc:MGI:1349165]4551.5850.2300Yes
16Vav2vav 2 oncogene [Source:MGI Symbol;Acc:MGI:102718]4841.5500.2422Yes
17Rnd3Rho family GTPase 3 [Source:MGI Symbol;Acc:MGI:1921444]5781.4750.2516Yes
18Celf2CUGBP, Elav-like family member 2 [Source:MGI Symbol;Acc:MGI:1338822]5801.4730.2640Yes
19Atrnattractin [Source:MGI Symbol;Acc:MGI:1341628]9041.2710.2644Yes
20Phf3PHD finger protein 3 [Source:MGI Symbol;Acc:MGI:2446126]10171.2150.2710Yes
21Notch2notch 2 [Source:MGI Symbol;Acc:MGI:97364]10981.1780.2784Yes
22Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [Source:MGI Symbol;Acc:MGI:1306784]11661.1560.2860Yes
23Tent4aterminal nucleotidyltransferase 4A [Source:MGI Symbol;Acc:MGI:2682295]11841.1500.2952Yes
24Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 1 [Source:MGI Symbol;Acc:MGI:97608]12011.1420.3043Yes
25Ythdc1YTH domain containing 1 [Source:MGI Symbol;Acc:MGI:2443713]12441.1240.3124Yes
26Lamc1laminin, gamma 1 [Source:MGI Symbol;Acc:MGI:99914]12461.1230.3219Yes
27Zmiz1zinc finger, MIZ-type containing 1 [Source:MGI Symbol;Acc:MGI:3040693]12551.1200.3311Yes
28Fzd2frizzled class receptor 2 [Source:MGI Symbol;Acc:MGI:1888513]13011.1040.3389Yes
29Schip1schwannomin interacting protein 1 [Source:MGI Symbol;Acc:MGI:1353557]13411.0900.3469Yes
30Aggf1angiogenic factor with G patch and FHA domains 1 [Source:MGI Symbol;Acc:MGI:1913799]13991.0680.3541Yes
31Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a [Source:MGI Symbol;Acc:MGI:1330299]14501.0510.3613Yes
32Adgrl2adhesion G protein-coupled receptor L2 [Source:MGI Symbol;Acc:MGI:2139714]15121.0300.3680Yes
33Ptpn21protein tyrosine phosphatase, non-receptor type 21 [Source:MGI Symbol;Acc:MGI:1344406]15891.0080.3741Yes
34Cdc42bpaCDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]15931.0070.3825Yes
35Bmpr1abone morphogenetic protein receptor, type 1A [Source:MGI Symbol;Acc:MGI:1338938]16700.9860.3884Yes
36Dlc1deleted in liver cancer 1 [Source:MGI Symbol;Acc:MGI:1354949]17140.9760.3952Yes
37Ccn1cellular communication network factor 1 [Source:MGI Symbol;Acc:MGI:88613]18950.9330.3973Yes
38Ltbp1latent transforming growth factor beta binding protein 1 [Source:MGI Symbol;Acc:MGI:109151]19460.9180.4034Yes
39Ptenphosphatase and tensin homolog [Source:MGI Symbol;Acc:MGI:109583]19770.9120.4102Yes
40Prdm2PR domain containing 2, with ZNF domain [Source:MGI Symbol;Acc:MGI:107628]20920.8880.4140Yes
41Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [Source:MGI Symbol;Acc:MGI:97312]21110.8840.4209Yes
42Cav1caveolin 1, caveolae protein [Source:MGI Symbol;Acc:MGI:102709]22340.8600.4242Yes
43Pias3protein inhibitor of activated STAT 3 [Source:MGI Symbol;Acc:MGI:1913126]22560.8550.4308Yes
44Pik3r3phosphoinositide-3-kinase regulatory subunit 3 [Source:MGI Symbol;Acc:MGI:109277]23560.8370.4346Yes
45Nr3c1nuclear receptor subfamily 3, group C, member 1 [Source:MGI Symbol;Acc:MGI:95824]28610.7380.4247Yes
46Rgs4regulator of G-protein signaling 4 [Source:MGI Symbol;Acc:MGI:108409]30710.6990.4238Yes
47Col1a2collagen, type I, alpha 2 [Source:MGI Symbol;Acc:MGI:88468]31300.6900.4278Yes
48Nfibnuclear factor I/B [Source:MGI Symbol;Acc:MGI:103188]31710.6840.4323Yes
