Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_UV_RESPONSE_UP
Enrichment Score (ES)0.29641765
Normalized Enrichment Score (NES)1.0162523
Nominal p-value0.37551022
FDR q-value0.46297404
FWER p-Value0.996
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_UV_RESPONSE_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 8 [Source:MGI Symbol;Acc:MGI:2147834]942.3220.0184Yes
2Ccne1cyclin E1 [Source:MGI Symbol;Acc:MGI:88316]1542.0870.0358Yes
3FosbFBJ osteosarcoma oncogene B [Source:MGI Symbol;Acc:MGI:95575]1872.0120.0533Yes
4Furinfurin (paired basic amino acid cleaving enzyme) [Source:MGI Symbol;Acc:MGI:97513]2381.8840.0691Yes
5Bcl2l11BCL2-like 11 (apoptosis facilitator) [Source:MGI Symbol;Acc:MGI:1197519]3111.7480.0829Yes
6Prkcdprotein kinase C, delta [Source:MGI Symbol;Acc:MGI:97598]3541.6970.0972Yes
7Mmp14matrix metallopeptidase 14 (membrane-inserted) [Source:MGI Symbol;Acc:MGI:101900]3561.6940.1128Yes
8Nfkbianuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [Source:MGI Symbol;Acc:MGI:104741]4901.5410.1228Yes
9Ccnd3cyclin D3 [Source:MGI Symbol;Acc:MGI:88315]8931.2740.1216Yes
10Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88588]10391.2030.1280Yes
11Ephx1epoxide hydrolase 1, microsomal [Source:MGI Symbol;Acc:MGI:95405]10541.1940.1386Yes
12Aqp3aquaporin 3 [Source:MGI Symbol;Acc:MGI:1333777]10591.1920.1495Yes
13Tuba4atubulin, alpha 4A [Source:MGI Symbol;Acc:MGI:1095410]10931.1790.1593Yes
14Hyal2hyaluronoglucosaminidase 2 [Source:MGI Symbol;Acc:MGI:1196334]11041.1750.1698Yes
15Retret proto-oncogene [Source:MGI Symbol;Acc:MGI:97902]12001.1430.1773Yes
16Cckcholecystokinin [Source:MGI Symbol;Acc:MGI:88297]12341.1300.1867Yes
17Ago2argonaute RISC catalytic subunit 2 [Source:MGI Symbol;Acc:MGI:2446632]13611.0830.1926Yes
18Ppp1r2protein phosphatase 1, regulatory inhibitor subunit 2 [Source:MGI Symbol;Acc:MGI:1914099]13631.0830.2026Yes
19Rhobras homolog family member B [Source:MGI Symbol;Acc:MGI:107949]16141.0010.2038Yes
20Glsglutaminase [Source:MGI Symbol;Acc:MGI:95752]16150.9990.2130Yes
21Ppatphosphoribosyl pyrophosphate amidotransferase [Source:MGI Symbol;Acc:MGI:2387203]16190.9980.2221Yes
22Tfrctransferrin receptor [Source:MGI Symbol;Acc:MGI:98822]16280.9960.2311Yes
23Tgfbrap1transforming growth factor, beta receptor associated protein 1 [Source:MGI Symbol;Acc:MGI:2447427]21370.8790.2228Yes
24Dnaja1DnaJ heat shock protein family (Hsp40) member A1 [Source:MGI Symbol;Acc:MGI:1270129]22670.8540.2266Yes
25Cltbclathrin, light polypeptide (Lcb) [Source:MGI Symbol;Acc:MGI:1921575]23310.8420.2323Yes
26Hnrnpuheterogeneous nuclear ribonucleoprotein U [Source:MGI Symbol;Acc:MGI:1858195]23470.8380.2396Yes
27Il6stinterleukin 6 signal transducer [Source:MGI Symbol;Acc:MGI:96560]23510.8370.2472Yes
28Nup58nucleoporin 58 [Source:MGI Symbol;Acc:MGI:1919094]24660.8130.2511Yes
29Tyro3TYRO3 protein tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:104294]26800.7690.2513Yes
30Il6interleukin 6 [Source:MGI Symbol;Acc:MGI:96559]26940.7680.2580Yes
31Cyb5bcytochrome b5 type B [Source:MGI Symbol;Acc:MGI:1913677]27770.7540.2623Yes
