Datasetall_collapsed_to_symbols.all_pheno_new.cls#DBT_versus_SCR
Phenotypeall_pheno_new.cls#DBT_versus_SCR
Upregulated in classDBT
GeneSetHALLMARK_WNT_BETA_CATENIN_SIGNALING
Enrichment Score (ES)0.49774635
Normalized Enrichment Score (NES)1.3897407
Nominal p-value0.050139274
FDR q-value0.04751679
FWER p-Value0.204
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_WNT_BETA_CATENIN_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Fzd8frizzled class receptor 8 [Source:MGI Symbol;Acc:MGI:108460]1852.0180.0705Yes
2Dll1delta like canonical Notch ligand 1 [Source:MGI Symbol;Acc:MGI:104659]4851.5490.1197Yes
3Axin2axin 2 [Source:MGI Symbol;Acc:MGI:1270862]7641.3400.1616Yes
4Ncor2nuclear receptor co-repressor 2 [Source:MGI Symbol;Acc:MGI:1337080]9461.2470.2030Yes
5Ncstnnicastrin [Source:MGI Symbol;Acc:MGI:1891700]13861.0730.2296Yes
6Fzd1frizzled class receptor 1 [Source:MGI Symbol;Acc:MGI:1196625]18330.9470.2512Yes
7Psen2presenilin 2 [Source:MGI Symbol;Acc:MGI:109284]19440.9190.2825Yes
8Csnk1ecasein kinase 1, epsilon [Source:MGI Symbol;Acc:MGI:1351660]19570.9150.3168Yes
9Frat1frequently rearranged in advanced T cell lymphomas [Source:MGI Symbol;Acc:MGI:109450]20500.8970.3479Yes
10Gnai1guanine nucleotide binding protein (G protein), alpha inhibiting 1 [Source:MGI Symbol;Acc:MGI:95771]26760.7690.3570Yes
11NumbNUMB endocytic adaptor protein [Source:MGI Symbol;Acc:MGI:107423]27190.7630.3846Yes
12Wnt1wingless-type MMTV integration site family, member 1 [Source:MGI Symbol;Acc:MGI:98953]28840.7350.4072Yes
13Ctnnb1catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]30730.6980.4276Yes
14Jag1jagged 1 [Source:MGI Symbol;Acc:MGI:1095416]31760.6830.4502Yes
15Dkk1dickkopf WNT signaling pathway inhibitor 1 [Source:MGI Symbol;Acc:MGI:1329040]33660.6600.4692Yes
16Ppardperoxisome proliferator activator receptor delta [Source:MGI Symbol;Acc:MGI:101884]39450.5640.4720Yes
17Skp2S-phase kinase-associated protein 2 [Source:MGI Symbol;Acc:MGI:1351663]40360.5530.4901Yes
18Lef1lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770]48020.4790.4838Yes
19Ptch1patched 1 [Source:MGI Symbol;Acc:MGI:105373]49180.4660.4977Yes
20Nkd1naked cuticle 1 [Source:MGI Symbol;Acc:MGI:2135954]57950.3770.4840No
21Notch1notch 1 [Source:MGI Symbol;Acc:MGI:97363]69590.2830.4574No
22Wnt6wingless-type MMTV integration site family, member 6 [Source:MGI Symbol;Acc:MGI:98960]80060.2260.4324No
23Axin1axin 1 [Source:MGI Symbol;Acc:MGI:1096327]97500.1360.3817No
24Mycmyelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]105190.0700.3598No
25Rbpjrecombination signal binding protein for immunoglobulin kappa J region [Source:MGI Symbol;Acc:MGI:96522]105750.0650.3605No
26Cul1cullin 1 [Source:MGI Symbol;Acc:MGI:1349658]106370.0580.3607No
27Adam17a disintegrin and metallopeptidase domain 17 [Source:MGI Symbol;Acc:MGI:1096335]110680.0030.3470No
28Trp53transformation related protein 53 [Source:MGI Symbol;Acc:MGI:98834]21201-0.0370.0237No
29Hdac5histone deacetylase 5 [Source:MGI Symbol;Acc:MGI:1333784]21384-0.0550.0199No
30Maml1mastermind like transcriptional coactivator 1 [Source:MGI Symbol;Acc:MGI:1890504]22047-0.1220.0033No
31Dvl2dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613]22054-0.1230.0078No
32Kat2aK(lysine) acetyltransferase 2A [Source:MGI Symbol;Acc:MGI:1343101]23399-0.237-0.0263No
33Hdac2histone deacetylase 2 [Source:MGI Symbol;Acc:MGI:1097691]24530-0.351-0.0492No
34Jag2jagged 2 [Source:MGI Symbol;Acc:MGI:1098270]25391-0.390-0.0620No
35Dkk4dickkopf WNT signaling pathway inhibitor 4 [Source:MGI Symbol;Acc:MGI:2385299]25724-0.417-0.0569No
36Wnt5bwingless-type MMTV integration site family, member 5B [Source:MGI Symbol;Acc:MGI:98959]26631-0.528-0.0659No
37Hey1hairy/enhancer-of-split related with YRPW motif 1 [Source:MGI Symbol;Acc:MGI:1341800]26836-0.561-0.0512No
38Hey2hairy/enhancer-of-split related with YRPW motif 2 [Source:MGI Symbol;Acc:MGI:1341884]26871-0.569-0.0307No
39Hdac11histone deacetylase 11 [Source:MGI Symbol;Acc:MGI:2385252]28660-0.932-0.0527No
40Notch4notch 4 [Source:MGI Symbol;Acc:MGI:107471]28871-0.987-0.0220No
41Tcf7transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507]29654-1.2650.0009No
42Ccnd2cyclin D2 [Source:MGI Symbol;Acc:MGI:88314]29772-1.3150.0470No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_WNT_BETA_CATENIN_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_WNT_BETA_CATENIN_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_WNT_BETA_CATENIN_SIGNALING