49Atp2c1ATPase, Ca++-sequestering [Source:MGI Symbol;Acc:MGI:1889008]31880.6820.4375Yes
50Dlg1discs large MAGUK scaffold protein 1 [Source:MGI Symbol;Acc:MGI:107231]36560.6080.4276No
51NipblNIPBL cohesin loading factor [Source:MGI Symbol;Acc:MGI:1913976]37780.5880.4287No
52AtrxATRX, chromatin remodeler [Source:MGI Symbol;Acc:MGI:103067]38800.5740.4303No
53Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit [Source:MGI Symbol;Acc:MGI:109482]39000.5710.4345No
54Id1inhibitor of DNA binding 1, HLH protein [Source:MGI Symbol;Acc:MGI:96396]42190.5290.4287No
55Fhl2four and a half LIM domains 2 [Source:MGI Symbol;Acc:MGI:1338762]42220.5280.4331No
56Cdk13cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]44810.5190.4292No
57Cap2CAP, adenylate cyclase-associated protein, 2 (yeast) [Source:MGI Symbol;Acc:MGI:1914502]46870.4960.4268No
58Ldlrlow density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:96765]47200.4900.4299No
59F3coagulation factor III [Source:MGI Symbol;Acc:MGI:88381]50280.4510.4239No
60RbpmsRNA binding protein gene with multiple splicing [Source:MGI Symbol;Acc:MGI:1334446]50930.4450.4255No
61Plcb4phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI:107464]55680.3970.4137No
62Nrp1neuropilin 1 [Source:MGI Symbol;Acc:MGI:106206]56430.3910.4146No
63Ptgfrprostaglandin F receptor [Source:MGI Symbol;Acc:MGI:97796]59600.3770.4076No
64Col5a2collagen, type V, alpha 2 [Source:MGI Symbol;Acc:MGI:88458]59760.3770.4103No
65Col11a1collagen, type XI, alpha 1 [Source:MGI Symbol;Acc:MGI:88446]62350.3590.4050No
66Mapk14mitogen-activated protein kinase 14 [Source:MGI Symbol;Acc:MGI:1346865]62610.3560.4072No
67Nek7NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645]63290.3480.4080No
68Scaf8SR-related CTD-associated factor 8 [Source:MGI Symbol;Acc:MGI:1925212]63430.3460.4105No
69Mt1metallothionein 1 [Source:MGI Symbol;Acc:MGI:97171]65090.3270.4080No
70Mmp16matrix metallopeptidase 16 [Source:MGI Symbol;Acc:MGI:1276107]65220.3260.4103No
71Acvr2aactivin receptor IIA [Source:MGI Symbol;Acc:MGI:102806]66400.3100.4092No
72Togaram1TOG array regulator of axonemal microtubules 1 [Source:MGI Symbol;Acc:MGI:2684313]66640.3080.4110No
73Atp2b1ATPase, Ca++ transporting, plasma membrane 1 [Source:MGI Symbol;Acc:MGI:104653]67900.3000.4096No
74Pdgfrbplatelet derived growth factor receptor, beta polypeptide [Source:MGI Symbol;Acc:MGI:97531]71420.2760.4006No
75Nr1d2nuclear receptor subfamily 1, group D, member 2 [Source:MGI Symbol;Acc:MGI:2449205]75390.2410.3899No
76Prkar2bprotein kinase, cAMP dependent regulatory, type II beta [Source:MGI Symbol;Acc:MGI:97760]76110.2360.3896No
77Prkceprotein kinase C, epsilon [Source:MGI Symbol;Acc:MGI:97599]76400.2330.3907No
78KitKIT proto-oncogene receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:96677]79100.2260.3839No
79MgmtO-6-methylguanine-DNA methyltransferase [Source:MGI Symbol;Acc:MGI:96977]83460.2260.3718No
80Cdoncell adhesion molecule-related/down-regulated by oncogenes [Source:MGI Symbol;Acc:MGI:1926387]90860.2050.3498No
81Pik3cdphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [Source:MGI Symbol;Acc:MGI:1098211]94020.1770.3412No