32Ctslcathepsin L [Source:MGI Symbol;Acc:MGI:88564]29000.7310.2651Yes
33Prpf3pre-mRNA processing factor 3 [Source:MGI Symbol;Acc:MGI:1918017]29130.7290.2715Yes
34Onecut1one cut domain, family member 1 [Source:MGI Symbol;Acc:MGI:1196423]31450.6880.2704Yes
35Bak1BCL2-antagonist/killer 1 [Source:MGI Symbol;Acc:MGI:1097161]32640.6700.2728Yes
36BidBH3 interacting domain death agonist [Source:MGI Symbol;Acc:MGI:108093]32680.6700.2788Yes
37Amd1S-adenosylmethionine decarboxylase 1 [Source:MGI Symbol;Acc:MGI:88004]32700.6700.2850Yes
38Nkx2-5NK2 homeobox 5 [Source:MGI Symbol;Acc:MGI:97350]33410.6620.2889Yes
39Eno2enolase 2, gamma neuronal [Source:MGI Symbol;Acc:MGI:95394]33500.6620.2947Yes
40Btg1BTG anti-proliferation factor 1 [Source:MGI Symbol;Acc:MGI:88215]34810.6390.2964Yes
41Ddx21DExD box helicase 21 [Source:MGI Symbol;Acc:MGI:1860494]38280.5800.2906No
42Prkacaprotein kinase, cAMP dependent, catalytic, alpha [Source:MGI Symbol;Acc:MGI:97592]38710.5750.2946No
43Ppt1palmitoyl-protein thioesterase 1 [Source:MGI Symbol;Acc:MGI:1298204]44610.5210.2805No
44Cdk2cyclin-dependent kinase 2 [Source:MGI Symbol;Acc:MGI:104772]44750.5190.2848No
45H2axH2A.X variant histone [Source:MGI Symbol;Acc:MGI:102688]45810.5080.2862No
46Nptxrneuronal pentraxin receptor [Source:MGI Symbol;Acc:MGI:1920590]45990.5060.2903No
47Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:MGI Symbol;Acc:MGI:1913418]47140.4910.2911No
48Fen1flap structure specific endonuclease 1 [Source:MGI Symbol;Acc:MGI:102779]48350.4760.2917No
49Dnajb1DnaJ heat shock protein family (Hsp40) member B1 [Source:MGI Symbol;Acc:MGI:1931874]50500.4500.2889No
50Ppifpeptidylprolyl isomerase F (cyclophilin F) [Source:MGI Symbol;Acc:MGI:2145814]53930.4050.2817No
51Mapk8ip2mitogen-activated protein kinase 8 interacting protein 2 [Source:MGI Symbol;Acc:MGI:1926555]55230.3970.2812No
52Pdap1PDGFA associated protein 1 [Source:MGI Symbol;Acc:MGI:2448536]56230.3930.2816No
53Clcn2chloride channel, voltage-sensitive 2 [Source:MGI Symbol;Acc:MGI:105061]56870.3860.2832No
54Pdlim3PDZ and LIM domain 3 [Source:MGI Symbol;Acc:MGI:1859274]57680.3770.2841No
55Mark2MAP/microtubule affinity regulating kinase 2 [Source:MGI Symbol;Acc:MGI:99638]60690.3770.2779No
56Nr4a1nuclear receptor subfamily 4, group A, member 1 [Source:MGI Symbol;Acc:MGI:1352454]63450.3460.2723No
57Wizwidely-interspaced zinc finger motifs [Source:MGI Symbol;Acc:MGI:1332638]64130.3370.2732No
58Tacr3tachykinin receptor 3 [Source:MGI Symbol;Acc:MGI:892968]64280.3370.2759No
59Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C1 [Source:MGI Symbol;Acc:MGI:1913585]68850.2920.2639No
60Galgalanin and GMAP prepropeptide [Source:MGI Symbol;Acc:MGI:95637]70340.2760.2617No
61Apomapolipoprotein M [Source:MGI Symbol;Acc:MGI:1930124]72970.2650.2557No
62Ntrk3neurotrophic tyrosine kinase, receptor, type 3 [Source:MGI Symbol;Acc:MGI:97385]73340.2640.2570No
63Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 3 [Source:MGI Symbol;Acc:MGI:1098754]74840.2440.2544No
64LynLYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892]89020.2240.2109No
65Junbjun B proto-oncogene [Source:MGI Symbol;Acc:MGI:96647]96910.1440.1869No
66Cdc5lcell division cycle 5-like (S. pombe) [Source:MGI Symbol;Acc:MGI:1918952]97060.1420.1877No
67Cdc34cell division cycle 34 [Source:MGI Symbol;Acc:MGI:102657]97750.1330.1868No
68Creg1cellular repressor of E1A-stimulated genes 1 [Source:MGI Symbol;Acc:MGI:1344382]99780.1200.1814No
69Abcb1aATP-binding cassette, sub-family B (MDR/TAP), member 1A [Source:MGI Symbol;Acc:MGI:97570]99900.1190.1821No
70Cxcl1chemokine (C-X-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:108068]100340.1140.1818No
71Fmo1flavin containing monooxygenase 1 [Source:MGI Symbol;Acc:MGI:1310002]103260.0880.1733No
72Ap2s1adaptor-related protein complex 2, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:2141861]103980.0820.1717No
73Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 2 [Source:MGI Symbol;Acc:MGI:1341722]106960.0520.1627No
74Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked [Source:MGI Symbol;Acc:MGI:1349431]107100.0510.1627No
75Alas1aminolevulinic acid synthase 1 [Source:MGI Symbol;Acc:MGI:87989]108820.0320.1575No
76Klhdc3kelch domain containing 3 [Source:MGI Symbol;Acc:MGI:2651568]109720.0190.1548No
77Igfbp2insulin-like growth factor binding protein 2 [Source:MGI Symbol;Acc:MGI:96437]119700.0000.1227No
78Lhx2LIM homeobox protein 2 [Source:MGI Symbol;Acc:MGI:96785]149520.0000.0268No
79Cdkn1ccyclin-dependent kinase inhibitor 1C (P57) [Source:MGI Symbol;Acc:MGI:104564]169650.000-0.0379No
80Htr75-hydroxytryptamine (serotonin) receptor 7 [Source:MGI Symbol;Acc:MGI:99841]179960.000-0.0710No
81Msx1msh homeobox 1 [Source:MGI Symbol;Acc:MGI:97168]183850.000-0.0835No
82Chrna5cholinergic receptor, nicotinic, alpha polypeptide 5 [Source:MGI Symbol;Acc:MGI:87889]184930.000-0.0870No
83Nptx2neuronal pentraxin 2 [Source:MGI Symbol;Acc:MGI:1858209]190980.000-0.1064No
84Olfm1olfactomedin 1 [Source:MGI Symbol;Acc:MGI:1860437]197470.000-0.1272No
85Grpel1GrpE-like 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1334417]20959-0.001-0.1662No
86Pole3polymerase (DNA directed), epsilon 3 (p17 subunit) [Source:MGI Symbol;Acc:MGI:1933378]21309-0.048-0.1770No
87Cdo1cysteine dioxygenase 1, cytosolic [Source:MGI Symbol;Acc:MGI:105925]21400-0.057-0.1793No
88Icam1intercellular adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:96392]21560-0.076-0.1837No
89Sigmar1sigma non-opioid intracellular receptor 1 [Source:MGI Symbol;Acc:MGI:1195268]21569-0.076-0.1833No
90Ptprdprotein tyrosine phosphatase, receptor type, D [Source:MGI Symbol;Acc:MGI:97812]21597-0.078-0.1834No
91Selenowselenoprotein W [Source:MGI Symbol;Acc:MGI:1100878]21708-0.089-0.1862No
92Sod2superoxide dismutase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:98352]21816-0.099-0.1887No
93Ykt6YKT6 v-SNARE homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1927550]21851-0.103-0.1888No
94Tmbim6transmembrane BAX inhibitor motif containing 6 [Source:MGI Symbol;Acc:MGI:99682]22188-0.139-0.1984No