82Rasa2RAS p21 protein activator 2 [Source:MGI Symbol;Acc:MGI:2149960]95230.1630.3387No
83Runx1runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852]95680.1580.3386No
84Inpp4binositol polyphosphate-4-phosphatase, type II [Source:MGI Symbol;Acc:MGI:2158925]97520.1360.3339No
85Magi2membrane associated guanylate kinase, WW and PDZ domain containing 2 [Source:MGI Symbol;Acc:MGI:1354953]98390.1260.3322No
86Gcnt1glucosaminyl (N-acetyl) transferase 1, core 2 [Source:MGI Symbol;Acc:MGI:95676]98470.1260.3330No
87Tgfbr3transforming growth factor, beta receptor III [Source:MGI Symbol;Acc:MGI:104637]99560.1230.3306No
88Srisorcin [Source:MGI Symbol;Acc:MGI:98419]100060.1160.3300No
89Metmet proto-oncogene [Source:MGI Symbol;Acc:MGI:96969]100900.1070.3282No
90Map2k5mitogen-activated protein kinase kinase 5 [Source:MGI Symbol;Acc:MGI:1346345]102160.0990.3250No
91Smad3SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674]102200.0990.3258No
92Prkcaprotein kinase C, alpha [Source:MGI Symbol;Acc:MGI:97595]102940.0930.3242No
93Mycmyelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]105190.0700.3176No
94Bdnfbrain derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:88145]106090.0620.3153No
95Mgllmonoglyceride lipase [Source:MGI Symbol;Acc:MGI:1346042]116600.0000.2815No
96Fbln5fibulin 5 [Source:MGI Symbol;Acc:MGI:1346091]120300.0000.2696No
97Amphamphiphysin [Source:MGI Symbol;Acc:MGI:103574]156320.0000.1538No
98Anxa2annexin A2 [Source:MGI Symbol;Acc:MGI:88246]21033-0.014-0.0197No
99Lpar1lysophosphatidic acid receptor 1 [Source:MGI Symbol;Acc:MGI:108429]21146-0.030-0.0231No
100Has2hyaluronan synthase 2 [Source:MGI Symbol;Acc:MGI:107821]21411-0.059-0.0311No
101Adora2badenosine A2b receptor [Source:MGI Symbol;Acc:MGI:99403]21798-0.097-0.0427No
102Dab2disabled 2, mitogen-responsive phosphoprotein [Source:MGI Symbol;Acc:MGI:109175]21811-0.098-0.0422No
103Tgfbr2transforming growth factor, beta receptor II [Source:MGI Symbol;Acc:MGI:98729]21859-0.104-0.0429No
104Abcc1ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]22243-0.145-0.0540No
105Pex14peroxisomal biogenesis factor 14 [Source:MGI Symbol;Acc:MGI:1927868]22803-0.170-0.0705No
106Mta1metastasis associated 1 [Source:MGI Symbol;Acc:MGI:2150037]22900-0.178-0.0721No
107Tjp1tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759]22991-0.190-0.0734No
108Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [Source:MGI Symbol;Acc:MGI:99923]23351-0.231-0.0830No
109Akt3thymoma viral proto-oncogene 3 [Source:MGI Symbol;Acc:MGI:1345147]23627-0.254-0.0897No
110Scn8asodium channel, voltage-gated, type VIII, alpha [Source:MGI Symbol;Acc:MGI:103169]23879-0.277-0.0954No
111Sfmbt1Scm-like with four mbt domains 1 [Source:MGI Symbol;Acc:MGI:1859609]24275-0.318-0.1054No
112Pdlim5PDZ and LIM domain 5 [Source:MGI Symbol;Acc:MGI:1927489]24353-0.327-0.1051No
113Col3a1collagen, type III, alpha 1 [Source:MGI Symbol;Acc:MGI:88453]25025-0.357-0.1237No
114Cdkn1bcyclin-dependent kinase inhibitor 1B [Source:MGI Symbol;Acc:MGI:104565]25452-0.399-0.1340No
115Map1bmicrotubule-associated protein 1B [Source:MGI Symbol;Acc:MGI:1306778]25651-0.412-0.1369No