95Mgat1mannoside acetylglucosaminyltransferase 1 [Source:MGI Symbol;Acc:MGI:96973]22227-0.143-0.1983No
96Plcl1phospholipase C-like 1 [Source:MGI Symbol;Acc:MGI:3036262]22262-0.146-0.1980No
97Aldoaaldolase A, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87994]22747-0.164-0.2121No
98Hspa2heat shock protein 2 [Source:MGI Symbol;Acc:MGI:96243]22925-0.180-0.2161No
99Parp2poly (ADP-ribose) polymerase family, member 2 [Source:MGI Symbol;Acc:MGI:1341112]23107-0.204-0.2200No
100Eif5eukaryotic translation initiation factor 5 [Source:MGI Symbol;Acc:MGI:95309]23262-0.223-0.2229No
101Maoamonoamine oxidase A [Source:MGI Symbol;Acc:MGI:96915]23311-0.227-0.2224No
102Rpn1ribophorin I [Source:MGI Symbol;Acc:MGI:98084]23681-0.256-0.2319No
103Nxf1nuclear RNA export factor 1 [Source:MGI Symbol;Acc:MGI:1858330]24026-0.289-0.2403No
104Slc25a4solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [Source:MGI Symbol;Acc:MGI:1353495]24033-0.290-0.2378No
105Polr2hpolymerase (RNA) II (DNA directed) polypeptide H [Source:MGI Symbol;Acc:MGI:2384309]24207-0.310-0.2405No
106E2f5E2F transcription factor 5 [Source:MGI Symbol;Acc:MGI:105091]24232-0.313-0.2384No
107Btg3BTG anti-proliferation factor 3 [Source:MGI Symbol;Acc:MGI:109532]24242-0.314-0.2358No
108RradRas-related associated with diabetes [Source:MGI Symbol;Acc:MGI:1930943]24264-0.316-0.2335No
109Gghgamma-glutamyl hydrolase [Source:MGI Symbol;Acc:MGI:1329035]24533-0.351-0.2389No
110Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Source:MGI Symbol;Acc:MGI:95628]24765-0.357-0.2431No
111Col2a1collagen, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:88452]25013-0.357-0.2477No
112Gpx3glutathione peroxidase 3 [Source:MGI Symbol;Acc:MGI:105102]25235-0.369-0.2514No
113Gch1GTP cyclohydrolase 1 [Source:MGI Symbol;Acc:MGI:95675]25409-0.392-0.2534No
114Hspa13heat shock protein 70 family, member 13 [Source:MGI Symbol;Acc:MGI:1309463]25431-0.395-0.2504No
115Casp3caspase 3 [Source:MGI Symbol;Acc:MGI:107739]25439-0.397-0.2470No
116Sprsepiapterin reductase [Source:MGI Symbol;Acc:MGI:103078]25794-0.421-0.2545No
117Bsgbasigin [Source:MGI Symbol;Acc:MGI:88208]26037-0.450-0.2581No
118Mrpl23mitochondrial ribosomal protein L23 [Source:MGI Symbol;Acc:MGI:1196612]26075-0.455-0.2551No
119Dgat1diacylglycerol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:1333825]26105-0.459-0.2518No
120Stip1stress-induced phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:109130]26293-0.478-0.2534No
121Hmox1heme oxygenase 1 [Source:MGI Symbol;Acc:MGI:96163]26395-0.495-0.2521No
122Sult1a1sulfotransferase family 1A, phenol-preferring, member 1 [Source:MGI Symbol;Acc:MGI:102896]26415-0.497-0.2481No
123Cyb5r1cytochrome b5 reductase 1 [Source:MGI Symbol;Acc:MGI:1919267]26487-0.507-0.2457No
124Rab27aRAB27A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1861441]26724-0.545-0.2483No
125Cdkn2bcyclin dependent kinase inhibitor 2B [Source:MGI Symbol;Acc:MGI:104737]26912-0.579-0.2489No
126Uroduroporphyrinogen decarboxylase [Source:MGI Symbol;Acc:MGI:98916]27360-0.646-0.2574No