116Anxa4annexin A4 [Source:MGI Symbol;Acc:MGI:88030]25900-0.434-0.1412No
117Synj2synaptojanin 2 [Source:MGI Symbol;Acc:MGI:1201671]26369-0.492-0.1522No
118Erbb2erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410]26441-0.501-0.1502No
119Mrps31mitochondrial ribosomal protein S31 [Source:MGI Symbol;Acc:MGI:1913153]27112-0.609-0.1666No
120FynFyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602]27162-0.619-0.1630No
121Itgb3integrin beta 3 [Source:MGI Symbol;Acc:MGI:96612]27515-0.673-0.1686No
122Spopspeckle-type BTB/POZ protein [Source:MGI Symbol;Acc:MGI:1343085]27530-0.677-0.1633No
123Ppargperoxisome proliferator activated receptor gamma [Source:MGI Symbol;Acc:MGI:97747]27587-0.691-0.1593No
124Wdr37WD repeat domain 37 [Source:MGI Symbol;Acc:MGI:1920393]27730-0.721-0.1578No
125Bhlhe40basic helix-loop-helix family, member e40 [Source:MGI Symbol;Acc:MGI:1097714]27788-0.731-0.1535No
126DbpD site albumin promoter binding protein [Source:MGI Symbol;Acc:MGI:94866]27894-0.747-0.1505No
127Miosmeiosis regulator for oocyte development [Source:MGI Symbol;Acc:MGI:2182066]27936-0.755-0.1455No
128Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [Source:MGI Symbol;Acc:MGI:88117]27983-0.768-0.1405No
129Syne1spectrin repeat containing, nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152]28669-0.935-0.1546No
130Tfpitissue factor pathway inhibitor [Source:MGI Symbol;Acc:MGI:1095418]28721-0.949-0.1482No
131Bckdhbbranched chain ketoacid dehydrogenase E1, beta polypeptide [Source:MGI Symbol;Acc:MGI:88137]28761-0.958-0.1414No
132Col1a1collagen, type I, alpha 1 [Source:MGI Symbol;Acc:MGI:88467]28889-0.992-0.1371No
133Ica1islet cell autoantigen 1 [Source:MGI Symbol;Acc:MGI:96391]29261-1.108-0.1397No
134Insig1insulin induced gene 1 [Source:MGI Symbol;Acc:MGI:1916289]29472-1.190-0.1364No
135Efemp1epidermal growth factor-containing fibulin-like extracellular matrix protein 1 [Source:MGI Symbol;Acc:MGI:1339998]29629-1.254-0.1309No
136Arhgef9CDC42 guanine nucleotide exchange factor (GEF) 9 [Source:MGI Symbol;Acc:MGI:2442233]29690-1.278-0.1220No
137Igfbp5insulin-like growth factor binding protein 5 [Source:MGI Symbol;Acc:MGI:96440]29970-1.413-0.1191No
138Add3adducin 3 (gamma) [Source:MGI Symbol;Acc:MGI:1351615]29978-1.419-0.1073No
139Dmac2ldistal membrane arm assembly complex 2 like [Source:MGI Symbol;Acc:MGI:1915305]30710-2.049-0.1135No
140Snai2snail family zinc finger 2 [Source:MGI Symbol;Acc:MGI:1096393]30929-2.409-0.1002No
141Slc22a18solute carrier family 22 (organic cation transporter), member 18 [Source:MGI Symbol;Acc:MGI:1336884]31042-2.740-0.0807No
142Pmp22peripheral myelin protein 22 [Source:MGI Symbol;Acc:MGI:97631]31061-2.787-0.0578No
143Gja1gap junction protein, alpha 1 [Source:MGI Symbol;Acc:MGI:95713]31172-3.598-0.0309No
144Vldlrvery low density lipoprotein receptor [Source:MGI Symbol;Acc:MGI:98935]31199-3.9130.0013No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_UV_RESPONSE_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_UV_RESPONSE_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_UV_RESPONSE_DN