127Bmp2bone morphogenetic protein 2 [Source:MGI Symbol;Acc:MGI:88177]27614-0.697-0.2591No
128Btg2BTG anti-proliferation factor 2 [Source:MGI Symbol;Acc:MGI:108384]27647-0.703-0.2536No
129Rasgrp1RAS guanyl releasing protein 1 [Source:MGI Symbol;Acc:MGI:1314635]27905-0.748-0.2550No
130Dlg4discs large MAGUK scaffold protein 4 [Source:MGI Symbol;Acc:MGI:1277959]27945-0.759-0.2492No
131Rxrbretinoid X receptor beta [Source:MGI Symbol;Acc:MGI:98215]27954-0.760-0.2424No
132Stk25serine/threonine kinase 25 (yeast) [Source:MGI Symbol;Acc:MGI:1891699]28156-0.806-0.2415No
133Rfc4replication factor C (activator 1) 4 [Source:MGI Symbol;Acc:MGI:2146571]28415-0.868-0.2418No
134Acaa1aacetyl-Coenzyme A acyltransferase 1A [Source:MGI Symbol;Acc:MGI:2148491]28500-0.888-0.2363No
135Arrb2arrestin, beta 2 [Source:MGI Symbol;Acc:MGI:99474]28581-0.908-0.2305No
136Tstthiosulfate sulfurtransferase, mitochondrial [Source:MGI Symbol;Acc:MGI:98852]28699-0.943-0.2255No
137Car2carbonic anhydrase 2 [Source:MGI Symbol;Acc:MGI:88269]28961-1.017-0.2245No
138Fkbp4FK506 binding protein 4 [Source:MGI Symbol;Acc:MGI:95543]29113-1.065-0.2196No
139Tchhtrichohyalin [Source:MGI Symbol;Acc:MGI:2177944]29238-1.101-0.2134No
140Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:MGI Symbol;Acc:MGI:98483]29584-1.232-0.2131No
141Chkacholine kinase alpha [Source:MGI Symbol;Acc:MGI:107760]29619-1.248-0.2027No
142Atp6v1fATPase, H+ transporting, lysosomal V1 subunit F [Source:MGI Symbol;Acc:MGI:1913394]29715-1.289-0.1938No
143Polg2polymerase (DNA directed), gamma 2, accessory subunit [Source:MGI Symbol;Acc:MGI:1354947]29805-1.325-0.1845No
144Nat2N-acetyltransferase 2 (arylamine N-acetyltransferase) [Source:MGI Symbol;Acc:MGI:109201]30028-1.444-0.1783No
145Tarsthreonyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:106314]30049-1.458-0.1655No
146Shox2short stature homeobox 2 [Source:MGI Symbol;Acc:MGI:1201673]30162-1.530-0.1549No
147Sqstm1sequestosome 1 [Source:MGI Symbol;Acc:MGI:107931]30170-1.535-0.1410No
148Stard3START domain containing 3 [Source:MGI Symbol;Acc:MGI:1929618]30221-1.568-0.1281No
149Atf3activating transcription factor 3 [Source:MGI Symbol;Acc:MGI:109384]30287-1.613-0.1153No
150CebpgCCAAT/enhancer binding protein (C/EBP), gamma [Source:MGI Symbol;Acc:MGI:104982]30322-1.638-0.1013No
151Irf1interferon regulatory factor 1 [Source:MGI Symbol;Acc:MGI:96590]30512-1.809-0.0907No
152Epcamepithelial cell adhesion molecule [Source:MGI Symbol;Acc:MGI:106653]30633-1.950-0.0765No
153FosFBJ osteosarcoma oncogene [Source:MGI Symbol;Acc:MGI:95574]30804-2.171-0.0620No
154Fgf18fibroblast growth factor 18 [Source:MGI Symbol;Acc:MGI:1277980]30869-2.275-0.0430No
155Cnp2',3'-cyclic nucleotide 3' phosphodiesterase [Source:MGI Symbol;Acc:MGI:88437]31067-2.817-0.0234No
156Asnsasparagine synthetase [Source:MGI Symbol;Acc:MGI:1350929]31131-3.1230.0034No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_UV_RESPONSE_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_UV_RESPONSE_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_UV_RESPONSE_UP